UniProtKB - A0A0S2Z3Y7 (A0A0S2Z3Y7_HUMAN)
Protein
Galactose-1-phosphate uridylyltransferase
Gene
GALT
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- α-D-galactose 1-phosphate + UDP-α-D-glucose = α-D-glucose 1-phosphate + UDP-α-D-galactosePROSITE-ProRule annotationARBA annotationEC:2.7.7.12PROSITE-ProRule annotationARBA annotation
Cofactori
Protein has several cofactor binding sites:- Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation
- Zn2+ARBA annotation
: galactose metabolism Pathwayi
This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.UniRule annotationARBA annotationView all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 81 | UDP-alpha-D-glucose; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 173 | UDP-alpha-D-glucoseUniRule annotation | 1 | |
Metal bindingi | 184 | ZincPROSITE-ProRule annotation | 1 | |
Active sitei | 186 | Tele-UMP-histidine intermediateUniRule annotation | 1 | |
Binding sitei | 188 | UDP-alpha-D-glucoseUniRule annotation | 1 | |
Metal bindingi | 202 | IronUniRule annotation | 1 | |
Metal bindingi | 301 | IronUniRule annotation | 1 | |
Metal bindingi | 319 | IronUniRule annotation | 1 | |
Metal bindingi | 321 | IronUniRule annotation | 1 | |
Binding sitei | 346 | UDP-alpha-D-glucoseUniRule annotation | 1 |
GO - Molecular functioni
- UDP-glucose:hexose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- galactose catabolic process via UDP-galactose Source: InterPro
- UDP-glucose catabolic process Source: Ensembl
Keywordsi
Molecular function | NucleotidyltransferaseUniRule annotationImportedARBA annotation, Transferase |
Biological process | Carbohydrate metabolism, Galactose metabolismUniRule annotationARBA annotation |
Ligand | IronUniRule annotation, Metal-bindingUniRule annotationARBA annotation, ZincARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00214 |
Names & Taxonomyi
Protein namesi | Recommended name: Galactose-1-phosphate uridylyltransferaseUniRule annotation (EC:2.7.7.12UniRule annotation) |
Gene namesi | Name:GALTImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 196 | GalP_UDP_transfInterPro annotationAdd BLAST | 173 | |
Domaini | 203 – 368 | GalP_UDP_tr_CInterPro annotationAdd BLAST | 166 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 48 – 51 | UDP-alpha-D-glucose binding; shared with dimeric partnerUniRule annotation | 4 | |
Regioni | 97 – 98 | UDP-alpha-D-glucose bindingUniRule annotation | 2 | |
Regioni | 179 – 181 | UDP-alpha-D-glucose bindingUniRule annotation | 3 | |
Regioni | 334 – 335 | UDP-alpha-D-glucose binding; shared with dimeric partnerUniRule annotation | 2 | |
Regioni | 339 – 340 | UDP-alpha-D-glucose binding; shared with dimeric partnerUniRule annotation | 2 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | PolarSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.UniRule annotationARBA annotation
Phylogenomic databases
OMAi | HAIYYPP |
OrthoDBi | 1135699at2759 |
PhylomeDBi | A0A0S2Z3Y7 |
Family and domain databases
CDDi | cd00608, GalT, 1 hit |
Gene3Di | 3.30.428.10, 2 hits |
InterProi | View protein in InterPro IPR001937, GalP_UDPtransf1 IPR019779, GalP_UDPtransf1_His-AS IPR005850, GalP_Utransf_C IPR005849, GalP_Utransf_N IPR036265, HIT-like_sf |
PANTHERi | PTHR11943, PTHR11943, 1 hit |
Pfami | View protein in Pfam PF02744, GalP_UDP_tr_C, 1 hit PF01087, GalP_UDP_transf, 1 hit |
PIRSFi | PIRSF000808, GalT, 1 hit |
SUPFAMi | SSF54197, SSF54197, 2 hits |
TIGRFAMsi | TIGR00209, galT_1, 1 hit |
PROSITEi | View protein in PROSITE PS00117, GAL_P_UDP_TRANSF_I, 1 hit |
i Sequence
Sequence statusi: Fragment.
A0A0S2Z3Y7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRSGTDPQQ RQQASEADAA AATFRANDHQ HIRYNPLQDE WVLVSAHRMK
60 70 80 90 100
RPWQGQVEPQ LLKTVPRHDP LNPLCPGAIR ANGEVNPQYD STFLFDNDFP
110 120 130 140 150
ALQPDAPSPG PSDHPLFQAK SARGVCKVMC FHPWSDVTLP LMSVPEIRAV
160 170 180 190 200
VDAWASVTEE LGAQYPWVQI FENKGAMMGC SNPHPHCQVW ASSFLPDIAQ
210 220 230 240 250
REERSQQAYK SQHGEPLLME YSRQELLRKE RLVLTSEHWL VLVPFWATWP
260 270 280 290 300
YQTLLLPRRH VRRLPELTPA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW
310 320 330 340 350
HGAPTGSEAG ANWNHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT
360 370
PEQAAERLRA LPEVHYHLGQ KDRETATIA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 379 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178089 mRNA Translation: ALQ33547.1 |
RefSeqi | NP_000146.2, NM_000155.3 |
Genome annotation databases
GeneIDi | 2592 |
KEGGi | hsa:2592 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178089 mRNA Translation: ALQ33547.1 |
RefSeqi | NP_000146.2, NM_000155.3 |
3D structure databases
SMRi | A0A0S2Z3Y7 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 1384, 313 antibodies |
Genome annotation databases
GeneIDi | 2592 |
KEGGi | hsa:2592 |
Organism-specific databases
CTDi | 2592 |
Phylogenomic databases
OMAi | HAIYYPP |
OrthoDBi | 1135699at2759 |
PhylomeDBi | A0A0S2Z3Y7 |
Enzyme and pathway databases
UniPathwayi | UPA00214 |
Miscellaneous databases
BioGRID-ORCSi | 2592, 3 hits in 843 CRISPR screens |
ChiTaRSi | GALT, human |
GenomeRNAii | 2592 |
Gene expression databases
ExpressionAtlasi | A0A0S2Z3Y7, baseline and differential |
Family and domain databases
CDDi | cd00608, GalT, 1 hit |
Gene3Di | 3.30.428.10, 2 hits |
InterProi | View protein in InterPro IPR001937, GalP_UDPtransf1 IPR019779, GalP_UDPtransf1_His-AS IPR005850, GalP_Utransf_C IPR005849, GalP_Utransf_N IPR036265, HIT-like_sf |
PANTHERi | PTHR11943, PTHR11943, 1 hit |
Pfami | View protein in Pfam PF02744, GalP_UDP_tr_C, 1 hit PF01087, GalP_UDP_transf, 1 hit |
PIRSFi | PIRSF000808, GalT, 1 hit |
SUPFAMi | SSF54197, SSF54197, 2 hits |
TIGRFAMsi | TIGR00209, galT_1, 1 hit |
PROSITEi | View protein in PROSITE PS00117, GAL_P_UDP_TRANSF_I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0S2Z3Y7_HUMAN | |
Accessioni | A0A0S2Z3Y7Primary (citable) accession number: A0A0S2Z3Y7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | December 2, 2020 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |