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Entry version 22 (02 Jun 2021)
Sequence version 1 (17 Feb 2016)
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Protein

Phenylalanine aminomutase (L-beta-phenylalanine forming)

Gene

cctP

Organism
Talaromyces islandicus (Penicillium islandicum)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phenylalanine aminomutase; part of the gene cluster that mediates the biosynthesis of the mycotoxin cyclochlorotine, a hepatotoxic and carcinogenic cyclic chlorinated pentapeptide (PubMed:26954535).

Cyclochlorotine is formed by the nonproteinogenic amino acids L-2-aminobutyrate (2Abu), L-beta-phenylalanine (beta-Phe), the unique L-cis-3,4-dichloroproline Pro(Cl2) and two L-serines (Ser) (PubMed:26954535).

The condensation of the 5 building blocks is performed by the cyclochlorotine synthetase cctN, a nonribosomal peptide synthetase (PubMed:26954535).

The assembled linear pentapeptide is then assumed to be released through cyclization by the terminal condensation-like domain of cctN (PubMed:26954535).

Incorporation of the alternative substrates allo-threonine or alanine by the domains A3 or A1 respectively may lead to the production of the variants hydroxy-cyclochlorotine and deoxy-cyclochlorotine, respectively (PubMed:26954535).

CctP probably acts as a phenylalanine aminomutase and provides the uncommon building block beta-Phe (PubMed:26954535).

Furthermore, 2Abu can be synthesized from threonine by one of the threonine dehydratases and transaminases localized outside of the cluster (PubMed:26954535).

The biosynthesis of the unusual dichloroproline moiety remains elusive since the actual halogenase still awaits to be detected, with the possibility that proline halogenation is accomplished by a so far unknown type of halogenase (PubMed:26954535).

Finally, the cluster encoded transporters cctQ and cctS are most likely responsible for cyclochlorotine secretion and thereby may contribute to intrinsic resistance (PubMed:26954535).

The functions of the remaining proteins encoded by the cluster (cctM, cctO, cctR and cctG) have not been identified yet (PubMed:26954535).

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Mycotoxin biosynthesis

This protein is involved in Mycotoxin biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Mycotoxin biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei79Proton donor/acceptorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei232SubstrateBy similarity1
Binding sitei325SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processVirulence

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
5.4.3.10, 4619

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phenylalanine aminomutase (L-beta-phenylalanine forming)1 Publication (EC:5.4.3.101 Publication)
Short name:
PAM1 Publication
Alternative name(s):
Cyclochlorotine biosynthesis protein P1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cctP1 Publication
ORF Names:PISL3812_02621
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTalaromyces islandicus (Penicillium islandicum)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28573 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromycesTalaromyces sect. Islandici
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000054383 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004386701 – 997Phenylalanine aminomutase (L-beta-phenylalanine forming)Add BLAST997

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki177 ↔ 1795-imidazolinone (Ala-Gly)Curated
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1782,3-didehydroalanine (Ser)PROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.Curated

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0U1LSP0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PAL/histidase family.Curated

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
923557at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00332, PAL-HAL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.274.20, 1 hit
1.10.275.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001106, Aromatic_Lyase
IPR024083, Fumarase/histidase_N
IPR008948, L-Aspartase-like
IPR022313, Phe/His_NH3-lyase_AS
IPR005922, Phe_NH3-lyase
IPR023144, Phe_NH3-lyase_shielding_dom_sf
IPR021765, UstYa-like

The PANTHER Classification System

More...
PANTHERi
PTHR10362, PTHR10362, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00221, Lyase_aromatic, 1 hit
PF11807, UstYa, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48557, SSF48557, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01226, phe_am_lyase, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00488, PAL_HISTIDASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0U1LSP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQSAHLVK THQLWELLRH RTKTGSYELD GDSLHIADVV ATAQQTSTPR
60 70 80 90 100
LSEDPKVIKG LQDSVDVLFD HLAKGWYVYG VNTGFGGSAD SRTTEVIELQ
110 120 130 140 150
KALMQLTQTG ILTTPSDGSA IPGHSTPFEW VRAAMVVRCN ASLRGHSAVS
160 170 180 190 200
LPIIKAIINL LVHGLTPVVP LRGTVSASGD LMPLAYVTGS IEGNPDTLLE
210 220 230 240 250
KNGKVLPSPK ALQEAGLAPV FLGPKEGLGL INGTASSAGL GALVVAQAHS
260 270 280 290 300
LAFLTQVLTG GAVEALRGSS ESFHPFIARA RPHPGQIECA RNIAYFLRGS
310 320 330 340 350
HLSRDVLAPK DRRREDLAQD RYSLRSAPQW IGPQLEDLLL ADQQISIELN
360 370 380 390 400
SSCDNPLVDS ETNDIYYGCN FQAAAVTSAM EKVRLAMQMF GRMLFAQSTE
410 420 430 440 450
MIDVHLSGGL PANLAADNPS ISFTMKGVDI NMAAYMAELS YLANPMSSHV
460 470 480 490 500
QAAEMHNQSV NSMAFASARI SHDAIDVLTK MCACSVFTVC QALDLRALHM
510 520 530 540 550
AFIADATKAL ASTIELKFSA KVEAGQLNSL QMLIQAHVTR AWGLTGKLDL
560 570 580 590 600
HARCESLIDS ALPIVLCHVA GDVADIIEWK TQAIEVVWNV WTNTFASFSA
610 620 630 640 650
APHTSQLLGA GSRLLYNFVR KTLGVPFHEG FVEHPTADSQ TLHSRPKKTI
660 670 680 690 700
DILANLSDSS NSKRDIERER LKGEKPTRSI LITMEGKTSR YQDEAHDSAG
710 720 730 740 750
SFNEETEGLM SGLHRSTKKR KLSSIVKLAT PFLIVSFILN IVQLAYITVR
760 770 780 790 800
RPECYSLYAK LKEHEITVPF RYATEYSDDE HTHEEKDALW NAIDISEGFV
810 820 830 840 850
AISNDESDRL GLPRSKTFPW DANKGIYVSH GHHALHCTVL LHAYTYDAHQ
860 870 880 890 900
GKKPLVSYHH IEHCLDLLRQ DIMCYANDVM DYTPDHGDNF LTGEGQQRKC
910 920 930 940 950
RDWNKLSAWV KERSACYKTI NITRAGEDHG VAHQLDRYTY CPPGSPYEPL
960 970 980 990
IKAFKDLGRV NTGNLAADGF HELTPEELAA EAQAVAEHNK QILADEG
Length:997
Mass (Da):109,350
Last modified:February 17, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1C1522DF1873827
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CVMT01000002 Genomic DNA Translation: CRG85574.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CRG85574; CRG85574; PISL3812_02621

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CVMT01000002 Genomic DNA Translation: CRG85574.1

3D structure databases

SMRiA0A0U1LSP0
ModBaseiSearch...

Genome annotation databases

EnsemblFungiiCRG85574; CRG85574; PISL3812_02621

Phylogenomic databases

OrthoDBi923557at2759

Enzyme and pathway databases

BRENDAi5.4.3.10, 4619

Family and domain databases

CDDicd00332, PAL-HAL, 1 hit
Gene3Di1.10.274.20, 1 hit
1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR001106, Aromatic_Lyase
IPR024083, Fumarase/histidase_N
IPR008948, L-Aspartase-like
IPR022313, Phe/His_NH3-lyase_AS
IPR005922, Phe_NH3-lyase
IPR023144, Phe_NH3-lyase_shielding_dom_sf
IPR021765, UstYa-like
PANTHERiPTHR10362, PTHR10362, 1 hit
PfamiView protein in Pfam
PF00221, Lyase_aromatic, 1 hit
PF11807, UstYa, 1 hit
SUPFAMiSSF48557, SSF48557, 1 hit
TIGRFAMsiTIGR01226, phe_am_lyase, 1 hit
PROSITEiView protein in PROSITE
PS00488, PAL_HISTIDASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCTP_TALIS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0U1LSP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 18, 2017
Last sequence update: February 17, 2016
Last modified: June 2, 2021
This is version 22 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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