Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
1 to 25 of 508  Show
  1. 1
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 1021 other entries.

  2. 2
    "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis."
    Larramendy M.L., Niini T., Elonen E., Nagy B., Ollila J., Vihinen M., Knuutila S.
    Haematologica 87:569-577(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: overexpressed in acute myeloid leukemia while translocations associated with this gene are absent.
    Source: GeneRIF:4869.

    This publication is mapped to 97 other entries.

  3. 3
    "A major nucleolar protein B23 as a marker of proliferation activity of human peripheral lymphocytes."
    Dergunova N., Bulycheva T.I., Artemenko E.G., Shpakova A.P., Pegova A.N., Gemjian E.G., Dudnik O.A., Zatsepina O.V., Malashenko O.S.
    Immunol. Lett. 83:67-72(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: marker of proliferation activity of human peripheral lymphocytes.
    Source: GeneRIF:4869.

    This publication is mapped to 7 other entries.

  4. 4
    "Nucleophosmin regulates the stability and transcriptional activity of p53."
    Colombo E., Marine J.C., Danovi D., Falini B., Pelicci P.G.
    Nat. Cell Biol. 4:529-533(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: NPM is a crucial regulator of p53.
    Source: GeneRIF:4869.

    This publication is mapped to 191 other entries.

  5. 5
    "UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNA."
    Wu M.H., Yung B.Y.
    J. Biol. Chem. 277:48234-48240(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: involvement of NPM/B23 in the acute response of mammalian cells to environmental stress such as UV rays.
    Source: GeneRIF:4869.

    This publication is mapped to 17 other entries.

  6. 6
    "Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR."
    Pang Q., Christianson T.A., Koretsky T., Carlson H., David L., Keeble W., Faulkner G.R., Speckhart A., Bagby G.C.
    J. Biol. Chem. 278:41709-41717(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: overexpression of NPM suppressed PKR activity enhanced protein synthesis and inhibited apoptosis. Fanconi anemia lymphoblasts expressed low levels of NPM which correlated with high ground-state activation of PKR and hypersensitivity to apoptotic cues.
    Source: GeneRIF:4869.

    This publication is cited by 3 and mapped to 21 other entries.

  7. 7
    "Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia."
    Arber D.A., Chang K.L., Lyda M.H., Bedell V., Spielberger R., Slovak M.L.
    Hum. Pathol. 34:809-813(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: These findings suggest that an NPM/MLF1 fusion is the primary molecular abnormality in t(3;5) MDS and AML with multilineage dysplasia and that cases with NPM/MLF1 may be clinically distinct from other MDS-associated disease.
    Source: GeneRIF:4869.

    This publication is mapped to 16 other entries.

  8. 8
    "Unique conformation of cancer autoantigen B23 in hepatoma: a mechanism for specificity in the autoimmune response."
    Ulanet D.B., Torbenson M., Dang C.V., Casciola-Rosen L., Rosen A.
    Proc. Natl. Acad. Sci. U.S.A. 100:12361-12366(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: unique B23 conformation in hepatoma.
    Source: GeneRIF:4869.

    This publication is mapped to 7 other entries.

  9. 9
    "Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity."
    Cussac D., Greenland C., Roche S., Bai R.Y., Duyster J., Morris S.W., Delsol G., Allouche M., Payrastre B.
    Blood 103:1464-1471(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Src-kinases particularly pp60(c-src) associate with and are activated by NPM-ALK expression in various cells and in cell lines established from patients with large cell lymphoma.
    Source: GeneRIF:4869.

    This publication is mapped to 37 other entries.

  10. 10
    "Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation."
    Itahana K., Bhat K.P., Jin A., Itahana Y., Hawke D., Kobayashi R., Zhang Y.
    Mol. Cell 12:1151-1164(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: Results reveal a molecular mechanism of ARF in regulating ribosome biogenesis and cell proliferation via inhibiting B23.
    Source: GeneRIF:4869.

    This publication is mapped to 7 other entries.

  11. 11
    "Bcl-XL down-regulation suppresses the tumorigenic potential of NPM/ALK in vitro and in vivo."
    Coluccia A.M., Perego S., Cleris L., Gunby R.H., Passoni L., Marchesi E., Formelli F., Gambacorti-Passerini C.
    Blood 103:2787-2794(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: NPM/ALK-mediated induction of Bcl-XL.
    Source: GeneRIF:4869.

    This publication is mapped to 41 other entries.

  12. 12
    "Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes."
    Ulanet D.B., Flavahan N.A., Casciola-Rosen L., Rosen A.
    Arthritis Rheum. 50:233-241(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: cleavage of B23 by granzyme b in intact vascular smooth muscle cells is dependent upon both cell type and phenotype.
    Source: GeneRIF:4869.

    This publication is mapped to 7 other entries.

  13. 13
    "Nucleophosmin sets a threshold for p53 response to UV radiation."
    Maiguel D.A., Jones L., Chakravarty D., Yang C., Carrier F.
    Mol. Cell. Biol. 24:3703-3711(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Interaction.
    Annotation: These data suggest that nucleophosmin is an early responder to DNA damage that prevents premature activation of p53.
    Source: GeneRIF:4869.

    This publication is mapped to 191 other entries.

  14. 14
    "Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 gene."
    Dhar S.K., Lynn B.C., Daosukho C., St Clair D.K.
    J. Biol. Chem. 279:28209-28219(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: nucleophosmin is an NF-kappaB co-activator for the induction of the human SOD2 gene.
    Source: GeneRIF:4869.

    This publication is mapped to 30 other entries.

  15. 15
    "Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase."
    Sato K., Hayami R., Wu W., Nishikawa T., Nishikawa H., Okuda Y., Ogata H., Fukuda M., Ohta T.
    J. Biol. Chem. 279:30919-30922(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: BRCA1-BARD1 catalyzes the polyubiquitination of nucleolar phosphoprotein nucleophosmin/B23.
    Source: GeneRIF:4869.

    This publication is mapped to 19 other entries.

  16. 16
    "B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1."
    Zhang H., Shi X., Paddon H., Hampong M., Dai W., Pelech S.
    J. Biol. Chem. 279:35726-35734(2004) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: identification of Ser-4 in B23 as a major physiological substrate of Polo-like kinase 1.
    Source: GeneRIF:4869.

    This publication is mapped to 12 other entries.

  17. 17
    "Hypoxia-induced nucleophosmin protects cell death through inhibition of p53."
    Li J., Zhang X., Sejas D.P., Bagby G.C., Pang Q.
    J. Biol. Chem. 279:41275-41279(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: NPM inhibits hypoxia-induced p53 phosphorylation at Ser-15 and interacts with p53 in hypoxic cells; hypoxia-driven cancer progression may require increased expression of NPM to suppress p53 activation and maintain cell survival.
    Source: GeneRIF:4869.

    This publication is mapped to 191 other entries.

  18. 18
    "Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis."
    Lee H.Z., Wu C.H., Chang S.P.
    Int. J. Cancer 113:971-976(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Aloe-emodin caused increase in the amount of proform and fragment of nucleophosmin in cytoplasm may be one of the important events for aloe-emodin-induced H460 cell apoptosis pf mpm-small cell lung cancer.
    Source: GeneRIF:4869.

    This publication is mapped to 7 other entries.

  19. 19
    "c-Myc-mediated expression of nucleophosmin/B23 decreases during retinoic acid-induced differentiation of human leukemia HL-60 cells."
    Yung B.Y.
    FEBS Lett. 578:211-216(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: c-Myc-mediated expression of NPM decreases during retinoic acid-induced differentiation of HL-60 cells.
    Source: GeneRIF:4869.

    This publication is mapped to 7 other entries.

  20. 20
    "B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrest."
    Gao H., Jin S., Song Y., Fu M., Wang M., Liu Z., Wu M., Zhan Q.
    J. Biol. Chem. 280:10988-10996(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: a novel association of B23 and Gadd45a and implicate B23 as an important regulator in Gadd45a nuclear import.
    Source: GeneRIF:4869.

    This publication is mapped to 9 other entries.

  21. 21
    Category: Function.
    Annotation: Cytoplasmic NPM is a characteristic feature of a large subgroup of patients with AML who have a normal karyotype NPM gene mutations and responsiveness to induction chemotherapy.
    Source: GeneRIF:4869.

    This publication is mapped to 6 other entries.

  22. 22
    "Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2."
    Hayami R., Sato K., Wu W., Nishikawa T., Hiroi J., Ohtani-Kaneko R., Fukuda M., Ohta T.
    Cancer Res. 65:6-10(2005) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: CDK2-BRCA1-NPM pathway coordinately functions in cell growth and tumor progression pathways.
    Source: GeneRIF:4869.

    This publication is mapped to 25 other entries.

  23. 23
    "Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function."
    Korgaonkar C., Hagen J., Tompkins V., Frazier A.A., Allamargot C., Quelle F.W., Quelle D.E.
    Mol. Cell. Biol. 25:1258-1271(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location, Interaction.
    Annotation: NPM inhibits ARF's p53-dependent activity by targeting it to nucleoli and impairing ARF-Mdm2 association.
    Source: GeneRIF:4869.

    This publication is mapped to 7 other entries.

  24. 24
    "Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance."
    Alcalay M., Tiacci E., Bergomas R., Bigerna B., Venturini E., Minardi S.P., Meani N., Diverio D., Bernard L., Tizzoni L., Volorio S., Luzi L., Colombo E., Lo Coco F., Mecucci C., Falini B., Pelicci P.G.
    Blood 106:899-902(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: The molecular signature of cytoplasmic NPM+ AML includes up-regulation of several genes putatively involved in the maintenance of a stem-cell phenotype suggesting that cytoplasmic NPM+ AML may derive from a multipotent hematopoietic progenitor.
    Source: GeneRIF:4869.

    This publication is mapped to 7 other entries.

  25. 25
    "Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype."
    Cazzaniga G., Dell'Oro M.G., Mecucci C., Giarin E., Masetti R., Rossi V., Locatelli F., Martelli M.F., Basso G., Pession A., Biondi A., Falini B.
    Blood 106:1419-1422(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: base sequences are given for NPM1 mutated childhood AML patients; consistent deletion/insertion features are presented; Observational study of genotype prevalence. (HuGE Navigator).
    Source: GeneRIF:4869.

    This publication is mapped to 7 other entries.

1 to 25 of 508  Show
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again