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Protein

Hemagglutinin

Gene

HA

Organism
Influenza A virus (A/chicken/Shanghai/S3898/2014(H9))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.SAAS annotation
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutininUniRule annotationSAAS annotation
Biological processClathrin- and caveolin-independent endocytosis of virus by hostSAAS annotation, Clathrin-mediated endocytosis of virus by hostSAAS annotation, Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
HemagglutininSAAS annotation
Gene namesi
Name:HAImported
OrganismiInfluenza A virus (A/chicken/Shanghai/S3898/2014(H9))Imported
Taxonomic identifieri1614120 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeAlphainfluenzavirus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HA1-HA2.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the influenza viruses hemagglutinin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di3.90.209.20, 1 hit
HAMAPiMF_04072 INFV_HEMA, 1 hit
InterProiView protein in InterPro
IPR008980 Capsid_hemagglutn
IPR013828 Hemagglutn_HA1_a/b_dom_sf
IPR000149 Hemagglutn_influenz_A
IPR001364 Hemagglutn_influenz_A/B
PfamiView protein in Pfam
PF00509 Hemagglutinin, 1 hit
PRINTSiPR00330 HEMAGGLUTN1
PR00329 HEMAGGLUTN12
SUPFAMiSSF49818 SSF49818, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0A0X7YRU4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SLITMLLVST VSNADKICIG YQSTNSTETV DTLTENNVPV THAKELLHTE
60 70 80 90 100
HNGMLCATSL GQPLVLDTCT IEGLIYGNPS CDLSLEGREW SYIVERPSAV
110 120 130 140 150
NGLCYPGNVE NLEELRSLFS SARSYQRIQI FPDTIWNVSY DGTSSACSGS
160 170 180 190 200
FYKSMRWLTR KNGDYPIQDA QYTNNQGKNI LFMWGINHPP TDTTQRDLYT
210 220 230 240 250
RTDTTSSVAT EEINRIFKPL IGPRPLVNGL MGRIDYYWSV LKPGHTLPIK
260 270 280 290 300
SDGNLIAPWY GHILSGESHG RVVKTDLKRG RCTVQCQTEK GGLNTALPFQ
310 320 330 340 350
NVSKYAFGRC SKYIGIKSLK LAVGLKNVPS RSSRGLFGAI AGFIEGGWSG
360 370 380 390 400
LVAGWYGFQH SNDQGVGIAA DRDSTQKAID KITSKVNNIV DKMNKQYEII
410 420 430 440
DHEFSEVETR INMINNKIDD QIQDIWAYNA ELLVSLDNQK TLDE
Length:444
Mass (Da):49,418
Last modified:April 13, 2016 - v1
Checksum:i771046310CFC73E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei444Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KP767332 Viral cRNA Translation: AJS17803.1

Entry informationi

Entry nameiA0A0X7YRU4_9INFA
AccessioniPrimary (citable) accession number: A0A0X7YRU4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: May 23, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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