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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

AO440_000530

Organism
Candida glabrata (Yeast) (Torulopsis glabrata)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (AO440_000981), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (AO440_002829), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (AO440_000530)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand2Fe-2SUniRule annotation, 3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, UbiquinoneImported

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:AO440_000530Imported
OrganismiCandida glabrata (Yeast) (Torulopsis glabrata)Imported
Taxonomic identifieri5478 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000054886 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0W0DLA1
SMRiA0A0W0DLA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotation

Phylogenomic databases

PhylomeDBiA0A0W0DLA1

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0W0DLA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFMLRVSRRG LATATSVPRL KTFKIYRWNP DKPTEKPHLQ EYKVDLEDCG
60 70 80 90 100
PMVLDALLKI KNEQDATLTF RRSCREGICG SCAMNIGGAN TLACLCKIDQ
110 120 130 140 150
DESKTTKIYP LPHMFIVKDL VPDLTGFYQQ YKSIQPYLQR TDYPADGKEV
160 170 180 190 200
LQSIDDRKKL DGLYECILCA CCSTSCPSYW WNQEEYLGPA VLMQAYRWLI
210 220 230 240 250
DSRDQATKAR RTMLQNSMSL YRCHTIMNCT RTCPKGLNPG RSIAEIKKQL

AFD
Length:253
Mass (Da):29,054
Last modified:March 16, 2016 - v1
Checksum:i2557E1940B402EA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LLZZ01000144 Genomic DNA Translation: KTA99486.1

Genome annotation databases

EnsemblFungiiKTA99486; KTA99486; AO440_000530

Similar proteinsi

Entry informationi

Entry nameiA0A0W0DLA1_CANGB
AccessioniPrimary (citable) accession number: A0A0W0DLA1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 16, 2016
Last sequence update: March 16, 2016
Last modified: February 28, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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