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Protein

Alanine racemase

Gene

alr_1

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (ala_1), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (ala_2), Alanine racemase (alr_1), Alanine racemase (CHL72_01280), Alanine racemase (ala), Alanine racemase (alr2), Alanine racemase (alr_1), Alanine racemase (alr_2), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr_3), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr_2), Alanine racemase (alr_2), Alanine racemase (alr), Alanine racemase (alr_3), Alanine racemase (alr_1), Alanine racemase (alr), Multifunctional fusion protein (alr_2), Alanine racemase (alr_1), Alanine racemase (CHL73_05415), Alanine racemase (alr_1), Alanine racemase (alr), Alanine racemase (ala), Alanine racemase (alr), Alanine racemase (alr_2), Alanine racemase (alr_1), Alanine racemase (alr_1), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr_2), Alanine racemase (alr_1), Alanine racemase (alr_1), Alanine racemase (alr), Alanine racemase (ala), Alanine racemase (A4260_07550), Alanine racemase (alr_1), Alanine racemase (alr_2), Alanine racemase (ala), Alanine racemase (alr_2), Alanine racemase (CWI64_03870), Alanine racemase (alr_1), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr_3), Alanine racemase (alr_1), Alanine racemase (alr), Alanine racemase (ala), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr_2), Alanine racemase (alr), Alanine racemase (alr_1), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (ala), Alanine racemase (alr), Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei58Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Active sitei286Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei334Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr_1Imported
ORF Names:ERS232505_03726Imported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000248735 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58N6-(pyridoxal phosphate)lysineUniRule annotation1

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0T8XBS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKREIEWNAI IELGVRPMSL KYGRDTIVEV DLNAVKHNVK EFKKRVNDEN
60 70 80 90 100
IAMMAAVKAN GYGHGAVEVA KAAIEAGINQ LAVAFVDEAI ELREAGINVP
110 120 130 140 150
ILILGYTSVA AAEEAIQYDV MMTVYRSEDL QGINEIANRL QKKAQIQVKI
160 170 180 190 200
DTGMSRIGLQ EEEVKPFLEE LNRMEYVEVV GMFTHYSTAD EIDKSYTNMQ
210 220 230 240 250
TSLFEKAVNT AKELGIHIPY IHSSNSAGSM ELSNTFQNMV RVGIGIYGMY
260 270 280 290 300
PSKEVDHSVV SLQPALSLKS KVAHIKHAKK NRGVSYGNTY VTTGEEWIAT
310 320 330 340 350
IPIGYADGYN RQLSNKGHAL INGVRVPVIG RVCMDQLMLD VSKAMPVQVG
360 370 380 390 400
DEVVFYGKQG EENIAVEEIA DMLGTINYEV TCMLDRRIPR VYKENNETTA

IVNILRKN
Length:408
Mass (Da):45,425
Last modified:February 17, 2016 - v1
Checksum:i5ADF4E7DFF66FC7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CIDG01000134 Genomic DNA Translation: CKF62735.1

Genome annotation databases

EnsemblBacteriaiCKF79866; CKF79866; ERS232495_04231

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CIDG01000134 Genomic DNA Translation: CKF62735.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCKF79866; CKF79866; ERS232495_04231

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0T8XBS0_STREE
AccessioniPrimary (citable) accession number: A0A0T8XBS0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: October 10, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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