UniProtKB - A0A0S2Z447 (A0A0S2Z447_HUMAN)
Protein
Submitted name:
Parkinson protein 2 E3 ubiquitin protein ligase isoform 3
Gene
PARK2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin-protein transferase activity Source: InterPro
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Parkinson protein 2 E3 ubiquitin protein ligase isoform 3Imported |
Gene namesi | Name:PARK2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytosol
- cytosol Source: InterPro
Mitochondrion
- mitochondrion Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 72 | Ubiquitin-likeInterPro annotationAdd BLAST | 72 | |
Domaini | 233 – 367 | RING-typeInterPro annotationAdd BLAST | 135 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 77 – 99 | DisorderedSequence analysisAdd BLAST | 23 |
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerARBA annotationFamily and domain databases
InterProi | View protein in InterPro IPR003977, Parkin IPR041565, Parkin_Znf-RING IPR044066, TRIAD_supradom IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR041170, Znf-RING_14 |
Pfami | View protein in Pfam PF00240, ubiquitin, 1 hit PF17976, zf-RING_12, 1 hit PF17978, zf-RING_14, 1 hit |
PIRSFi | PIRSF037880, Parkin, 1 hit |
PRINTSi | PR01475, PARKIN |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS51873, TRIAD, 1 hit PS50053, UBIQUITIN_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
A0A0S2Z447-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL
60 70 80 90 100
RNDWTVQNCD LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ
110 120 130 140 150
SLTRVDLSSS VLPGDSVGLA VILHTDSRKD SPPAGSPGRS IYNSFYVYCK
160 170 180 190 200
GPCQRVQPGK LRVQCSTCRQ ATLTLTQGPS CWDDVLIPNR MSGECQSPHC
210 220 230 240 250
PGTSAEFFFK CGAHPTSDKE TSVALHLIAT NSRNITCITC TDVRSPVLVF
260 270 280 290 300
QCNSRHVICL DCFHLYCVTR LNDRQFVHDP QLGYSLPCVA GCPNSLIKEL
310 320 330 340 350
HHFRILGEEQ YNRYQQYGAE ECVLQMGGVL CPRPGCGAGL LPEPDQRKVT
360
CEGGNGLGCG YGQRRTK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 367 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178242 mRNA Translation: ALQ33700.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178242 mRNA Translation: ALQ33700.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A0S2Z447 |
Miscellaneous databases
ChiTaRSi | PARK2, human |
Family and domain databases
InterProi | View protein in InterPro IPR003977, Parkin IPR041565, Parkin_Znf-RING IPR044066, TRIAD_supradom IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR041170, Znf-RING_14 |
Pfami | View protein in Pfam PF00240, ubiquitin, 1 hit PF17976, zf-RING_12, 1 hit PF17978, zf-RING_14, 1 hit |
PIRSFi | PIRSF037880, Parkin, 1 hit |
PRINTSi | PR01475, PARKIN |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS51873, TRIAD, 1 hit PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0S2Z447_HUMAN | |
Accessioni | A0A0S2Z447Primary (citable) accession number: A0A0S2Z447 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | February 10, 2021 | |
This is version 18 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |