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Protein

Ribonuclease 3

Gene

rnc_1

Organism
Chlamydia trachomatis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48MagnesiumUniRule annotation1
Active sitei52UniRule annotation1
Metal bindingi121MagnesiumUniRule annotation1
Active sitei124UniRule annotation1
Metal bindingi124MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation
Biological processmRNA processingUniRule annotationSAAS annotation, rRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rnc_1Imported
Synonyms:rncUniRule annotationImported
ORF Names:ERS015772_00730Imported, ERS177788_00018Imported
OrganismiChlamydia trachomatisImported
Taxonomic identifieri813 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000038595 Componenti: Unassembled WGS sequence
  • UP000045537 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 135RNase IIIInterPro annotationAdd BLAST129
Domaini160 – 229DRBMInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribonuclease III family.SAAS annotation

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0U1CGP4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQHTVDIQAI ESKLNFTFSH PKLLITALTH PSYRNEFPSA EEDSERLEFL
60 70 80 90 100
GDAVLGLVVT EHLFLLFPAL NEGLLSTTRA ALVNAEACFE YTQKLSLGEH
110 120 130 140 150
LLIGRGEKMQ SHRGKISAYA NLFEAILGAV YLDGGLSPAR QIIVPLLPDK
160 170 180 190 200
ESILPLMLVN PKNRLQQFTQ QTLKVLPSYK ALPWKSEDGS PGYHVQVFVN
210 220 230
GDLWGEGFAG SKKEAEKLAA KQALSTHDNK N
Length:231
Mass (Da):25,567
Last modified:February 17, 2016 - v1
Checksum:i1B5DBE251561A1A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CSTN01000009 Genomic DNA Translation: CPR53518.1
CTBL01000001 Genomic DNA Translation: CQB84884.1
RefSeqiWP_009873095.1, NZ_CSTK01000002.1

Genome annotation databases

EnsemblBacteriaiCPR53518; CPR53518; ERS015772_00730
CQB84884; CQB84884; ERS177788_00018
GeneIDi35554597
PATRICifig|813.31.peg.323

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CSTN01000009 Genomic DNA Translation: CPR53518.1
CTBL01000001 Genomic DNA Translation: CQB84884.1
RefSeqiWP_009873095.1, NZ_CSTK01000002.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCPR53518; CPR53518; ERS015772_00730
CQB84884; CQB84884; ERS177788_00018
GeneIDi35554597
PATRICifig|813.31.peg.323

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0U1CGP4_CHLTH
AccessioniPrimary (citable) accession number: A0A0U1CGP4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: September 12, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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