Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 19 (31 Jul 2019)
Sequence version 1 (16 Mar 2016)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Histidine kinase

Gene

ATB93_11585

Organism
Sphingomonas sp. WG
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_001469845:G1EP0-1991-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Histidine kinaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:ATB93_11585Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSphingomonas sp. WGImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1592629 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000052965 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei190 – 212HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8004-aspartylphosphatePROSITE-ProRule annotation1
Modified residuei9224-aspartylphosphatePROSITE-ProRule annotation1
Modified residuei10754-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

PhosphoproteinPROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini479 – 699Histidine kinaseInterPro annotationAdd BLAST221
Domaini751 – 864Response regulatoryInterPro annotationAdd BLAST114
Domaini873 – 990Response regulatoryInterPro annotationAdd BLAST118
Domaini1020 – 1142Response regulatoryInterPro annotationAdd BLAST123

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili379 – 462Sequence analysisAdd BLAST84

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1755994at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00082 HisKA, 1 hit
cd00156 REC, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.450.40, 1 hit
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007891 CHASE3
IPR011006 CheY-like_superfamily
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C
IPR001789 Sig_transdc_resp-reg_receiver

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05227 CHASE3, 1 hit
PF13185 GAF_2, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF00072 Response_reg, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00344 BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00065 GAF, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00448 REC, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 3 hits
SSF55874 SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50109 HIS_KIN, 1 hit
PS50110 RESPONSE_REGULATORY, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0W1QKD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRRNRVRAS SSSSAWSLLG FFVGLAFFLG SGLIAVLNVQ SLRESDAAIR
60 70 80 90 100
RSHGVLIALD TLLSSVQDAE TGQRGYLLTG SRAYLEPYSA ATNLLPPRLK
110 120 130 140 150
AVSDRIGDNE TQQANLVQLR HHIDMKLAEL RESIEVRRDQ GLSAALAIVA
160 170 180 190 200
TDRGKATMDA IRAQLSAMMQ EEVRIRRLRL EEMATASRTA IASAVVSSLI
210 220 230 240 250
GAGLTLLMFP LFRRNARARA REAWIQAGQL GLSAAVRGDK TTEEIGAAVL
260 270 280 290 300
RYLADYLGFE AGALFKKEDG RFHRIATLGV PADAALPQGF APHDGLLGRV
310 320 330 340 350
AAEGEAMLLD DVPEGYLTIG SGFGQDRPRH LMIVPAKADD RVNAVLELGF
360 370 380 390 400
FHPVDDAALE LLDRASPGIG VALRSARFRA QLQAALEHSR RQAAELQTQS
410 420 430 440 450
EELQVNNEEL EEQSRALRES QAMLEQQQVE LEQTNSQLEE QAQALENQRD
460 470 480 490 500
ALERGSAQLL AKTRELEQAS QYKSDFLANM SHELRTPLNS LLILSKLLGD
510 520 530 540 550
NAPANLTPEQ VKFARTIESS GNDLLTLIND ILDLSKIEAG HVDVRAEPVS
560 570 580 590 600
LPRLANDLRQ LFQPVAEQRA LGFEIVLEEG AARGIETDRL RLEQILKNLL
610 620 630 640 650
SNALKFTEKG SVRLRVRAVA GDRLAFAVED TGIGVTEEQQ RRIFEAFHQA
660 670 680 690 700
DGTINRRYGG TGLGLSISRE LARLLGGSIA LESRPGEGST FTLTLPARYD
710 720 730 740 750
PAAVAPREAG AIAAAPPAAA SAPLASAASP RPAAGWSLED DRERLAPGAR
760 770 780 790 800
QLLVIEDDPV FASIVCDLSR ELGFQCLIAS SADEAMRLAR QYRPSAVVLD
810 820 830 840 850
LGLPDQSGLT VLDRLKQDSE TRHIPIHVIS AADQSQTALS LGAVGYHVKP
860 870 880 890 900
IRREQLADVL EGLQARTATR MRRVLIVEDD PVQRDAVARL LQSDDVETIG
910 920 930 940 950
VGTAVECLER LRTETFDCMV LDLSLPDASG HSLLETLSAE EGAHGFPPVI
960 970 980 990 1000
VYTGRELTAD DEQQLRRHSS SIIIKGAKSP ERLLDEVSLF LHQVVSELPS
1010 1020 1030 1040 1050
AQQAMILNAR RRDAVLEGRR VMIVEDDIRN VYSLTSVLEP RGVEVRIARN
1060 1070 1080 1090 1100
GQEALDALAA AAADPEDGID LVLMDVMMPV MDGLSATRAI RGDGRWAKLP
1110 1120 1130 1140
IIMLTAKAMP DDQERCIEAG ANDYMAKPID VDKLLSLVRV WMPR
Length:1,144
Mass (Da):124,791
Last modified:March 16, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0108DAEEE1EF8C49
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LNOS01000039 Genomic DNA Translation: KTF68949.1

NCBI Reference Sequences

More...
RefSeqi
WP_050990188.1, NZ_LNOS01000039.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
KTF68949; KTF68949; ATB93_11585

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LNOS01000039 Genomic DNA Translation: KTF68949.1
RefSeqiWP_050990188.1, NZ_LNOS01000039.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKTF68949; KTF68949; ATB93_11585

Phylogenomic databases

OrthoDBi1755994at2

Enzyme and pathway databases

BioCyciGCF_001469845:G1EP0-1991-MONOMER

Family and domain databases

CDDicd00082 HisKA, 1 hit
cd00156 REC, 3 hits
Gene3Di3.30.450.40, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR007891 CHASE3
IPR011006 CheY-like_superfamily
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF05227 CHASE3, 1 hit
PF13185 GAF_2, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF00072 Response_reg, 3 hits
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00065 GAF, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00448 REC, 3 hits
SUPFAMiSSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 3 hits
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit
PS50110 RESPONSE_REGULATORY, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0W1QKD4_9SPHN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0W1QKD4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 16, 2016
Last sequence update: March 16, 2016
Last modified: July 31, 2019
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again