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UniProtKB - A0A0S2Z4D1 (A0A0S2Z4D1_HUMAN)
Protein
Non-specific serine/threonine protein kinase
Gene
STK11
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 78 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- LRR domain binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- protein-containing complex binding Source: Ensembl
- protein kinase activator activity Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein serine kinase activity Source: RHEA
GO - Biological processi
- axonogenesis Source: Ensembl
- canonical Wnt signaling pathway Source: Ensembl
- cellular response to DNA damage stimulus Source: Ensembl
- cellular response to UV-B Source: Ensembl
- dendrite extension Source: Ensembl
- establishment of cell polarity Source: Ensembl
- glucose homeostasis Source: Ensembl
- Golgi localization Source: Ensembl
- negative regulation of cell growth Source: Ensembl
- negative regulation of cold-induced thermogenesis Source: Ensembl
- negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
- positive regulation of axonogenesis Source: Ensembl
- positive regulation of gluconeogenesis Source: Ensembl
- positive regulation of protein localization to nucleus Source: Ensembl
- positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- positive regulation of vesicle transport along microtubule Source: Ensembl
- positive thymic T cell selection Source: Ensembl
- protein autophosphorylation Source: Ensembl
- regulation of dendrite morphogenesis Source: Ensembl
- regulation of protein kinase B signaling Source: Ensembl
- regulation of Wnt signaling pathway Source: Ensembl
- response to activity Source: Ensembl
- response to glucagon Source: Ensembl
- response to ionizing radiation Source: Ensembl
- response to lipid Source: Ensembl
- response to thyroid hormone Source: Ensembl
- T cell receptor signaling pathway Source: Ensembl
- tissue homeostasis Source: Ensembl
- vasculature development Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, MagnesiumARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:STK11Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000118046 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- membrane Source: Ensembl
- protein-containing complex Source: Ensembl
- Z disc Source: Ensembl
Keywords - Cellular componenti
CytoplasmARBA annotationInteractioni
GO - Molecular functioni
- LRR domain binding Source: Ensembl
Chemistry databases
BindingDBi | A0A0S2Z4D1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 309 | Protein kinaseInterPro annotationAdd BLAST | 261 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 312 – 331 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 397 – 433 | DisorderedSequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.ARBA annotation
Phylogenomic databases
OMAi | AYHYGSE |
OrthoDBi | 856506at2759 |
PhylomeDBi | A0A0S2Z4D1 |
Family and domain databases
CDDi | cd14119, STKc_LKB1, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR039154, LKB1_c IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Fragment.
A0A0S2Z4D1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVVDPQQLG MFTEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL
60 70 80 90 100
MGDLLGEGSY GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ
110 120 130 140 150
LLRRLRHKNV IQLVDVLYNE EKQKMYMVME YCVCGMQEML DSVPEKRFPV
160 170 180 190 200
CQAHGYFCQL IDGLEYLHSQ GIVHKDIKPG NLLLTTGGTL KISDLGVAEA
210 220 230 240 250
LHPFAADDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS AGVTLYNITT
260 270 280 290 300
GLYPFEGDNI YKLFENIGKG SYAIPGDCGP PLSDLLKGML EYEPAKRFSI
310 320 330 340 350
RQIRQHSWFR KKHPPAEAPV PIPPSPDTKD RWRSMTVVPY LEDLHGADED
360 370 380 390 400
EDLFDIEDDI IYTQDFTVPG QVPEEEASHN GQRRGLPKAV CMNGTEAAQL
410 420 430
STKSRAEGRA PNPARKACSA SSKIRRLSAC KQQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 433 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178339 mRNA Translation: ALQ33797.1 |
RefSeqi | NP_000446.1, NM_000455.4 |
Genome annotation databases
GeneIDi | 6794 |
KEGGi | hsa:6794 |
MANE-Selecti | ENST00000326873.12; ENSP00000324856.6; NM_000455.5; NP_000446.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178339 mRNA Translation: ALQ33797.1 |
RefSeqi | NP_000446.1, NM_000455.4 |
3D structure databases
SMRi | A0A0S2Z4D1 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A0S2Z4D1 |
Protocols and materials databases
Antibodypediai | 2048, 1350 antibodies from 44 providers |
DNASUi | 6794 |
Genome annotation databases
GeneIDi | 6794 |
KEGGi | hsa:6794 |
MANE-Selecti | ENST00000326873.12; ENSP00000324856.6; NM_000455.5; NP_000446.1 |
Organism-specific databases
CTDi | 6794 |
VEuPathDBi | HostDB:ENSG00000118046 |
Phylogenomic databases
OMAi | AYHYGSE |
OrthoDBi | 856506at2759 |
PhylomeDBi | A0A0S2Z4D1 |
Miscellaneous databases
BioGRID-ORCSi | 6794, 137 hits in 1094 CRISPR screens |
ChiTaRSi | STK11, human |
GenomeRNAii | 6794 |
Gene expression databases
ExpressionAtlasi | A0A0S2Z4D1, baseline and differential |
Family and domain databases
CDDi | cd14119, STKc_LKB1, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR039154, LKB1_c IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0S2Z4D1_HUMAN | |
Accessioni | A0A0S2Z4D1Primary (citable) accession number: A0A0S2Z4D1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | January 19, 2022 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |