UniProtKB - A0A0S2Z381 (A0A0S2Z381_HUMAN)
Protein
Adenosine aminohydrolase
Gene
ADA
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.5.4.4ARBA annotation
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- adenosine deaminase activity Source: UniProtKB-EC
- purine nucleoside binding Source: Ensembl
- zinc ion binding Source: Ensembl
GO - Biological processi
- adenosine catabolic process Source: Ensembl
- aging Source: Ensembl
- dATP catabolic process Source: Ensembl
- deoxyadenosine catabolic process Source: Ensembl
- embryonic digestive tract development Source: Ensembl
- germinal center B cell differentiation Source: Ensembl
- histamine secretion Source: Ensembl
- hypoxanthine biosynthetic process Source: Ensembl
- inosine biosynthetic process Source: Ensembl
- liver development Source: Ensembl
- lung alveolus development Source: Ensembl
- negative regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
- negative regulation of inflammatory response Source: Ensembl
- negative regulation of leukocyte migration Source: Ensembl
- negative regulation of mature B cell apoptotic process Source: Ensembl
- negative regulation of mucus secretion Source: Ensembl
- negative regulation of penile erection Source: Ensembl
- negative regulation of thymocyte apoptotic process Source: Ensembl
- Peyer's patch development Source: Ensembl
- placenta development Source: Ensembl
- positive regulation of alpha-beta T cell differentiation Source: Ensembl
- positive regulation of B cell proliferation Source: Ensembl
- positive regulation of calcium-mediated signaling Source: Ensembl
- positive regulation of germinal center formation Source: Ensembl
- positive regulation of heart rate Source: Ensembl
- positive regulation of smooth muscle contraction Source: Ensembl
- positive regulation of T cell differentiation in thymus Source: Ensembl
- positive regulation of T cell receptor signaling pathway Source: Ensembl
- purine ribonucleoside monophosphate biosynthetic process Source: InterPro
- response to drug Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to hypoxia Source: Ensembl
- response to morphine Source: Ensembl
- response to vitamin E Source: Ensembl
- trophectodermal cell differentiation Source: Ensembl
- xanthine biosynthetic process Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Adenosine aminohydrolaseARBA annotation (EC:3.5.4.4ARBA annotation)Alternative name(s): Adenosine deaminaseARBA annotation |
Gene namesi | Name:ADAImported ORF Names:hCG_38105Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Extracellular side ARBA annotation
Other locations
- Cell junction ARBA annotation
- Cytoplasmic vesicle lumen ARBA annotation
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular space Source: Ensembl
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cell junction Source: UniProtKB-SubCell
- cytoplasmic vesicle lumen Source: UniProtKB-SubCell
- dendrite cytoplasm Source: Ensembl
- neuronal cell body Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 345 | A_deaminaseInterPro annotationAdd BLAST | 337 |
Sequence similaritiesi
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.ARBA annotation
Phylogenomic databases
OMAi | QWCGADR |
OrthoDBi | 1045809at2759 |
Family and domain databases
CDDi | cd01320, ADA, 1 hit |
HAMAPi | MF_00540, A_deaminase, 1 hit |
InterProi | View protein in InterPro IPR006650, A/AMP_deam_AS IPR001365, A/AMP_deaminase_dom IPR028893, A_deaminase IPR006330, Ado/ade_deaminase IPR032466, Metal_Hydrolase |
Pfami | View protein in Pfam PF00962, A_deaminase, 1 hit |
SUPFAMi | SSF51556, SSF51556, 1 hit |
TIGRFAMsi | TIGR01430, aden_deam, 1 hit |
PROSITEi | View protein in PROSITE PS00485, A_DEAMINASE, 1 hit |
i Sequence
Sequence statusi: Fragment.
A0A0S2Z381-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQTPAFDKP KVELHVHLDG SIKPETILYY GRRRGIALPA NTAEGLLNVI
60 70 80 90 100
GMDKPLTLPD FLAKFDYYMP AIAGCREAIK RIAYEFVEMK AKEGVVYVEV
110 120 130 140 150
RYSPHLLANS KVEPIPWNQA EGDLTPDEVV ALVGQGLQEG ERDFGVKARS
160 170 180 190 200
ILCCMRHQPN WSPKVVELCK KYQQQTVVAI DLAGDETIPG SSLLPGHVQA
210 220 230 240 250
YQEAVKSGIH RTVHAGEVGS AEVVKEAVDI LKTERLGHGY HTLEDQALYN
260 270 280 290 300
RLRQENMHFE ICPWSSYLTG AWKPDTEHAV IRLKNDQANY SLNTDDPLIF
310 320 330 340 350
KSTLDTDYQM TKRDMGFTEE EFKRLNINAA KSSFLPEDEK RELLDLLYKA
360
YGMPPSASAG QNL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 363 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU177892 mRNA Translation: ALQ33350.1 CH471077 Genomic DNA Translation: EAW75906.1 |
RefSeqi | NP_000013.2, NM_000022.3 |
Genome annotation databases
GeneIDi | 100 |
KEGGi | hsa:100 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU177892 mRNA Translation: ALQ33350.1 CH471077 Genomic DNA Translation: EAW75906.1 |
RefSeqi | NP_000013.2, NM_000022.3 |
3D structure databases
SMRi | A0A0S2Z381 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A0S2Z381 |
Protocols and materials databases
Antibodypediai | 700, 483 antibodies |
Genome annotation databases
GeneIDi | 100 |
KEGGi | hsa:100 |
Organism-specific databases
CTDi | 100 |
Phylogenomic databases
OMAi | QWCGADR |
OrthoDBi | 1045809at2759 |
Miscellaneous databases
BioGRID-ORCSi | 100, 6 hits in 843 CRISPR screens |
ChiTaRSi | ADA, human |
GenomeRNAii | 100 |
Gene expression databases
ExpressionAtlasi | A0A0S2Z381, baseline and differential |
Family and domain databases
CDDi | cd01320, ADA, 1 hit |
HAMAPi | MF_00540, A_deaminase, 1 hit |
InterProi | View protein in InterPro IPR006650, A/AMP_deam_AS IPR001365, A/AMP_deaminase_dom IPR028893, A_deaminase IPR006330, Ado/ade_deaminase IPR032466, Metal_Hydrolase |
Pfami | View protein in Pfam PF00962, A_deaminase, 1 hit |
SUPFAMi | SSF51556, SSF51556, 1 hit |
TIGRFAMsi | TIGR01430, aden_deam, 1 hit |
PROSITEi | View protein in PROSITE PS00485, A_DEAMINASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0S2Z381_HUMAN | |
Accessioni | A0A0S2Z381Primary (citable) accession number: A0A0S2Z381 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | December 2, 2020 | |
This is version 37 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |