ADA

Functionⁱ

Catalytic activityⁱ

adenosine
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
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See the description of this molecule in ChEBI.
+
H₂O
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See the description of this molecule in ChEBI.
=
inosine
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
NH₄⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
ARBA annotation
Automatic assertion according to rulesⁱ
- ARBA:ARBA00001466
EC:
3.5.4.4
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
ARBA annotation
Automatic assertion according to rulesⁱ
- ARBA:ARBA00001466
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
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adenosine
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+
H⁺
+
H₂O
=
inosine
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NH₄⁺
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Cofactorⁱ

Zn²⁺ARBA annotation

GO - Molecular functionⁱ

adenosine deaminase activity Source: UniProtKB-EC
purine nucleoside binding Source: Ensembl
zinc ion binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenosine catabolic process Source: Ensembl
aging Source: Ensembl
AMP catabolic process Source: Ensembl
dAMP catabolic process Source: Ensembl
dATP catabolic process Source: Ensembl
deoxyadenosine catabolic process Source: Ensembl
embryonic digestive tract development Source: Ensembl
germinal center B cell differentiation Source: Ensembl
histamine secretion Source: Ensembl
hypoxanthine biosynthetic process Source: Ensembl
inosine biosynthetic process Source: Ensembl
liver development Source: Ensembl
lung alveolus development Source: Ensembl
negative regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
negative regulation of inflammatory response Source: Ensembl
negative regulation of leukocyte migration Source: Ensembl
negative regulation of mature B cell apoptotic process Source: Ensembl
negative regulation of mucus secretion Source: Ensembl
negative regulation of penile erection Source: Ensembl
negative regulation of thymocyte apoptotic process Source: Ensembl
Peyer's patch development Source: Ensembl
placenta development Source: Ensembl
positive regulation of alpha-beta T cell differentiation Source: Ensembl
positive regulation of B cell proliferation Source: Ensembl
positive regulation of calcium-mediated signaling Source: Ensembl
positive regulation of germinal center formation Source: Ensembl
positive regulation of heart rate Source: Ensembl
positive regulation of smooth muscle contraction Source: Ensembl
positive regulation of T cell differentiation in thymus Source: Ensembl
positive regulation of T cell receptor signaling pathway Source: Ensembl
purine ribonucleoside monophosphate biosynthetic process Source: InterPro
response to drug Source: Ensembl
response to hydrogen peroxide Source: Ensembl
response to hypoxia Source: Ensembl
response to morphine Source: Ensembl
response to vitamin E Source: Ensembl
trophectodermal cell differentiation Source: Ensembl
xanthine biosynthetic process Source: Ensembl

Complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Adenosine aminohydrolaseARBA annotation (EC:3.5.4.4ARBA annotation) Alternative name(s): Adenosine deaminaseARBA annotation
Gene namesⁱ	Name:ADAImported ORF Names:hCG_38105Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	A0A0S2Z381, baseline and differential

ExpressionAtlasⁱ

A0A0S2Z381, baseline and differential

Interactionⁱ

Chemistry databases

BindingDBⁱ	A0A0S2Z381

BindingDBⁱ

A0A0S2Z381

Structureⁱ

3D structure databases

SMRⁱ	A0A0S2Z381
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	9 – 345	A_deaminaseInterPro annotationAdd BLAST		337

Sequence similaritiesⁱ

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.ARBA annotation

Phylogenomic databases

OMAⁱ	QWCGADR
Database of Orthologous Groups More...OrthoDBⁱ	1045809at2759

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01320, ADA, 1 hit
HAMAPⁱ	MF_00540, A_deaminase, 1 hit
InterProⁱ	View protein in InterPro IPR006650, A/AMP_deam_AS IPR001365, A/AMP_deaminase_dom IPR028893, A_deaminase IPR006330, Ado/ade_deaminase IPR032466, Metal_Hydrolase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00962, A_deaminase, 1 hit
SUPFAMⁱ	SSF51556, SSF51556, 1 hit
TIGRFAMsⁱ	TIGR01430, aden_deam, 1 hit
PROSITEⁱ	View protein in PROSITE PS00485, A_DEAMINASE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragment.

A0A0S2Z381-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAQTPAFDKP KVELHVHLDG SIKPETILYY GRRRGIALPA NTAEGLLNVI 
        60         70         80         90        100
GMDKPLTLPD FLAKFDYYMP AIAGCREAIK RIAYEFVEMK AKEGVVYVEV 
       110        120        130        140        150
RYSPHLLANS KVEPIPWNQA EGDLTPDEVV ALVGQGLQEG ERDFGVKARS 
       160        170        180        190        200
ILCCMRHQPN WSPKVVELCK KYQQQTVVAI DLAGDETIPG SSLLPGHVQA 
       210        220        230        240        250
YQEAVKSGIH RTVHAGEVGS AEVVKEAVDI LKTERLGHGY HTLEDQALYN 
       260        270        280        290        300
RLRQENMHFE ICPWSSYLTG AWKPDTEHAV IRLKNDQANY SLNTDDPLIF 
       310        320        330        340        350
KSTLDTDYQM TKRDMGFTEE EFKRLNINAA KSSFLPEDEK RELLDLLYKA 
       360 
YGMPPSASAG QNL

Length:363

Mass (Da):40,764

Last modified:February 17, 2016 - v1

Checksum:ⁱ786BC5085CA9AFCB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	363	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	KU177892 mRNA Translation: ALQ33350.1 CH471077 Genomic DNA Translation: EAW75906.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000013.2, NM_000022.3

Genome annotation databases

GeneIDⁱ	100
KEGGⁱ	hsa:100

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A0S2Z381	Adenosine deaminase	)	HUMAN		363	UniRef100_P00813

Protein	Similar proteins		Species	Score	Length	Source
A0A0S2Z381	Adenosine deaminase	)	HUMAN		363	UniRef90_P00813
Adenosine aminohydrolase		CERAT		449
Adenosine deaminase		PAPAN		425
Adenosine deaminase		MANLE		425
Uncharacterized protein		COLAP		424
+28

Protein	Similar proteins		Species	Score	Length	Source
A0A0S2Z381	Adenosine deaminase	)	HUMAN		363	UniRef50_P00813
Adenosine deaminase	)	BOVIN		363
Adenosine aminohydrolase		CERAT		449
Adenosine deaminase		MANLE		425
Adenosine deaminase		PAPAN		425
+277

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	KU177892 mRNA Translation: ALQ33350.1 CH471077 Genomic DNA Translation: EAW75906.1
RefSeqⁱ	NP_000013.2, NM_000022.3

3D structure databases

SMRⁱ	A0A0S2Z381
ModBaseⁱ	Search...

Chemistry databases

BindingDBⁱ	A0A0S2Z381

BindingDBⁱ

A0A0S2Z381

Protocols and materials databases

Antibodypediaⁱ	700, 491 antibodies
The DNASU plasmid repository More...DNASUⁱ	100

Genome annotation databases

GeneIDⁱ	100
KEGGⁱ	hsa:100

Organism-specific databases

CTDⁱ	100

CTDⁱ

100

Phylogenomic databases

OMAⁱ	QWCGADR
OrthoDBⁱ	1045809at2759

Miscellaneous databases

BioGRID-ORCSⁱ	100, 8 hits in 996 CRISPR screens
ChiTaRSⁱ	ADA, human
GenomeRNAiⁱ	100

Gene expression databases

ExpressionAtlasⁱ	A0A0S2Z381, baseline and differential

ExpressionAtlasⁱ

A0A0S2Z381, baseline and differential

Family and domain databases

CDDⁱ	cd01320, ADA, 1 hit
HAMAPⁱ	MF_00540, A_deaminase, 1 hit
InterProⁱ	View protein in InterPro IPR006650, A/AMP_deam_AS IPR001365, A/AMP_deaminase_dom IPR028893, A_deaminase IPR006330, Ado/ade_deaminase IPR032466, Metal_Hydrolase
Pfamⁱ	View protein in Pfam PF00962, A_deaminase, 1 hit
SUPFAMⁱ	SSF51556, SSF51556, 1 hit
TIGRFAMsⁱ	TIGR01430, aden_deam, 1 hit
PROSITEⁱ	View protein in PROSITE PS00485, A_DEAMINASE, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A0S2Z381_HUMAN
Accessionⁱ	A0A0S2Z381Primary (citable) accession number: A0A0S2Z381
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 17, 2016
	Last sequence update:	February 17, 2016
	Last modified:	April 7, 2021
	This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A0A0S2Z381 (A0A0S2Z381_HUMAN)

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Adenosine aminohydrolase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytosol

Extracellular region or secreted

Plasma Membrane

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ