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Protein

Proteasome subunit alpha

Gene

psmA

Organism
Thermococcus celericrescens
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PsmAUniRule annotation
Gene namesi
Name:psmAUniRule annotation
ORF Names:APY94_06590Imported
OrganismiThermococcus celericrescensImported
Taxonomic identifieri227598 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000053462 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation, ProteasomeUniRule annotationImported

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 32PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili227 – 259Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

CDDicd03756 proteasome_alpha_archeal, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00289_A Proteasome_A_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR019982 Proteasome_asu_arc
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03633 arc_protsome_A, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A100XXY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFVPPQAGY DRAITVFSPD GRLFQVNYAR EAVKRGATAV GVKWKNGVVL
60 70 80 90 100
AVEKRITSKL IEPSSYEKIF QIDDHIAAAP SGIIADARVL VDRARLEAQV
110 120 130 140 150
YRLTYGEPVP LTVLVKKICD LKQAHTQYGG VRPFGAALLM AGVNDKPELY
160 170 180 190 200
ETDPSGAYFE WKAVAIGSGR NTAMAIFEEH YTDDIDMEGA IKLAIMALAK
210 220 230 240 250
TLEEPSADGI EVAYITTDDK RWKKLSREEV EKYLSEILEE VKEEEVEERE
260
EDYSELDQNY
Length:260
Mass (Da):29,100
Last modified:April 13, 2016 - v1
Checksum:i6838FB020E71FC3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LLYW01000022 Genomic DNA Translation: KUH33317.1
RefSeqiWP_058938878.1, NZ_LLYW01000022.1

Genome annotation databases

EnsemblBacteriaiKUH33317; KUH33317; APY94_06590

Similar proteinsi

Entry informationi

Entry nameiA0A100XXY9_9EURY
AccessioniPrimary (citable) accession number: A0A100XXY9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: June 20, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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