UniProtKB - A0A0S2Z3D0 (A0A0S2Z3D0_HUMAN)
Protein
Carbonic anhydrase
Gene
CA9
Organism
Homo sapiens (Human)
Status
Functioni
Reversible hydration of carbon dioxide.UniRule annotation
Catalytic activityi
- EC:4.2.1.1UniRule annotation
Cofactori
Zn2+UniRule annotation
GO - Molecular functioni
- carbonate dehydratase activity Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- morphogenesis of an epithelium Source: Ensembl
- response to drug Source: Ensembl
- response to hypoxia Source: Ensembl
- response to testosterone Source: Ensembl
- secretion Source: Ensembl
Keywordsi
Molecular function | LyaseUniRule annotation |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CA9Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma Membrane
- basolateral plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 415 – 433 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 37 | Sequence analysisAdd BLAST | 37 | |
ChainiPRO_5006608191 | 38 – 459 | Carbonic anhydraseSequence analysisAdd BLAST | 422 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 139 – 390 | Alpha-carbonic anhydraseInterPro annotationAdd BLAST | 252 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 42 – 154 | DisorderedSequence analysisAdd BLAST | 113 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 57 – 93 | AcidicSequence analysisAdd BLAST | 37 | |
Compositional biasi | 94 – 111 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 126 – 141 | PolyampholyteSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OMAi | VQMRRQQ |
OrthoDBi | 1377476at2759 |
PhylomeDBi | A0A0S2Z3D0 |
Family and domain databases
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR018429, CA9 IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class IPR018338, Carbonic_anhydrase_a-class_CS |
PANTHERi | PTHR18952, PTHR18952, 1 hit PTHR18952:SF18, PTHR18952:SF18, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS00162, ALPHA_CA_1, 1 hit PS51144, ALPHA_CA_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
A0A0S2Z3D0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPLCPSPWL PLLIPAPAPG LTVQLLLSLL LLVPVHPQRL PRMQEDSPLG
60 70 80 90 100
GGSSGEDDPL GEEDLPSEED SPREEDPPGE EDLPGEEDLP GEEDLPEVKP
110 120 130 140 150
KSEEEGSLKL EDLPTVEAPG DPQEPQNNAH RDKEGDDQSH WRYGGDPPWP
160 170 180 190 200
RVSPACAGRF QSPVDIRPQL AAFCPALRPL ELLGFQLPPL PELRLRNNGH
210 220 230 240 250
SVQLTLPPGL EMALGPGREY RALQLHLHWG AAGRPGSEHT VEGHRFPAEI
260 270 280 290 300
HVVHLSTAFA RVDEALGRPG GLAVLAAFLE EGPEENSAYE QLLSRLEEIA
310 320 330 340 350
EEGSETQVPG LDISALLPSD FSRYFQYEGS LTTPPCAQGV IWTVFNQTVM
360 370 380 390 400
LSAKQLHTLS DTLWGPGDSR LQLNFRATQP LNGRVIEASF PAGVDSSPRA
410 420 430 440 450
AEPVQLNSCL AAGDILALVF GLLFAVTSVA FLVQMRRQHR RGTKGGVSYR
PAEVAETGA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 459 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU177952 mRNA Translation: ALQ33410.1 |
RefSeqi | NP_001207.2, NM_001216.2 |
Genome annotation databases
GeneIDi | 768 |
KEGGi | hsa:768 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU177952 mRNA Translation: ALQ33410.1 |
RefSeqi | NP_001207.2, NM_001216.2 |
3D structure databases
SMRi | A0A0S2Z3D0 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A0S2Z3D0 |
Protocols and materials databases
Antibodypediai | 3915, 1241 antibodies |
Genome annotation databases
GeneIDi | 768 |
KEGGi | hsa:768 |
Organism-specific databases
CTDi | 768 |
Phylogenomic databases
OMAi | VQMRRQQ |
OrthoDBi | 1377476at2759 |
PhylomeDBi | A0A0S2Z3D0 |
Miscellaneous databases
BioGRID-ORCSi | 768, 17 hits in 877 CRISPR screens |
ChiTaRSi | CA9, human |
GenomeRNAii | 768 |
Gene expression databases
ExpressionAtlasi | A0A0S2Z3D0, baseline and differential |
Family and domain databases
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR018429, CA9 IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class IPR018338, Carbonic_anhydrase_a-class_CS |
PANTHERi | PTHR18952, PTHR18952, 1 hit PTHR18952:SF18, PTHR18952:SF18, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS00162, ALPHA_CA_1, 1 hit PS51144, ALPHA_CA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0S2Z3D0_HUMAN | |
Accessioni | A0A0S2Z3D0Primary (citable) accession number: A0A0S2Z3D0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | February 10, 2021 | |
This is version 32 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |