UniProtKB - A0A0X3PZW1 (A0A0X3PZW1_SCHSO)
Protein
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Gene
SDHB
Organism
Schistocephalus solidus (Tapeworm)
Status
Functioni
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotationARBA annotation
Catalytic activityi
: tricarboxylic acid cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotationARBA annotationProteins known to be involved in this subpathway in this organism are:
- Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SSLN_LOCUS10254), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.
GO - Molecular functioni
- 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
- 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- electron transfer activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- tricarboxylic acid cycle Source: UniProtKB-UniPathway
Keywordsi
Molecular function | NeurotoxinARBA annotation, Toxin |
Biological process | Tricarboxylic acid cycleARBA annotation |
Ligand | 2Fe-2SUniRule annotationARBA annotation, 3Fe-4SUniRule annotationARBA annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, UbiquinoneImported |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER01006 |
Names & Taxonomyi
Protein namesi | Recommended name: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation) |
Gene namesi | Name:SDHBImported ORF Names:TR106940Imported |
Organismi | Schistocephalus solidus (Tapeworm)Imported |
Taxonomic identifieri | 70667 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Cestoda › Eucestoda › Diphyllobothriidea › Diphyllobothriidae › Schistocephalus |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 143 | 2Fe-2S ferredoxin-typeInterPro annotationAdd BLAST | 94 | |
Domaini | 188 – 218 | 4Fe-4S ferredoxin-typeInterPro annotationAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotationARBA annotation
Family and domain databases
CDDi | cd00207, fer2, 1 hit |
Gene3Di | 1.10.1060.10, 1 hit 3.10.20.30, 1 hit |
InterProi | View protein in InterPro IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR006058, 2Fe2S_fd_BS IPR017896, 4Fe4S_Fe-S-bd IPR017900, 4Fe4S_Fe_S_CS IPR012675, Beta-grasp_dom_sf IPR009051, Helical_ferredxn IPR004489, Succ_DH/fum_Rdtase_Fe-S IPR025192, Succ_DH/fum_Rdtase_N |
Pfami | View protein in Pfam PF13085, Fer2_3, 1 hit |
SUPFAMi | SSF46548, SSF46548, 1 hit SSF54292, SSF54292, 1 hit |
TIGRFAMsi | TIGR00384, dhsB, 1 hit |
PROSITEi | View protein in PROSITE PS00197, 2FE2S_FER_1, 1 hit PS51085, 2FE2S_FER_2, 1 hit PS00198, 4FE4S_FER_1, 1 hit PS51379, 4FE4S_FER_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
A0A0X3PZW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SFPVFELIRD FAATVLVSIP GMNSLSVISP RLGCFLFQST RFASSAPRMK
60 70 80 90 100
KFAIYRYNPD KPSQKPYMQT YEVDLNECGP MVLDALIKIK NEMDPTLTFR
110 120 130 140 150
RSCREGICGS CAMNVDGGNR LACICAIDKN TSKTSKIYPL PHMYVVKDLV
160 170 180 190 200
PDMSNFYAQY RWIEPYLKKK EFKEENVGEK AFMQSIKDRD KIDGLYECIL
210 220 230 240 250
CACCSTSCPS YWWNSDKYLG PAVLMQAYRW MIDSRDDYTF ERLTQLQNKW
260 270 280 290
SVYRCHTIMN CTETCPKGLN PGKAIGEIKK MLIYYNSYKD KKPMNQMV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GEEE01010409 Transcribed RNA Translation: JAP52816.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GEEE01010409 Transcribed RNA Translation: JAP52816.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER01006 |
Family and domain databases
CDDi | cd00207, fer2, 1 hit |
Gene3Di | 1.10.1060.10, 1 hit 3.10.20.30, 1 hit |
InterProi | View protein in InterPro IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR006058, 2Fe2S_fd_BS IPR017896, 4Fe4S_Fe-S-bd IPR017900, 4Fe4S_Fe_S_CS IPR012675, Beta-grasp_dom_sf IPR009051, Helical_ferredxn IPR004489, Succ_DH/fum_Rdtase_Fe-S IPR025192, Succ_DH/fum_Rdtase_N |
Pfami | View protein in Pfam PF13085, Fer2_3, 1 hit |
SUPFAMi | SSF46548, SSF46548, 1 hit SSF54292, SSF54292, 1 hit |
TIGRFAMsi | TIGR00384, dhsB, 1 hit |
PROSITEi | View protein in PROSITE PS00197, 2FE2S_FER_1, 1 hit PS51085, 2FE2S_FER_2, 1 hit PS00198, 4FE4S_FER_1, 1 hit PS51379, 4FE4S_FER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0X3PZW1_SCHSO | |
Accessioni | A0A0X3PZW1Primary (citable) accession number: A0A0X3PZW1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 13, 2016 |
Last sequence update: | April 13, 2016 | |
Last modified: | February 10, 2021 | |
This is version 17 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |