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Protein

Rab GDP dissociation inhibitor

Gene

GDI1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitorUniRule annotation
Gene namesi
Name:GDI1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiA0A0S2Z3X8

Expressioni

Gene expression databases

ExpressionAtlasiA0A0S2Z3X8 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiA0A0S2Z3X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.UniRule annotation

Phylogenomic databases

KOiK17255
OMAiEDPATHQ

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Fragment.

A0A0S2Z3X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE
60 70 80 90 100
ELYKRFQLLE GPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL
110 120 130 140 150
DFKVVEGSFV YKGGKIYKVP STETEALASN LMGMFEKRRF RKFLVFVANF
160 170 180 190 200
DENDPKTFEG VDPQTTSMRD VYRKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCLETVNRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VRKAGQVIRI
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI
360 370 380 390 400
AIASTTVETT DPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGCESQVFC
410 420 430 440
SCSYDATTHF ETTCNDIKDI YKRMAGTAFD FENMKRKQND VFGEAEQ
Length:447
Mass (Da):50,583
Last modified:February 17, 2016 - v1
Checksum:iBC283A445E50A652
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei447Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM005621 mRNA Translation: AEE61218.1
KU178091 mRNA Translation: ALQ33549.1
RefSeqiNP_001484.1, NM_001493.2
UniGeneiHs.595950
Hs.74576

Genome annotation databases

GeneIDi2664
KEGGihsa:2664

Similar proteinsi

Entry informationi

Entry nameiA0A0S2Z3X8_HUMAN
AccessioniPrimary (citable) accession number: A0A0S2Z3X8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: May 23, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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