UniProtKB - A0A0S2Z3Y1 (A0A0S2Z3Y1_HUMAN)
Protein
Galectin-3-binding protein
Gene
LGALS3BP
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- scavenger receptor activity Source: InterPro
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
Keywordsi
Biological process | Cell adhesionARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Galectin-3-binding proteinARBA annotationAlternative name(s): Lectin galactoside-binding soluble 3-binding proteinARBA annotation |
Gene namesi | Name:LGALS3BPImported ORF Names:hCG_1776358Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Other locations
- membrane Source: InterPro
Keywords - Cellular componenti
Extracellular matrixARBA annotation, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_5014239312 | 19 – 585 | Galectin-3-binding proteinSequence analysisAdd BLAST | 567 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 113 | PROSITE-ProRule annotation | ||
Disulfide bondi | 62 ↔ 123 | PROSITE-ProRule annotation | ||
Disulfide bondi | 93 ↔ 103 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 124 | SRCRInterPro annotationAdd BLAST | 101 | |
Domaini | 153 – 221 | BTBInterPro annotationAdd BLAST | 69 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
OMAi | NCSSLGW |
OrthoDBi | 1174057at2759 |
Family and domain databases
Gene3Di | 3.10.250.10, 1 hit |
InterProi | View protein in InterPro IPR011705, BACK IPR000210, BTB/POZ_dom IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00530, SRCR, 1 hit |
PRINTSi | PR00258, SPERACTRCPTR |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00202, SR, 1 hit |
SUPFAMi | SSF56487, SSF56487, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00420, SRCR_1, 1 hit PS50287, SRCR_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
A0A0S2Z3Y1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD
60 70 80 90 100
NLWDLTDASV VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL
110 120 130 140 150
ADCKSLGWLK SNCRHERDAG VVCTNETRST HTLDLSRELS EALGQIFDSQ
160 170 180 190 200
RGCDLSISVN VQGEDALGFC GHTVILTANL EAQALWKEPG SNVTMSVDAE
210 220 230 240 250
CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ GYCASLFAIL
260 270 280 290 300
LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP
310 320 330 340 350
TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM
360 370 380 390 400
MLPEELFELQ FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT
410 420 430 440 450
EDTYKPRIYT SPTWSAFVTD SSWSARKSQL VYQSRRGPLV KYSSDYFQAP
460 470 480 490 500
SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL VYLPTIQSCW NYGFSCSSDE
510 520 530 540 550
LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW KAAIPSALDT
560 570 580
NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 585 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178164 mRNA Translation: ALQ33622.1 CH471099 Genomic DNA Translation: EAW89546.1 |
RefSeqi | NP_005558.1, NM_005567.3 |
Genome annotation databases
GeneIDi | 3959 |
KEGGi | hsa:3959 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178164 mRNA Translation: ALQ33622.1 CH471099 Genomic DNA Translation: EAW89546.1 |
RefSeqi | NP_005558.1, NM_005567.3 |
3D structure databases
SMRi | A0A0S2Z3Y1 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 604, 392 antibodies |
Genome annotation databases
GeneIDi | 3959 |
KEGGi | hsa:3959 |
Organism-specific databases
CTDi | 3959 |
Phylogenomic databases
OMAi | NCSSLGW |
OrthoDBi | 1174057at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3959, 10 hits in 844 CRISPR screens |
ChiTaRSi | LGALS3BP, human |
GenomeRNAii | 3959 |
Gene expression databases
ExpressionAtlasi | A0A0S2Z3Y1, baseline and differential |
Family and domain databases
Gene3Di | 3.10.250.10, 1 hit |
InterProi | View protein in InterPro IPR011705, BACK IPR000210, BTB/POZ_dom IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00530, SRCR, 1 hit |
PRINTSi | PR00258, SPERACTRCPTR |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00202, SR, 1 hit |
SUPFAMi | SSF56487, SSF56487, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00420, SRCR_1, 1 hit PS50287, SRCR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0S2Z3Y1_HUMAN | |
Accessioni | A0A0S2Z3Y1Primary (citable) accession number: A0A0S2Z3Y1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | December 2, 2020 | |
This is version 39 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |