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UniProtKB - A0A0X3Q0G2 (A0A0X3Q0G2_SCHSO)

Entry version 13 (10 Feb 2021)
Sequence version 1 (13 Apr 2016)
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Protein

Mediator of RNA polymerase II transcription subunit 14

Gene

MED14

Organism
Schistocephalus solidus (Tapeworm)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 14UniRule annotation
Alternative name(s):
Mediator complex subunit 14UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED14Imported
ORF Names:TR137402Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchistocephalus solidus (Tapeworm)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri70667 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Cestoda › Eucestoda › Diphyllobothriidea › Diphyllobothriidae › Schistocephalus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex.

UniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 14 family.UniRule annotationARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013947, Mediator_Med14

The PANTHER Classification System

More...PANTHERi		PTHR12809, PTHR12809, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08638, Med14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0X3Q0G2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQLSESRHV VSHPRPGTIP LSTMLEFICQ KTYTDLMRLV DLLPSKTDLE 
        60         70         80         90        100
KKIELAKFFS RTRNLFIRLE ALVKWANSAS KVDKCEKISN FLDEQSFFLL 
       110        120        130        140        150
STANSLSSLL RDNLVEARLP PFAVLHAIDI FVNKTYTRLP KCIKSQIVPP 
       160        170        180        190        200
EAISDREAKM ALLDLNRIIK YRLSMTPLPR QFLDISIKNG CVTFVVPNEF 
       210        220        230        240        250
KVTLTLLSEA LDFPWRILSI SLLVCDPEIS AGSPLLHPLQ TRFLHSQAQS 
       260        270        280        290        300
RILYQHFDKR PPLLHLYEML HSFSVSVQLN VLFEQAQRLL SRRPADTFVI 
       310        320        330        340        350
ESYRPGSQLK VRYWLGLSRC HFQAPLGADG KLKQSAYTVT IHTDPLDPQR 
       360        370        380        390        400
PLCLTHHPKL SVLDANKIGS IVKGDHLSLS NLLSRTVIVR AERILKDLRT 
       410        420        430        440        450
ELLPLSPGPI TLGDVPLCLY VPLLWPCSER ELLYIQVDVA QGLLRTSLAG 
       460        470        480        490        500
LTNPTPTITC FGASVGSGED ALCHLLAQPA VNFRSLLRRL EEALNRPAVR 
       510        520        530        540        550
RIISEGSTEE PMSAAVRSRS LRALANEEAR WQAEMVETLN SLRCLLGQAR 
       560        570        580        590        600
VAAAVSSHRR FCHSVPRNSL PLVVPSDSGG TPARSVLPCL DLLKRMYQGR 
       610        620        630        640        650
AALTFVRLFP CDEYYLVCET VPSGALCVAY RYYLLVCAPI PASTEVFFNA 
       660        670        680        690        700
DGVMVYTKRL WTTSGVAGGG LAHPTFGDTY PGLLLRVTHF LPLGGRQLWP 
       710        720        730        740        750
VGQTFTLPSL RQSVSNAQKQ LLQRRMKRVR LLLDHLPEGA AKRRCLERLD 
       760        770        780        790        800
PHARNLLESS VEVDSNATFP VTATLPVSGL SSLLNTLEED IISTFLTFQL 
       810        820        830        840        850
SLHEISHNGA HYDDQGHILS VDILKIPKGA MPAWVWPGYE ALKRYVQRVL 
       860        870        880        890        900
LVPSGDSPHC IRVWHMNVAF TGLPTAPFGC GGGANGVGEG THLYQTADWP 
       910        920        930        940        950
TQRLSDLNDV VIAIKKEWIS LCSMFTICAP VLSIKGPVCP GVILRQFDAK 
       960        970        980        990       1000
RLTLSYGPGN HFMAELSADS DQGCILSLGT YPVAVPIAED GKCEGNASLL 
      1010       1020       1030       1040       1050
APAVSLRPLE INTGDNPHCL IREHLEYLVN TYKSVRHLAL VLSSTVEFMT 
      1060       1070       1080       1090       1100
ALGSLLRPDF LDMVSMSPSP PARPIGTFAL IALSCYDLLL VYRGVLCMRF 
      1110       1120       1130       1140       1150
KLSLGTSLSA TSGEMTKLPY STVAVDTVQL SDGCRNADVS ARATGDAATA 
      1160       1170       1180       1190       1200
KDYAPLPAFQ QAFLTSLQNA FQMDIEEDSW AGMTVAQLTQ LMSPLKMPSQ 
      1210       1220       1230       1240       1250
PLGAPVARRP SISLLSPLES YFAASLIFHT AYQAALNLHA PILLDPTANS 
      1260       1270       1280       1290       1300
SVQQQQQQQQ PSPSAIYSAG EFSTHWSPSS IVAHLKLTAV RTGVEVSRWR 
      1310       1320       1330       1340       1350
LLLKLSSSAA MQSPEMEARM ADMLARLEEL FETRVCALPL QPSAVLSFFR 
      1360       1370       1380       1390       1400
LLLIPAQVLR ALLCLFDSDL HSGGASQQQQ QQQQQQAPAV RVRVALTSVT 
      1410       1420       1430       1440       1450
SLPDSGVDQA AIVVQPPLLS LQLLVSSLAR RQAVGGTFPP TQSPSFTTGV 
      1460       1470       1480       1490       1500
IPLTFNWTTN RVSITPTTGV GAKCVLAQRL RDARLDEQTN SHCVETNECA 
      1510       1520 
LVQLTRIILQ HPGLGNLATG PTGRA
Length:1,525
Mass (Da):167,680
Last modified:April 13, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3089BBE4EEAD87E0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
GEEE01005967 Transcribed RNA Translation: JAP57258.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GEEE01005967 Transcribed RNA Translation: JAP57258.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR013947, Mediator_Med14
PANTHERiPTHR12809, PTHR12809, 2 hits
PfamiView protein in Pfam
PF08638, Med14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0X3Q0G2_SCHSO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0X3Q0G2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: February 10, 2021
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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