UniProtKB - A0A0U1RQC9 (A0A0U1RQC9_HUMAN)
Cellular tumor antigen p53
TP53
Functioni
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
UniRule annotationCofactori
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- transcription cis-regulatory region binding Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: UniProt
- protein tetramerization Source: InterPro
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotation |
Biological process | ApoptosisUniRule annotationARBA annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Cellular tumor antigen p53UniRule annotation |
Gene namesi | Name:TP53 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11998, TP53 |
VEuPathDBi | HostDB:ENSG00000141510 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 373 – 392 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
CytoplasmUniRule annotation, Membrane, NucleusUniRule annotationPTM / Processingi
Keywords - PTMi
Isopeptide bondARBA annotation, Ubl conjugationARBA annotationProteomic databases
PeptideAtlasi | A0A0U1RQC9 |
Interactioni
Subunit structurei
Binds DNA as a homotetramer.
UniRule annotationProtein-protein interaction databases
IntActi | A0A0U1RQC9, 1 interactor |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 20 | TAD2InterPro annotationAdd BLAST | 20 | |
Domaini | 61 – 249 | P53InterPro annotationAdd BLAST | 189 | |
Domaini | 280 – 318 | P53_tetramerInterPro annotationAdd BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 56 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 243 – 286 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 315 – 338 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 25 – 53 | Pro residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 243 – 262 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 266 – 280 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00950000183153 |
Family and domain databases
CDDi | cd08367, P53, 1 hit |
Gene3Di | 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR040926, p53_TAD2 IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR002117, p53_tumour_suppressor |
PANTHERi | PTHR11447, PTHR11447, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF07710, P53_tetramer, 1 hit PF18521, TAD2, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MDDLMLSPDD IEQWFTEDPG PDEAPRMPEA APPVAPAPAA PTPAAPAPAP
60 70 80 90 100
SWPLSSSVPS QKTYQGSYGF RLGFLHSGTA KSVTCTYSPA LNKMFCQLAK
110 120 130 140 150
TCPVQLWVDS TPPPGTRVRA MAIYKQSQHM TEVVRRCPHH ERCSDSDGLA
160 170 180 190 200
PPQHLIRVEG NLRVEYLDDR NTFRHSVVVP YEPPEVGSDC TTIHYNYMCN
210 220 230 240 250
SSCMGGMNRR PILTIITLED SSGNLLGRNS FEVRVCACPG RDRRTEEENL
260 270 280 290 300
RKKGEPHHEL PPGSTKRALP NNTSSSPQPK KKPLDGEYFT LQIRGRERFE
310 320 330 340 350
MFRELNEALE LKDAQAGKEP GGSRAHSREC QTLSPGDPDP PLSETFNLNI
360 370 380 390 400
CPYPAGKLEL LKLSPCPCLC RQVTLMSFLF FFLIFFYFRL YWGIIDPPKL
410
HTFKVCSVMI
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP04637 | P53_HUMAN | Cellular tumor antigen p53 | TP53 P53 | 393 | Annotation score: | ||
E7EQX7 | E7EQX7_HUMAN | Cellular tumor antigen p53 | TP53 | 285 | Annotation score: | ||
J3KP33 | J3KP33_HUMAN | Cellular tumor antigen p53 | TP53 | 343 | Annotation score: | ||
E7EMR6 | E7EMR6_HUMAN | Cellular tumor antigen p53 | TP53 | 165 | Annotation score: | ||
S4R334 | S4R334_HUMAN | Cellular tumor antigen p53 | TP53 | 143 | Annotation score: | ||
A0A087X1Q1 | A0A087X1Q1_HUMAN | Cellular tumor antigen p53 | TP53 | 234 | Annotation score: | ||
E9PFT5 | E9PFT5_HUMAN | Cellular tumor antigen p53 | TP53 | 155 | Annotation score: | ||
E9PCY9 | E9PCY9_HUMAN | Cellular tumor antigen p53 | TP53 | 127 | Annotation score: | ||
A0A087WT22 | A0A087WT22_HUMAN | Cellular tumor antigen p53 | TP53 | 187 | Annotation score: | ||
A0A087WXZ1 | A0A087WXZ1_HUMAN | Cellular tumor antigen p53 | TP53 | 182 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. AC087388 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000635293.1; ENSP00000488924.1; ENSG00000141510.18 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. AC087388 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A0U1RQC9 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0A0U1RQC9, 1 interactor |
Proteomic databases
PeptideAtlasi | A0A0U1RQC9 |
Genome annotation databases
Ensembli | ENST00000635293.1; ENSP00000488924.1; ENSG00000141510.18 |
Organism-specific databases
HGNCi | HGNC:11998, TP53 |
OpenTargetsi | ENSG00000141510 |
VEuPathDBi | HostDB:ENSG00000141510 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183153 |
Miscellaneous databases
ChiTaRSi | TP53, human |
Gene expression databases
ExpressionAtlasi | A0A0U1RQC9, baseline and differential |
Family and domain databases
CDDi | cd08367, P53, 1 hit |
Gene3Di | 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR040926, p53_TAD2 IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR002117, p53_tumour_suppressor |
PANTHERi | PTHR11447, PTHR11447, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF07710, P53_tetramer, 1 hit PF18521, TAD2, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0U1RQC9_HUMAN | |
Accessioni | A0A0U1RQC9Primary (citable) accession number: A0A0U1RQC9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | May 25, 2022 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |