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UniProtKB - A0A0S2Z4N0 (A0A0S2Z4N0_HUMAN)
Protein
Submitted name:
MADS box transcription enhancer factor 2, polypeptide A (Myocyte enhancer factor 2A), isoform CRA_d
Gene
MEF2A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor binding Source: Ensembl
- protein dimerization activity Source: InterPro
- protein kinase binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- cardiac conduction Source: Ensembl
- mitochondrial genome maintenance Source: Ensembl
- mitochondrion distribution Source: Ensembl
- nervous system development Source: UniProtKB-KW
- positive regulation of gene expression Source: Ensembl
- positive regulation of glucose import Source: Ensembl
- ventricular cardiac myofibril assembly Source: Ensembl
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Biological process | NeurogenesisARBA annotation, Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: MADS box transcription enhancer factor 2, polypeptide A (Myocyte enhancer factor 2A), isoform CRA_dImportedSubmitted name: Myocyte enhancer factor 2A isoform 3Imported |
Gene namesi | Name:MEF2AImported ORF Names:hCG_1993173Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000068305 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- chromatin Source: Ensembl
Keywords - Cellular componenti
NucleusARBA annotationInteractioni
GO - Molecular functioni
- DNA-binding transcription factor binding Source: Ensembl
- protein dimerization activity Source: InterPro
- protein kinase binding Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 61 | MADS-boxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 171 – 227 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 241 – 268 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 395 – 505 | DisorderedSequence analysisAdd BLAST | 111 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 426 – 446 | Pro residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 448 – 464 | Polar residuesSequence analysisAdd BLAST | 17 |
Phylogenomic databases
OMAi | MNTQRIS |
OrthoDBi | 729387at2759 |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR022102, HJURP_C IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF12347, HJURP_C, 1 hit PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
A0A0S2Z4N0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
SNKLFQYAST DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCESPD
110 120 130 140 150
ADDYFEHSPL SEDRFSKLNE DSDFIFKRGP PGLPPQNFSM SVTVPVTSPN
160 170 180 190 200
ALSYTNPGSS LVSPSLAASS TLTDSSMLSP PQTTLHRNVS PGAPQRPPST
210 220 230 240 250
GNAGGMLSTT DLTVPNGAGS SPVGNGFVNS RASPNLIGAT GANSLGKVMP
260 270 280 290 300
TKSPPPPGGG NLGMNSRKPD LRVVIPPSSK GMMPPLSEEE ELELNTQRIS
310 320 330 340 350
SSQATQPLAT PVVSVTTPSL PPQGLVYSAM PTAYNTDYSL TSADLSALQG
360 370 380 390 400
FNSPGMLSLG QVSAWQQHHL GQAALSSLVA GGQLSQGSNL SINTNQNISI
410 420 430 440 450
KSEPISPPRD RMTPSGFQQQ QQQQQQQQPP PPPQPQPQPP QPQPRQEMGR
460 470 480 490 500
SPVDSLSSSS SSYDGSDRED PRGDFHSPIV LGRPPNTEDR ESPSVKRMRM
DAWVT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 505 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178183 mRNA Translation: ALQ33641.1 CH471101 Genomic DNA Translation: EAX02252.1 |
RefSeqi | NP_001124398.1, NM_001130926.2 NP_001124399.1, NM_001130927.2 NP_001124400.1, NM_001130928.2 NP_001165365.1, NM_001171894.2 NP_001306135.1, NM_001319206.1 NP_005578.2, NM_005587.3 XP_011519885.1, XM_011521583.2 |
Genome annotation databases
GeneIDi | 4205 |
KEGGi | hsa:4205 |
MANE-Selecti | ENST00000557942.6; ENSP00000453095.1; NM_001319206.4; NP_001306135.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178183 mRNA Translation: ALQ33641.1 CH471101 Genomic DNA Translation: EAX02252.1 |
RefSeqi | NP_001124398.1, NM_001130926.2 NP_001124399.1, NM_001130927.2 NP_001124400.1, NM_001130928.2 NP_001165365.1, NM_001171894.2 NP_001306135.1, NM_001319206.1 NP_005578.2, NM_005587.3 XP_011519885.1, XM_011521583.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3854, 1066 antibodies from 43 providers |
DNASUi | 4205 |
Genome annotation databases
GeneIDi | 4205 |
KEGGi | hsa:4205 |
MANE-Selecti | ENST00000557942.6; ENSP00000453095.1; NM_001319206.4; NP_001306135.1 |
Organism-specific databases
CTDi | 4205 |
VEuPathDBi | HostDB:ENSG00000068305 |
Phylogenomic databases
OMAi | MNTQRIS |
OrthoDBi | 729387at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4205, 10 hits in 1104 CRISPR screens |
ChiTaRSi | MEF2A, human |
GenomeRNAii | 4205 |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR022102, HJURP_C IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF12347, HJURP_C, 1 hit PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0S2Z4N0_HUMAN | |
Accessioni | A0A0S2Z4N0Primary (citable) accession number: A0A0S2Z4N0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | May 25, 2022 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |