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Entry version 22 (12 Aug 2020)
Sequence version 1 (17 Feb 2016)
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Protein
Submitted name:

Zinc finger protein 688 isoform 4

Gene

ZNF688

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein 688 isoform 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF688Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A0S2Z5X4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

A0A0S2Z5X4
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-16429014,EBI-11096309
BEND5 [Q7L4P6]3EBI-16429014,EBI-724373
BLZF1 [Q9H2G9]3EBI-16429014,EBI-2548012
CADPS [A2RRN7]3EBI-16429014,EBI-10179719
CALCOCO2 [Q13137]3EBI-16429014,EBI-739580
CARD9 - isoform 2 [Q9H257-2]3EBI-16429014,EBI-11530605
CARD9 - isoform 3 [Q9H257-3]3EBI-16429014,EBI-16431743
CBY2 - isoform 2 [Q8NA61-2]3EBI-16429014,EBI-11524851
CCDC36 [Q8IYA8]3EBI-16429014,EBI-8638439
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-16429014,EBI-10961624
CEP44 [Q9C0F1]3EBI-16429014,EBI-744115
CEP70 [Q8NHQ1]3EBI-16429014,EBI-739624
CEP72 [Q9P209]3EBI-16429014,EBI-739498
EHMT2 [Q96KQ7]3EBI-16429014,EBI-744366
FCHO1 [A0A0C3SFZ9]4EBI-16429014,EBI-11977403
FHL5 [Q5TD97]3EBI-16429014,EBI-750641
GOLGA2 [Q08379]6EBI-16429014,EBI-618309
GPRASP2 [Q96D09]3EBI-16429014,EBI-473189
HMBOX1 [Q6NT76]3EBI-16429014,EBI-2549423
HNRNPK [P61978]3EBI-16429014,EBI-304185
HNRNPK - isoform 2 [P61978-2]3EBI-16429014,EBI-7060731
KHDRBS2 [Q5VWX1]3EBI-16429014,EBI-742808
KHDRBS3 [O75525]3EBI-16429014,EBI-722504
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-16429014,EBI-14069005
KRT13 [P13646]3EBI-16429014,EBI-1223876
KRT15 [P19012]3EBI-16429014,EBI-739566
KRT31 [Q15323]3EBI-16429014,EBI-948001
KRT40 [Q6A162]3EBI-16429014,EBI-10171697
KRTAP10-9 [P60411]3EBI-16429014,EBI-10172052
KRTAP12-2 [P59991]3EBI-16429014,EBI-10176379
KRTAP4-2 [Q9BYR5]3EBI-16429014,EBI-10172511
LDOC1 [O95751]3EBI-16429014,EBI-740738
MAGED1 [Q9Y5V3]3EBI-16429014,EBI-716006
MDFI [Q99750]3EBI-16429014,EBI-724076
MEOX2 [Q6FHY5]3EBI-16429014,EBI-16439278
MID2 - isoform 2 [Q9UJV3-2]3EBI-16429014,EBI-10172526
MIPOL1 [Q8TD10]3EBI-16429014,EBI-2548751
MKRN3 [Q13064]3EBI-16429014,EBI-2340269
NOTCH2NLA [Q7Z3S9]3EBI-16429014,EBI-945833
PCBD1 [P61457]3EBI-16429014,EBI-740475
PLSCR1 [O15162]3EBI-16429014,EBI-740019
PNMA1 [Q8ND90]3EBI-16429014,EBI-302345
PNMA2 [Q9UL42]3EBI-16429014,EBI-302355
PSMA3 [P25788]3EBI-16429014,EBI-348380
PSTPIP1 [O43586]3EBI-16429014,EBI-1050964
REL - isoform 2 [Q04864-2]3EBI-16429014,EBI-10829018
RFX6 [Q8HWS3]3EBI-16429014,EBI-746118
RINT1 [Q6NUQ1]3EBI-16429014,EBI-726876
RPGRIP1 - isoform 4 [Q96KN7-4]3EBI-16429014,EBI-11525164
SPAG5 [Q96R06]3EBI-16429014,EBI-413317
SSX2IP [Q9Y2D8]3EBI-16429014,EBI-2212028
TADA2A [O75478]3EBI-16429014,EBI-742268
TCF4 - isoform SEF2-1D [P15884-3]3EBI-16429014,EBI-13636688
Isoform O75069-43EBI-16429014,EBI-10177480
TNS2 [Q63HR2]3EBI-16429014,EBI-949753
TRAF1 [Q13077]3EBI-16429014,EBI-359224
TRAF4 [Q9BUZ4]3EBI-16429014,EBI-3650647
TRIM23 [P36406]3EBI-16429014,EBI-740098
TRIM27 [P14373]6EBI-16429014,EBI-719493
TRIP6 [Q15654]6EBI-16429014,EBI-742327
USHBP1 [Q8N6Y0]3EBI-16429014,EBI-739895
WWP2 [O00308]3EBI-16429014,EBI-743923
ZC4H2 [Q9NQZ6]3EBI-16429014,EBI-747993

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A0A0S2Z5X4, 61 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 101KRABInterPro annotationAdd BLAST76
Domaini145 – 172C2H2-typeInterPro annotationAdd BLAST28
Domaini173 – 195C2H2-typeInterPro annotationAdd BLAST23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni62 – 97DisorderedSequence analysisAdd BLAST36
Regioni198 – 217DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi67 – 97PolyampholyteSequence analysisAdd BLAST31

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A0A0S2Z5X4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPPAPLLA PRPGETRPGC RKPGTVSFAD VAVYFSPEEW GCLRPAQRAL
60 70 80 90 100
YRDVMQETYG HLGALGDVPN RKEEEPEEVP RAKGPRKAPV KESPEVLVER
110 120 130 140 150
NPDPAISVAP ARAQPPKNAA WDPTTGAQPP APIPSMDAQA GQRRHVCTDC
160 170 180 190 200
GRRFTYPSLL VSHRRMHSGE RPFPCPECGM RFKRKFAVEA HQWIHRSCSG
210 220 230
GRRGRRPGIR AVPRAPVRGD RDPPVLFRHY PDIFEECG
Length:238
Mass (Da):26,455
Last modified:February 17, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BA5AEE1FD65471D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei238Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KU178872 mRNA Translation: ALQ34330.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU178872 mRNA Translation: ALQ34330.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA0A0S2Z5X4, 61 interactors

Proteomic databases

PeptideAtlasiA0A0S2Z5X4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF688, human

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 2 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0S2Z5X4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0S2Z5X4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: August 12, 2020
This is version 22 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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