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UniProtKB - A0A0U1RQM2 (A0A0U1RQM2_HUMAN)
Protein
Submitted name:
Forkhead box protein P2
Gene
FOXP2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 505 – 578 | Fork-headPROSITE-ProRule annotationAdd BLAST | 74 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- animal organ development Source: UniProt
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotation, RepressorARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Forkhead box protein P2Imported |
Gene namesi | Name:FOXP2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13875, FOXP2 |
VEuPathDBi | HostDB:ENSG00000128573 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 505 – 578 | Fork-headInterPro annotationAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 46 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 282 – 339 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 439 – 466 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 650 – 669 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 679 – 716 | DisorderedSequence analysisAdd BLAST | 38 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 141 – 191 | Sequence analysisAdd BLAST | 51 | |
Coiled coili | 194 – 217 | Sequence analysisAdd BLAST | 24 | |
Coiled coili | 389 – 409 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 289 – 328 | Polar residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 651 – 666 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 702 – 716 | Acidic residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155480 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
A0A0U1RQM2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL
60 70 80 90 100
HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT
110 120 130 140 150
PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL
160 170 180 190 200
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QHPGKQAKEQ
210 220 230 240 250
QQQQQQQQQQ LAAQQLVFQQ QLLQMQQLQQ QQHLLSLQRQ GLISIPPGQA
260 270 280 290 300
ALPVQSLPQA GLSPAEIQQL WKEVTGVHSM EDNGIKHGGL DLTTNNSSST
310 320 330 340 350
TSSNTSKASP PITHHSIVNG QSSVLSARRD SSSHEETGAS HTLYGHGVCK
360 370 380 390 400
WPGCESICED FGQFLKHLNN EHALDDRSTA QCRVQMQVVQ QLEIQLSKER
410 420 430 440 450
ERLQAMMTHL HMRPSEPKPS PKPLNLVSSV TMSKNMLETS PQSLPQTPTT
460 470 480 490 500
PTAPVTPITQ GPSVITPASV PNVGAIRRRH SDKYNIPMSS EIAPNYEFYK
510 520 530 540 550
NADVRPPFTY ATLIRQAIME SSDRQLTLNE IYSWFTRTFA YFRRNAATWK
560 570 580 590 600
NAVRHNLSLH KCFVRVENVK GAVWTVDEVE YQKRRSQKIT GSPTLVKNIP
610 620 630 640 650
TSLGYGAALN ASLQAALAES SLPLLSNPGL INNASSGLLQ AVHEDLNGSL
660 670 680 690 700
DHIDSNGNSS PGCSPQPHIH SIHVKEEPVI AEDEDCPMSL VTTANHSPEL
710
EDDREIEEEP LSEDLE
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO15409 | FOXP2_HUMAN | Forkhead box protein P2 | FOXP2 CAGH44, TNRC10 | 715 | Annotation score: | ||
A8MUV4 | A8MUV4_HUMAN | Forkhead box protein P2 | FOXP2 | 694 | Annotation score: | ||
Q0PRL4 | Q0PRL4_HUMAN | Forkhead box P2 variant 3 | FOXP2 | 530 | Annotation score: | ||
A0A0U1RQE0 | A0A0U1RQE0_HUMAN | Forkhead box protein P2 | FOXP2 | 589 | Annotation score: | ||
A0A0U1RQR8 | A0A0U1RQR8_HUMAN | Forkhead box protein P2 | FOXP2 | 698 | Annotation score: | ||
A0A0U1RQY3 | A0A0U1RQY3_HUMAN | Forkhead box protein P2 | FOXP2 | 712 | Annotation score: | ||
Q8N6B5 | Q8N6B5_HUMAN | Forkhead box P2, isoform CRA_d | FOXP2 hCG_1813384 | 456 | Annotation score: | ||
Q75MZ5 | Q75MZ5_HUMAN | Forkhead box P2, isoform CRA_a | FOXP2 hCG_1813384 | 67 | Annotation score: | ||
A0A0U1RQE6 | A0A0U1RQE6_HUMAN | Forkhead box protein P2 | FOXP2 | 228 | Annotation score: | ||
A8MTU2 | A8MTU2_HUMAN | Forkhead box protein P2 | FOXP2 | 171 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073626 Genomic DNA No translation available. AC074000 Genomic DNA No translation available. AC092148 Genomic DNA No translation available. AC092606 Genomic DNA No translation available. KF458557 Genomic DNA No translation available. KF458560 Genomic DNA No translation available. KF458565 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000635638; ENSP00000489073; ENSG00000128573 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073626 Genomic DNA No translation available. AC074000 Genomic DNA No translation available. AC092148 Genomic DNA No translation available. AC092606 Genomic DNA No translation available. KF458557 Genomic DNA No translation available. KF458560 Genomic DNA No translation available. KF458565 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A0U1RQM2 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A0U1RQM2 |
Protocols and materials databases
Antibodypediai | 672, 473 antibodies from 40 providers |
Genome annotation databases
Ensembli | ENST00000635638; ENSP00000489073; ENSG00000128573 |
Organism-specific databases
HGNCi | HGNC:13875, FOXP2 |
OpenTargetsi | ENSG00000128573 |
VEuPathDBi | HostDB:ENSG00000128573 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155480 |
Miscellaneous databases
ChiTaRSi | FOXP2, human |
Gene expression databases
ExpressionAtlasi | A0A0U1RQM2, baseline and differential |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0U1RQM2_HUMAN | |
Accessioni | A0A0U1RQM2Primary (citable) accession number: A0A0U1RQM2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | January 19, 2022 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |