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Protein

Lipoate--protein ligase

Gene

ACH52_2302

Organism
Eubacterium limosum
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate.SAAS annotation

Pathwayi: protein lipoylation via exogenous pathway

This protein is involved in step 2 of the subpathway that synthesizes protein N(6)-(lipoyl)lysine from lipoate.SAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Lipoate--protein ligase (ACH52_2302), Lipoate--protein ligase (SAMN04515624_10199)
This subpathway is part of the pathway protein lipoylation via exogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from lipoate, the pathway protein lipoylation via exogenous pathway and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00537;UER00595

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoate--protein ligaseSAAS annotation (EC:6.3.1.20SAAS annotation)
Gene namesi
ORF Names:ACH52_2302Imported
OrganismiEubacterium limosumImported
Taxonomic identifieri1736 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
Proteomesi
  • UP000061973 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 214BPL/LPL catalyticInterPro annotationAdd BLAST188

Family and domain databases

InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR019491 Lipoate_protein_ligase_C
IPR004562 LipoylTrfase_LipoateP_Ligase
PANTHERiPTHR12561 PTHR12561, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PF10437 Lip_prot_lig_C, 1 hit
TIGRFAMsiTIGR00545 lipoyltrans, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0U3FC00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIFINNTYST DPTFNLAFEE YVFESMDQNE TYFMLWQNDH AIIVGKHQNT
60 70 80 90 100
IEEINQDFVK EQGIKVVRRL TGGGAVYHDL GNLNFTFIGN NDSGKPFDFQ
110 120 130 140 150
SFTRPVVKAL QSLGVNAEFN GRNDITIDGK KFSGNSQYAK RGRVLHHGTV
160 170 180 190 200
LFNSKLDTVQ NALKVKKDKI ESKGVKSVKS RVTNIADYLE PGFTLEDFKK
210 220 230 240 250
ALVSYMFEDG ELEERSLTEA DITAIKKLQE EKYATWEWNY GRSPEYNLRR
260 270 280 290 300
ERKYPCGLVT VLMTVDRGII KDIHFYGDFF GNGDITKLEK QLVGSKPEEG
310 320
VLRRLLKDND LSDYINGMTD DEFIDLMLY
Length:329
Mass (Da):37,783
Last modified:March 16, 2016 - v1
Checksum:i59BBE477C27F0A55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011914 Genomic DNA Translation: ALU15061.1
RefSeqiWP_058694907.1, NZ_CP011914.1

Genome annotation databases

EnsemblBacteriaiALU15061; ALU15061; ACH52_2302
PATRICifig|1736.8.peg.2399

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011914 Genomic DNA Translation: ALU15061.1
RefSeqiWP_058694907.1, NZ_CP011914.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiALU15061; ALU15061; ACH52_2302
PATRICifig|1736.8.peg.2399

Enzyme and pathway databases

UniPathwayi
UPA00537;UER00595

Family and domain databases

InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR019491 Lipoate_protein_ligase_C
IPR004562 LipoylTrfase_LipoateP_Ligase
PANTHERiPTHR12561 PTHR12561, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PF10437 Lip_prot_lig_C, 1 hit
TIGRFAMsiTIGR00545 lipoyltrans, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0U3FC00_EUBLI
AccessioniPrimary (citable) accession number: A0A0U3FC00
Entry historyiIntegrated into UniProtKB/TrEMBL: March 16, 2016
Last sequence update: March 16, 2016
Last modified: September 27, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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