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UniProtKB - A0A0S2Z3E6 (A0A0S2Z3E6_HUMAN)
Protein
Calpain-3
Gene
CAPN3
Organism
Homo sapiens (Human)
Status
Functioni
Calcium-regulated non-lysosomal thiol-protease.
UniRule annotationCatalytic activityi
- Broad endopeptidase activity.UniRule annotation EC:3.4.22.54
GO - Molecular functioni
- calcium-dependent cysteine-type endopeptidase activity Source: UniProtKB-UniRule
- calcium ion binding Source: UniProtKB-UniRule
GO - Biological processi
- sarcomere organization Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseUniRule annotation |
Ligand | CalciumUniRule annotation, Metal-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CAPN3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1480, CAPN3 |
VEuPathDBi | HostDB:ENSG00000092529 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationInteractioni
Subunit structurei
Homodimer.
UniRule annotationBinary interactionsi
A0A0S2Z3E6
With | #Exp. | IntAct |
---|---|---|
CEP76 [Q8TAP6] | 3 | EBI-16430532,EBI-742887 |
TFCP2 [Q12800] | 3 | EBI-16430532,EBI-717422 |
Protein-protein interaction databases
IntActi | A0A0S2Z3E6, 2 interactors |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 70 | calpain_IIIInterPro annotationAdd BLAST | 69 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000156092 |
Family and domain databases
InterProi | View protein in InterPro IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR029531, CAPN3 |
PANTHERi | PTHR10183:SF329, PTHR10183:SF329, 1 hit |
Pfami | View protein in Pfam PF01067, Calpain_III, 1 hit |
SMARTi | View protein in SMART SM00720, calpain_III, 1 hit |
SUPFAMi | SSF49758, SSF49758, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 20 potential isoforms that are computationally mapped.Show allAlign All
A0A0S2Z3E6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHGNKQHLQK DFFLYNASKA RSKTYINMRE VSQRFRLPPS EYVIVPSTYE
60 70 80
PHQEGEFILR VFSEKRNLSE EVENTISVDR PVW
Computationally mapped potential isoform sequencesi
There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP20807 | CAN3_HUMAN | Calpain-3 | CAPN3 CANP3, CANPL3, NCL1 | 821 | Annotation score: | ||
F8W8F5 | F8W8F5_HUMAN | Calpain-3 | CAPN3 | 773 | Annotation score: | ||
H3BMH1 | H3BMH1_HUMAN | Calpain-3 | CAPN3 | 255 | Annotation score: | ||
A0A669KAB9 | A0A669KAB9_HUMAN | Calpain-3 | CAPN3 | 202 | Annotation score: | ||
A0A669KB08 | A0A669KB08_HUMAN | Calpain-3 | CAPN3 | 229 | Annotation score: | ||
H3BV08 | H3BV08_HUMAN | Calpain-3 | CAPN3 | 169 | Annotation score: | ||
H3BNN7 | H3BNN7_HUMAN | Calpain-3 | CAPN3 | 110 | Annotation score: | ||
H3BS77 | H3BS77_HUMAN | Calpain-3 | CAPN3 | 191 | Annotation score: | ||
A0A669KB98 | A0A669KB98_HUMAN | Calpain-3 | CAPN3 | 144 | Annotation score: | ||
A0A669KAU6 | A0A669KAU6_HUMAN | Calpain-3 | CAPN3 | 184 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012651 Genomic DNA No translation available. KU177955 mRNA Translation: ALQ33413.1 |
Genome annotation databases
Ensembli | ENST00000673646; ENSP00000501007; ENSG00000092529 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012651 Genomic DNA No translation available. KU177955 mRNA Translation: ALQ33413.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A0A0S2Z3E6, 2 interactors |
Genome annotation databases
Ensembli | ENST00000673646; ENSP00000501007; ENSG00000092529 |
Organism-specific databases
HGNCi | HGNC:1480, CAPN3 |
OpenTargetsi | ENSG00000092529 |
VEuPathDBi | HostDB:ENSG00000092529 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156092 |
Miscellaneous databases
ChiTaRSi | CAPN3, human |
Family and domain databases
InterProi | View protein in InterPro IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR029531, CAPN3 |
PANTHERi | PTHR10183:SF329, PTHR10183:SF329, 1 hit |
Pfami | View protein in Pfam PF01067, Calpain_III, 1 hit |
SMARTi | View protein in SMART SM00720, calpain_III, 1 hit |
SUPFAMi | SSF49758, SSF49758, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0S2Z3E6_HUMAN | |
Accessioni | A0A0S2Z3E6Primary (citable) accession number: A0A0S2Z3E6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | January 19, 2022 | |
This is version 20 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |