STK11

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
LRR domain binding Source: Ensembl
protein kinase activator activity Source: Ensembl
protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processⁱ

axonogenesis Source: Ensembl
canonical Wnt signaling pathway Source: Ensembl
cellular response to DNA damage stimulus Source: Ensembl
cellular response to UV-B Source: Ensembl
dendrite extension Source: Ensembl
establishment of cell polarity Source: Ensembl
glucose homeostasis Source: Ensembl
Golgi localization Source: Ensembl
negative regulation of cell growth Source: Ensembl
negative regulation of cold-induced thermogenesis Source: Ensembl
negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
positive regulation of axonogenesis Source: Ensembl
positive regulation of protein localization to nucleus Source: Ensembl
positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
positive thymic T cell selection Source: Ensembl
protein autophosphorylation Source: Ensembl
regulation of dendrite morphogenesis Source: Ensembl
regulation of protein kinase B signaling Source: Ensembl
regulation of Wnt signaling pathway Source: Ensembl
response to ionizing radiation Source: Ensembl
T cell receptor signaling pathway Source: Ensembl
tissue homeostasis Source: Ensembl
vasculature development Source: Ensembl

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Serine/threonine kinase 11 isoform 1Imported
Gene namesⁱ	Name:STK11Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	A0A0S2Z4D1

PRIDEⁱ

A0A0S2Z4D1

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	A0A0S2Z4D1 baseline and differential

ExpressionAtlasⁱ

A0A0S2Z4D1 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

LRR domain binding Source: Ensembl

Complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	A0A0S2Z4D1
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	49 – 309	Protein kinaseInterPro annotationAdd BLAST		261

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	312 – 331	DisorderedSequence analysisAdd BLAST		20
Regionⁱ	397 – 433	DisorderedSequence analysisAdd BLAST		37

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K07298
OMAⁱ	KNIKMVG
Database of Orthologous Groups More...OrthoDBⁱ	856506at2759
PhylomeDBⁱ	A0A0S2Z4D1

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14119 STKc_LKB1, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR039154 LKB1_c IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragment.

A0A0S2Z4D1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEVVDPQQLG MFTEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL 
        60         70         80         90        100
MGDLLGEGSY GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ 
       110        120        130        140        150
LLRRLRHKNV IQLVDVLYNE EKQKMYMVME YCVCGMQEML DSVPEKRFPV 
       160        170        180        190        200
CQAHGYFCQL IDGLEYLHSQ GIVHKDIKPG NLLLTTGGTL KISDLGVAEA 
       210        220        230        240        250
LHPFAADDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS AGVTLYNITT 
       260        270        280        290        300
GLYPFEGDNI YKLFENIGKG SYAIPGDCGP PLSDLLKGML EYEPAKRFSI 
       310        320        330        340        350
RQIRQHSWFR KKHPPAEAPV PIPPSPDTKD RWRSMTVVPY LEDLHGADED 
       360        370        380        390        400
EDLFDIEDDI IYTQDFTVPG QVPEEEASHN GQRRGLPKAV CMNGTEAAQL 
       410        420        430 
STKSRAEGRA PNPARKACSA SSKIRRLSAC KQQ

Length:433

Mass (Da):48,636

Last modified:February 17, 2016 - v1

Checksum:ⁱ6DF4C37AB7A89569

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	433	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	KU178339 mRNA Translation: ALQ33797.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000446.1, NM_000455.4

Genome annotation databases

GeneIDⁱ	6794
KEGGⁱ	hsa:6794

Protein	Similar proteins		Species	Score	Length	Source
A0A0S2Z4D1	Serine/threonine-protein kinase STK11	)	HUMAN		433	UniRef100_Q15831
STK11 [amino acids 371-433] (Fragment)		HUMAN		63

Protein	Similar proteins		Species	Score	Length	Source
A0A0S2Z4D1	Serine/threonine-protein kinase STK11	)	HUMAN		433	UniRef90_Q15831
Serine/threonine-protein kinase STK11		PIG		496
Serine/threonine kinase 11		BOVIN		435
Serine/threonine kinase 11		SAIBB		433
Uncharacterized protein		PANPA		433
+46

Protein	Similar proteins		Species	Score	Length	Source
A0A0S2Z4D1	Serine/threonine-protein kinase STK11	)	HUMAN		433	UniRef50_Q15831
Serine/threonine-protein kinase STK11		CHICK		440
Serine/threonine-protein kinase STK11		PIG		496
Serine/threonine kinase 11		BOVIN		435
Serine/threonine kinase 11		CALJA		433
+404

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	KU178339 mRNA Translation: ALQ33797.1
RefSeqⁱ	NP_000446.1, NM_000455.4

3D structure databases

SMRⁱ	A0A0S2Z4D1
ModBaseⁱ	Search...

Proteomic databases

PRIDEⁱ	A0A0S2Z4D1

PRIDEⁱ

A0A0S2Z4D1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	6794
KEGGⁱ	hsa:6794

Organism-specific databases

CTDⁱ	6794

CTDⁱ

6794

Phylogenomic databases

KOⁱ	K07298
OMAⁱ	KNIKMVG
OrthoDBⁱ	856506at2759
PhylomeDBⁱ	A0A0S2Z4D1

Miscellaneous databases

ChiTaRSⁱ	STK11 human
GenomeRNAiⁱ	6794

Gene expression databases

ExpressionAtlasⁱ	A0A0S2Z4D1 baseline and differential

ExpressionAtlasⁱ

A0A0S2Z4D1 baseline and differential

Family and domain databases

CDDⁱ	cd14119 STKc_LKB1, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR039154 LKB1_c IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A0S2Z4D1_HUMAN
Accessionⁱ	A0A0S2Z4D1Primary (citable) accession number: A0A0S2Z4D1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 17, 2016
	Last sequence update:	February 17, 2016
	Last modified:	June 5, 2019
	This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A0A0S2Z4D1 (A0A0S2Z4D1_HUMAN)

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Serine/threonine kinase 11 isoform 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ