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Entry version 43 (29 Sep 2021)
Sequence version 1 (17 Feb 2016)
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Protein

Transmembrane channel-like protein

Gene

Tmc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ion channel (PubMed:27478019, PubMed:30853433, PubMed:31184585, PubMed:32649914).

Component of mechanosensitive neurons that participates in proprioception, sensing food texture, and directing egg-laying site selection (oviposition) (PubMed:27478019, PubMed:27298354, PubMed:30853433, PubMed:31184585, PubMed:32649914).

Component of multi-dendritic neurons of the labellum (md-L) where it is required for sensing the hardness and viscosity of their food, enabling them to behaviorally discriminate their preferred softness and smoothness from harder and stickier food options (PubMed:27478019).

Required as part of oviposition site selection process to relay mechanosensory and chemosensory information on the hardness and sweetness of potential egg-laying substrates, thus ensuring females select the most optimal site for their eggs survival (PubMed:31184585, PubMed:32649914).

Females determine the softest substrate for their eggs first by making a coarse evaluation of substrate hardness using mechanosensitive channels nan and Piezo in the leg tarsal bristles, followed by a much finer assessment using nan, iav and Tmc mechanosensitive channels on the labellum (PubMed:31184585, PubMed:32649914).

This protein is required to sense subtle differences in substrate stiffness (between 0.25% and 0.3% agarose), likely acting in the md-L neurons (PubMed:32649914).

Also required in neurons on the labellum, including the md-Ls, and possibly in the brain, to inhibit discrimination of egg-laying substrates of different hardness if the substrate contains sucrose (PubMed:32649914).

During oviposition evaluation, activation of sweet neurons by sucrose enhances the activity of the Tmc neurons resulting in females losing their softness preference in favor of egg-laying sites that contain sucrose (PubMed:32649914).

Acts in the larvae peripheral sensory neurons, to contribute to proprioception and sensory feedback for normal forward crawling behavior (PubMed:27298354, PubMed:30853433).

Required for the normal activity of the proprioceptive sensory dendrites, ddaE which show preferential responses to forward locomotion, and ddaD which show preferential responses to backward locomotion (PubMed:30853433).

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.17.4.9, the calcium-dependent chloride channel (ca-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane channel-like protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmc1 PublicationImported
ORF Names:CG46121Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0267796, Tmc

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
VectorBase:FBgn0267796

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 353CytoplasmicCuratedAdd BLAST353
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Topological domaini375 – 395ExtracellularCuratedAdd BLAST21
Transmembranei396 – 418HelicalSequence analysisAdd BLAST23
Topological domaini419 – 432CytoplasmicCuratedAdd BLAST14
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Topological domaini454 – 526ExtracellularCuratedAdd BLAST73
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 567CytoplasmicCuratedAdd BLAST20
Transmembranei568 – 588HelicalSequence analysisAdd BLAST21
Topological domaini589 – 599ExtracellularCuratedAdd BLAST11
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Topological domaini621 – 1308CytoplasmicCuratedAdd BLAST688
Transmembranei1309 – 1329HelicalSequence analysisAdd BLAST21
Topological domaini1330 – 1358ExtracellularCuratedAdd BLAST29
Transmembranei1359 – 1379HelicalSequence analysisAdd BLAST21
Topological domaini1380 – 1423CytoplasmicCuratedAdd BLAST44
Transmembranei1424 – 1444HelicalSequence analysisAdd BLAST21
Topological domaini1445 – 2036ExtracellularCuratedAdd BLAST592

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable and appear morphologically normal (PubMed:27478019). Adults display a significant reduction in the electrophysiological responses of multi-dendritic neurons of the labellum (md-L) to mechanical stimuli (PubMed:27478019). Adults are unable to discriminate between the preferred softness (1% agarose) or smoothness (sucrose solution only) from harder or stickier food options (PubMed:27478019). Adult females display a reduced ability to discriminate between small differences in egg-laying substrate stiffness (PubMed:32649914). Larvae display abnormal locomotion behaviors that likely result from the loss of proprioceptive feedback (PubMed:27298354, PubMed:30853433). Displays reduced sensitivity to movement direction due to decreased activity of the dorsal proprioceptors neurons ddaD, which are activated during backward movement, and ddaE neurons which are activated during forward movement (PubMed:30853433). As a consequence, larvae crawling speed is reduced due to increased head curl behavior and increased backward locomotion (PubMed:27298354). No obvious defects in larvae dendrite morphology of class I da neurons or axon targeting of neurons in the ventral nerve cord (PubMed:27298354). Adults display a normal avoidance of bitter tastes such as quinine, denatonium, strychnine and berberine, and L4 and S6 sensilla display normal electrophysiological responses to salt, sucrose and caffeine (PubMed:27478019).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004539241 – 2036Transmembrane channel-like proteinAdd BLAST2036

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
M9NDN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in multi-dendritic neurons of the labellum (md-L), which extend elaborate dendritic arbors innervating the bases of taste hairs (at protein level) (PubMed:27478019). In larvae, expressed in class I and class II dendritic arborization (da) neurons and bipolar dendrite (bd) neurons (at protein level) (PubMed:27298354). In adults, expressed in various sensory neurons including those in the mouth parts, olfactory neurons in the antenna, wing bristle neurons, haltere neurons, arista neurons, and many other sensory neurons, including a subset of chordotonal (Cho) neurons (PubMed:27478019, PubMed:27298354). Expressed in md-L axon terminals, including those that project into the subesophageal zone (SEZ) (PubMed:27478019, PubMed:31184585). Also expressed in a small number of local neurons in the adult ventral nerve cord (VNC), and projections extending from a few neurons in the legs or wing hinges (PubMed:27478019). In the adult mouth, expressed in a few multi-dendritic neurons of the ventral cibarial sensory organ (VCSO); the multiple elaborate dendritic branches form a brush-like structure that faces the luminal side of the food-passing tunnel (PubMed:27478019). Also expressed in the oviduct and uterus of adult females (PubMed:32649914).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0036017, Expressed in anatomical structure and 14 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0U1QT59, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0U1QT59

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 178DisorderedSequence analysisAdd BLAST178
Regioni194 – 243DisorderedSequence analysisAdd BLAST50
Regioni789 – 839DisorderedSequence analysisAdd BLAST51
Regioni860 – 967DisorderedSequence analysisAdd BLAST108
Regioni996 – 1027DisorderedSequence analysisAdd BLAST32
Regioni1066 – 1143DisorderedSequence analysisAdd BLAST78
Regioni1186 – 1205DisorderedSequence analysisAdd BLAST20
Regioni1527 – 1572DisorderedSequence analysisAdd BLAST46
Regioni1592 – 1841DisorderedSequence analysisAdd BLAST250
Regioni1859 – 1990DisorderedSequence analysisAdd BLAST132

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi54 – 90Polar residuesSequence analysisAdd BLAST37
Compositional biasi113 – 135Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi136 – 150Polar residuesSequence analysisAdd BLAST15
Compositional biasi224 – 243Polar residuesSequence analysisAdd BLAST20
Compositional biasi860 – 913Polar residuesSequence analysisAdd BLAST54
Compositional biasi925 – 949Polar residuesSequence analysisAdd BLAST25
Compositional biasi950 – 965Acidic residuesSequence analysisAdd BLAST16
Compositional biasi996 – 1011Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1012 – 1027Polar residuesSequence analysisAdd BLAST16
Compositional biasi1069 – 1135Polar residuesSequence analysisAdd BLAST67
Compositional biasi1187 – 1205Polar residuesSequence analysisAdd BLAST19
Compositional biasi1527 – 1570Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi1598 – 1613Polar residuesSequence analysisAdd BLAST16
Compositional biasi1616 – 1645Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1724 – 1745Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1779 – 1793Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1804 – 1840Polar residuesSequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QQGX, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234608

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001915_0_0_1

Identification of Orthologs from Complete Genome Data

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OMAi
EPHPKSR

Database of Orthologous Groups

More...
OrthoDBi
73310at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038900, TMC
IPR012496, TMC_dom

The PANTHER Classification System

More...
PANTHERi
PTHR23302, PTHR23302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07810, TMC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform CImported (identifier: A0A0U1QT59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQNDEEPAAA AGTSGLSNGE SLRSPPAPAP RRPKPGILRL DIGKPRRSSG
60 70 80 90 100
GSVDFRCVGS SSSNGNTSNV ATGANSENNS GVTSPHQLSV TWAPPCDLDR
110 120 130 140 150
GGWQMQSSAD AKREFYKGQR GRRAASQEDH RSYELNDFPL QNQSSDAESC
160 170 180 190 200
HQEPHFAHQR SPGIGFDEDG GGGDIDDEES YTISVSAIMQ RRASVRGYRG
210 220 230 240 250
KRGSRSSRRA SSPMDHVLDS VERRRSSVYT TSSEEGTNQE STQEQIFENI
260 270 280 290 300
RLHKEVIQSV KLQPWPIRKK LKLVRQAKTY VARHEGALQE RFAMSRSTRD
310 320 330 340 350
LWARFKILMA ARWRHWKRET ASFLTVLIPW ELRIKEIESH FGSGVASYFT
360 370 380 390 400
FLRWLMWVNI MIAIPLVAFV IGPEYFATKH GETDPRKRMS DPEARVAGNL
410 420 430 440 450
FTFWEFEGYL KYSPMFYGYY SSTSGISTSG YKLPLAYFLT AVLVYIYSFV
460 470 480 490 500
ATLRKMAENS RNSKLSSKDD ECVFSWKLFT GWDFMIGHAE TAHNRIASVV
510 520 530 540 550
VGFKEALLEE AEKKKDNRNW RVILQRILVN ILVMGLLGLS GATVVLLVNH
560 570 580 590 600
SEDLAKHDNW LSRNAVNVTM TLLSFFLPMI FEALGLFENW HPRQQLRLQL
610 620 630 640 650
ARIMILNMLN LYSLMFSFIY KINSKEKPLQ MLKLENETNT MELKNLLSSI
660 670 680 690 700
EALRAMTPTT SLYGESTSDG LFDDSTSTAT WGEDGGGLFS TTAAAALIST
710 720 730 740 750
TVQRLKCYNM TVKCSKLRRN IISGKHLATT LMVLNLTTPA MVPPTLPTTL
760 770 780 790 800
PTTFPTTLPT TLPTTLPTAL PTTLPTTLPT TLPSTLATTT ATTSSIWSTT
810 820 830 840 850
EETSPTTTTT SPWTTLPPST TTTEATTTTE RATTTTEATS TTTLKITTAE
860 870 880 890 900
INSTLSDTTK PLGKSIDTEI PNSTTNSATL STIPATLNTT NLPLNSTTKL
910 920 930 940 950
TTTTSTEKPQ GEDNFIYTTG EDEGSYDYGS DSTSDAPDNN SYSDITDYSS
960 970 980 990 1000
EPSEIEDFDE QESTDQADDP LAKVLEQLDE NETKGRRKRA LAESPFFTSK
1010 1020 1030 1040 1050
YSRRHRNESA VSAGQPRETT ESVNATPSRW PFNWASFRQT TPRTTTTRRV
1060 1070 1080 1090 1100
PSGILTKEEW ERLRRLRGRI TTTTSTSTTS TTTRRPRWRY RTTTTELTST
1110 1120 1130 1140 1150
TEEESSTTES STDSSSPGST TNAFDSSSST TEEDEYTTTE GSENRPYYVG
1160 1170 1180 1190 1200
YVDISEMGST IYYDGDSEFL EECVITICPK GDDFFGSTTE SPDSTTQSSD
1210 1220 1230 1240 1250
SKQLTTVKLT PLERKQKRLK EVQLAIKQIQ TNLTTMCWET SLGQELSKVI
1260 1270 1280 1290 1300
VFDGLMSIVA PLCIDFLRAL FVRYVNQNWC WDMEKTFPQY GDFKIAENIL
1310 1320 1330 1340 1350
TLINNQGQVW MGIFFSPGLV LINLVKLMIM MYFRSWIVLT CNVPHEVVFK
1360 1370 1380 1390 1400
ASKSNNFYLS LLLTMLFLCV LPVGYAIVWL RPSWHCGPFS EYNRIAEFIT
1410 1420 1430 1440 1450
NTTRNALPKQ LHEPLDYLTS SSTVIPLLLL LILIIYYLVS LTGALREANQ
1460 1470 1480 1490 1500
DLRTQLQKER EEERKKIFKV PEVKQAEPTA TTLTNRWRKV LEASSPVTPT
1510 1520 1530 1540 1550
QPPDFDTEEY KNQARKELIS RIMKKALRKG SATSDEDSFV RRDDDDTDTE
1560 1570 1580 1590 1600
HQDSLPHDEE AKDKRFGLSR LQQIRRTRKP SLVDIVQIAK QERARAGSIV
1610 1620 1630 1640 1650
AGTSSSGTGN FPIKETHPKS RFKVEKHERK DRGSMKDKKD TRHRQSPQQQ
1660 1670 1680 1690 1700
QQPPPYESPK DNEHDPDTNS RIVSASLLRR HKEQAEGEEP PTTPDAPQTP
1710 1720 1730 1740 1750
NSPVEPVEQA LEESTPETPT LAKSKFHIVD EKKPPPHEVE DKPLPTPKES
1760 1770 1780 1790 1800
GSGGGSLGKF KFRKHKFKSN NVAAVKPEPE VFKFDERSVE RSSDVPATHA
1810 1820 1830 1840 1850
AEYLNNEPSG TEEQDRSLPS PTPSQGQGHH QRQLSVLSRQ GRKKIGNLLA
1860 1870 1880 1890 1900
LVREAVNLKK DDVEQAGSDE SPGPTTPTYL AYTPPPPPSV LSSVSSSTAL
1910 1920 1930 1940 1950
EMPPTPEPES PTPSAPLHFG SSTSSRAPSK PPKPPMVPAS ATAPTATMDD
1960 1970 1980 1990 2000
LEELDTAGPI TFPRRSDSHR RRTMRQDSQS SIWSDNIPTI TISTTGSDEC
2010 2020 2030
IVDAAAPQNG LPDPRSASPE PTVNIIRIDI ENEHEK
Length:2,036
Mass (Da):227,308
Last modified:February 17, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i942BE7480672B0C3
GO
Isoform DImported (identifier: A0A0U1QT59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.

Show »
Length:1,932
Mass (Da):216,669
Checksum:i1D866A0A059B0BA9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0612151 – 104Missing in isoform D. CuratedAdd BLAST104

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50239.5
AE014296 Genomic DNA Translation: AFH04369.1

NCBI Reference Sequences

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RefSeqi
NP_001303362.1, NM_001316433.1

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0347573; FBpp0312604; FBgn0267796

Database of genes from NCBI RefSeq genomes

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GeneIDi
26067066

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG46121

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50239.5
AE014296 Genomic DNA Translation: AFH04369.1
RefSeqiNP_001303362.1, NM_001316433.1

3D structure databases

SMRiA0A0U1QT59
ModBaseiSearch...

Protein family/group databases

TCDBi1.A.17.4.9, the calcium-dependent chloride channel (ca-clc) family

Proteomic databases

PaxDbiM9NDN5

Genome annotation databases

EnsemblMetazoaiFBtr0347573; FBpp0312604; FBgn0267796
GeneIDi26067066
KEGGidme:Dmel_CG46121

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26067066
FlyBaseiFBgn0267796, Tmc
VEuPathDBiVectorBase:FBgn0267796

Phylogenomic databases

eggNOGiENOG502QQGX, Eukaryota
GeneTreeiENSGT01030000234608
HOGENOMiCLU_001915_0_0_1
OMAiEPHPKSR
OrthoDBi73310at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
26067066, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26067066

Gene expression databases

BgeeiFBgn0036017, Expressed in anatomical structure and 14 other tissues
ExpressionAtlasiA0A0U1QT59, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR038900, TMC
IPR012496, TMC_dom
PANTHERiPTHR23302, PTHR23302, 1 hit
PfamiView protein in Pfam
PF07810, TMC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMC_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0U1QT59
Secondary accession number(s): M9NDN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 29, 2021
Last sequence update: February 17, 2016
Last modified: September 29, 2021
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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