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Protein

Galactose-1-phosphate uridylyltransferase

Gene

GALT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei186Tele-UMP-histidine intermediateUniRule annotation1
Metal bindingi202IronUniRule annotation1
Metal bindingi301IronUniRule annotation1
Metal bindingi319IronUniRule annotation1
Metal bindingi321IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationImported, Transferase
Biological processCarbohydrate metabolism, Galactose metabolismUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00214

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferaseUniRule annotation (EC:2.7.7.12UniRule annotation)
Gene namesi
Name:GALTImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PRIDEiA0A0S2Z3Y7

Expressioni

Gene expression databases

ExpressionAtlasiA0A0S2Z3Y7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0S2Z3Y7
SMRiA0A0S2Z3Y7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 196GalP_UDP_transfInterPro annotationAdd BLAST173
Domaini203 – 368GalP_UDP_tr_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.UniRule annotation

Phylogenomic databases

KOiK00965
OMAiHAIYYPP
PhylomeDBiA0A0S2Z3Y7

Family and domain databases

CDDicd00608 GalT, 1 hit
Gene3Di3.30.428.10, 2 hits
InterProiView protein in InterPro
IPR001937 GalP_UDPtransf1
IPR019779 GalP_UDPtransf1_His-AS
IPR005850 GalP_Utransf_C
IPR005849 GalP_Utransf_N
IPR036265 HIT-like_sf
PANTHERiPTHR11943 PTHR11943, 1 hit
PfamiView protein in Pfam
PF02744 GalP_UDP_tr_C, 1 hit
PF01087 GalP_UDP_transf, 1 hit
PIRSFiPIRSF000808 GalT, 1 hit
SUPFAMiSSF54197 SSF54197, 2 hits
TIGRFAMsiTIGR00209 galT_1, 1 hit
PROSITEiView protein in PROSITE
PS00117 GAL_P_UDP_TRANSF_I, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A0S2Z3Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSGTDPQQ RQQASEADAA AATFRANDHQ HIRYNPLQDE WVLVSAHRMK
60 70 80 90 100
RPWQGQVEPQ LLKTVPRHDP LNPLCPGAIR ANGEVNPQYD STFLFDNDFP
110 120 130 140 150
ALQPDAPSPG PSDHPLFQAK SARGVCKVMC FHPWSDVTLP LMSVPEIRAV
160 170 180 190 200
VDAWASVTEE LGAQYPWVQI FENKGAMMGC SNPHPHCQVW ASSFLPDIAQ
210 220 230 240 250
REERSQQAYK SQHGEPLLME YSRQELLRKE RLVLTSEHWL VLVPFWATWP
260 270 280 290 300
YQTLLLPRRH VRRLPELTPA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW
310 320 330 340 350
HGAPTGSEAG ANWNHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT
360 370
PEQAAERLRA LPEVHYHLGQ KDRETATIA
Length:379
Mass (Da):43,363
Last modified:February 17, 2016 - v1
Checksum:i99945FF99C4F0066
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei379Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU178089 mRNA Translation: ALQ33547.1
RefSeqiNP_000146.2, NM_000155.3
UniGeneiHs.522090

Genome annotation databases

GeneIDi2592
KEGGihsa:2592

Similar proteinsi

Entry informationi

Entry nameiA0A0S2Z3Y7_HUMAN
AccessioniPrimary (citable) accession number: A0A0S2Z3Y7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: July 18, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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