UniProtKB - A0A0S2Z349 (A0A0S2Z349_HUMAN)
Protein
Submitted name:
CD40 molecule TNF receptor superfamily member 5 isoform 3
Gene
CD40
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- signaling receptor activity Source: InterPro
GO - Biological processi
- B cell activation Source: InterPro
- regulation of immune response Source: InterPro
Keywordsi
Molecular function | ReceptorImported |
Names & Taxonomyi
Protein namesi | Submitted name: CD40 molecule TNF receptor superfamily member 5 isoform 3Imported |
Gene namesi | Name:CD40Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma Membrane
- external side of plasma membrane Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 142 – 163 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5006608188 | 21 – 225 | Sequence analysisAdd BLAST | 205 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 ↔ 51 | PROSITE-ProRule annotation | ||
Disulfide bondi | 41 ↔ 59 | PROSITE-ProRule annotation | ||
Disulfide bondi | 62 ↔ 77 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationProteomic databases
PeptideAtlasi | A0A0S2Z349 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 59 | TNFR-CysInterPro annotationAdd BLAST | 35 | |
Repeati | 25 – 59 | TNFR-CysPROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 61 – 103 | TNFR-CysInterPro annotationAdd BLAST | 43 | |
Repeati | 61 – 103 | TNFR-CysPROSITE-ProRule annotationAdd BLAST | 43 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 170 – 225 | DisorderedSequence analysisAdd BLAST | 56 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OrthoDBi | 1038336at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR020435 TNFR_5 |
Pfami | View protein in Pfam PF00020 TNFR_c6, 1 hit |
PRINTSi | PR01922 TNFACTORR5 |
SMARTi | View protein in SMART SM00208 TNFR, 3 hits |
PROSITEi | View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit PS50050 TNFR_NGFR_2, 2 hits |
i Sequence
Sequence statusi: Fragment.
A0A0S2Z349-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRLPLQCVL WGCLLTAVHP EPPTACREKQ YLINSQCCSL CQPGQKLVSD
60 70 80 90 100
CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD
110 120 130 140 150
TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIGPQDRL RALVVIPIIF
160 170 180 190 200
GILFAILLVL VFIKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ
210 220
ETLHGCQPVT QEDGKESRIS VQERQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 225 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU177967 mRNA Translation: ALQ33425.1 |
RefSeqi | NP_001309351.1, NM_001322422.1 |
Genome annotation databases
GeneIDi | 958 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU177967 mRNA Translation: ALQ33425.1 |
RefSeqi | NP_001309351.1, NM_001322422.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A0S2Z349 |
Genome annotation databases
GeneIDi | 958 |
Organism-specific databases
CTDi | 958 |
Phylogenomic databases
OrthoDBi | 1038336at2759 |
Miscellaneous databases
ChiTaRSi | CD40 human |
GenomeRNAii | 958 |
Family and domain databases
InterProi | View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR020435 TNFR_5 |
Pfami | View protein in Pfam PF00020 TNFR_c6, 1 hit |
PRINTSi | PR01922 TNFACTORR5 |
SMARTi | View protein in SMART SM00208 TNFR, 3 hits |
PROSITEi | View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit PS50050 TNFR_NGFR_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0S2Z349_HUMAN | |
Accessioni | A0A0S2Z349Primary (citable) accession number: A0A0S2Z349 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 17, 2016 |
Last sequence update: | February 17, 2016 | |
Last modified: | July 31, 2019 | |
This is version 19 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |