Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Octanoyl-[GcvH]:protein N-octanoyltransferase

Gene

lipL

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes.UniRule annotation

Miscellaneous

The reaction proceeds via a thioester-linked acyl-enzyme intermediate.UniRule annotation

Catalytic activityi

[Glycine cleavage system H]-N6-octanoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-octanoyl-L-lysine.UniRule annotation

Pathwayi: protein lipoylation via endogenous pathway

This protein is involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein].UniRule annotation This subpathway is part of the pathway protein lipoylation via endogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein lipoylation via endogenous pathway and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei117Acyl-thioester intermediateUniRule annotation1
Sitei129Lowers pKa of active site CysUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, LigaseImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Octanoyl-[GcvH]:protein N-octanoyltransferaseUniRule annotation (EC:2.3.1.204UniRule annotation)
Alternative name(s):
Octanoyl-[GcvH]:E2 amidotransferaseUniRule annotation
Gene namesi
Name:lipLUniRule annotationImported
ORF Names:ERS022071_02667Imported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000039956 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 197BPL/LPL catalyticInterPro annotationAdd BLAST186

Sequence similaritiesi

Belongs to the octanoyltransferase LipL family.UniRule annotation

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0T8P4X8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDTLCTSIG KGESAATMRS WVHHNTIVLG IQDSRLPHLE EGISFLKEND
60 70 80 90 100
FNVIVRNSGG LAVVLDEGVL NVSLLFQETE KGIDIDLGYD TMWHLIQEML
110 120 130 140 150
KDYDVTIEAK EIVGSYCPGS YDLSIRDQKF AGISQRRIRG GVAVQIYLCA
160 170 180 190 200
TGSGSERAAL VRDFYNLAIQ GEETRFTYPE IVPSTMASLS ELLGETITVQ
210 220 230 240
DLMMRLLKTL QQFAPKLTPS QLTIDEIPLY ETNLQRIIDR NNKALGLEK
Length:249
Mass (Da):27,819
Last modified:February 17, 2016 - v1
Checksum:i226DE36FFF8C83C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CLRF01000232 Genomic DNA Translation: CJQ24035.1

Genome annotation databases

EnsemblBacteriaiCJQ24035; CJQ24035; ERS022071_02667

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CLRF01000232 Genomic DNA Translation: CJQ24035.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCJQ24035; CJQ24035; ERS022071_02667

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0T8P4X8_STREE
AccessioniPrimary (citable) accession number: A0A0T8P4X8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: September 27, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again