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Protein
Submitted name:

Probable global transcription activator SNF2L2

Gene

SMARCA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Probable global transcription activator SNF2L2Imported
Gene namesi
Name:SMARCA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11098 SMARCA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000080503

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500671435425 – 245Sequence analysisAdd BLAST221

Proteomic databases

PeptideAtlasiA0A0U1RQX3

Expressioni

Gene expression databases

ExpressionAtlasiA0A0U1RQX3 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 193BromoInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili38 – 58Sequence analysisAdd BLAST21
Coiled coili203 – 233Sequence analysisAdd BLAST31

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00550000074659

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR030088 SMARCA2
PANTHERiPTHR10799:SF541 PTHR10799:SF541, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 34 potential isoforms that are computationally mapped.iShow all

A0A0U1RQX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRLAARCFA GLLILSPLTV ISDSRPADSG KAIEDGNLEE MEEEVRLKKR
60 70 80 90 100
KRRRNVDKDP AKEDVEKAKK RRGRPPAEKL SPNPPKLTKQ MNAIIDTVIN
110 120 130 140 150
YKDRCNVEKV PSNSQLEIEG NSSGRQLSEV FIQLPSRKEL PEYYELIRKP
160 170 180 190 200
VDFKKIKERI RNHKYRSLGD LEKDVMLLCH NAQTFNLEGS QIYEDSIVLQ
210 220 230 240
SVFKSARQKI AKEEESEDES NEEEEEEDEE ESESEAKSVK VKIKL
Length:245
Mass (Da):28,257
Last modified:February 17, 2016 - v1
Checksum:i2134D80023C9DFD3
GO

Computationally mapped potential isoform sequencesi

There are 34 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P51531SMCA2_HUMAN
Probable global transcription activ...
SMARCA2 BAF190B, BRM, SNF2A, SNF2L2
1,590Annotation score:
F6VDE0F6VDE0_HUMAN
Probable global transcription activ...
SMARCA2
1,514Annotation score:
A0A1B0GWA8A0A1B0GWA8_HUMAN
Probable global transcription activ...
SMARCA2
279Annotation score:
A0A1B0GU54A0A1B0GU54_HUMAN
Probable global transcription activ...
SMARCA2
288Annotation score:
A0A0U1RQZ9A0A0U1RQZ9_HUMAN
Probable global transcription activ...
SMARCA2
1,428Annotation score:
B1ALF6B1ALF6_HUMAN
Probable global transcription activ...
SMARCA2
278Annotation score:
B4DNT1B4DNT1_HUMAN
Probable global transcription activ...
SMARCA2
276Annotation score:
F6XE55F6XE55_HUMAN
Probable global transcription activ...
SMARCA2
228Annotation score:
A0A0U1RQU0A0A0U1RQU0_HUMAN
Probable global transcription activ...
SMARCA2
200Annotation score:
A0A0U1RQW7A0A0U1RQW7_HUMAN
Probable global transcription activ...
SMARCA2
229Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei245Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138755 Genomic DNA No translation available.
AL359076 Genomic DNA No translation available.
AL591644 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000634435; ENSP00000489212; ENSG00000080503

Similar proteinsi

Entry informationi

Entry nameiA0A0U1RQX3_HUMAN
AccessioniPrimary (citable) accession number: A0A0U1RQX3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: September 12, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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