UniProtKB - A0A0S2Z4G7 (A0A0S2Z4G7_HUMAN)
Protein
Nucleophosmin
Gene
NPM1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- nucleic acid binding Source: InterPro
Keywordsi
Molecular function | ChaperoneARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: NucleophosminARBA annotation |
Gene namesi | Name:NPM1Imported ORF Names:hCG_1979311Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-KW
Keywords - Cellular componenti
NucleusARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 117 | NucleoplasminInterPro annotationAdd BLAST | 100 | |
Domaini | 216 – 264 | NPM1-CInterPro annotationAdd BLAST | 49 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 120 – 222 | DisorderedSequence analysisAdd BLAST | 103 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 162 – 186 | AcidicSequence analysisAdd BLAST | 25 | |
Compositional biasi | 187 – 207 | PolyampholyteSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the nucleoplasmin family.ARBA annotation
Family and domain databases
Gene3Di | 1.10.10.2100, 1 hit |
InterProi | View protein in InterPro IPR032569, NPM1_C IPR038101, NPM1_C_sf IPR004301, Nucleoplasmin IPR024057, Nucleoplasmin_core_dom IPR036824, Nucleoplasmin_core_dom_sf |
PANTHERi | PTHR22747, PTHR22747, 1 hit |
Pfami | View protein in Pfam PF16276, NPM1-C, 1 hit PF03066, Nucleoplasmin, 1 hit |
SUPFAMi | SSF69203, SSF69203, 1 hit |
i Sequence
Sequence statusi: Fragment.
A0A0S2Z4G7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG
60 70 80 90 100
AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL
110 120 130 140 150
RLKCGSGPVH ISGQHLVAVE EDAESEDEEE EDVKLLSISG KRSAPGGGSK
160 170 180 190 200
VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD FDDEEAEEKA PVKKGQESFK
210 220 230 240 250
KQEKTPKTPK GPSSVEDIKA KMQASIEKGG SLPKVEAKFI NYVKNCFRMT
260
DQEAIQDLWQ WRKSL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 265 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178236 mRNA Translation: ALQ33694.1 CH471062 Genomic DNA Translation: EAW61449.1 |
RefSeqi | NP_954654.1, NM_199185.3 |
Genome annotation databases
GeneIDi | 4869 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178236 mRNA Translation: ALQ33694.1 CH471062 Genomic DNA Translation: EAW61449.1 |
RefSeqi | NP_954654.1, NM_199185.3 |
3D structure databases
SMRi | A0A0S2Z4G7 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 1828, 1222 antibodies |
Genome annotation databases
GeneIDi | 4869 |
Organism-specific databases
CTDi | 4869 |
Miscellaneous databases
BioGRID-ORCSi | 4869, 510 hits in 859 CRISPR screens |
ChiTaRSi | NPM1, human |
GenomeRNAii | 4869 |
Gene expression databases
ExpressionAtlasi | A0A0S2Z4G7, baseline and differential |
Family and domain databases
Gene3Di | 1.10.10.2100, 1 hit |
InterProi | View protein in InterPro IPR032569, NPM1_C IPR038101, NPM1_C_sf IPR004301, Nucleoplasmin IPR024057, Nucleoplasmin_core_dom IPR036824, Nucleoplasmin_core_dom_sf |
PANTHERi | PTHR22747, PTHR22747, 1 hit |
Pfami | View protein in Pfam PF16276, NPM1-C, 1 hit PF03066, Nucleoplasmin, 1 hit |
SUPFAMi | SSF69203, SSF69203, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0S2Z4G7_HUMAN | |
Accessioni | A0A0S2Z4G7Primary (citable) accession number: A0A0S2Z4G7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | February 10, 2021 | |
This is version 37 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |