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Entry version 13 (03 Jul 2019)
Sequence version 1 (17 Feb 2016)
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Protein
Submitted name:

ATP-binding cassette sub-family A ABCA2

Gene

ABCA2

Organism
Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi603 – 610ATPPROSITE-ProRule annotation8
Nucleotide bindingi1445 – 1452ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationImported, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP-binding cassette sub-family A ABCA2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCA2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicoverpa armigera (Cotton bollworm) (Heliothis armigera)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29058 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHelicoverpa

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei339 – 364HelicalSequence analysisAdd BLAST26
Transmembranei384 – 405HelicalSequence analysisAdd BLAST22
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Transmembranei489 – 512HelicalSequence analysisAdd BLAST24
Transmembranei1128 – 1148HelicalSequence analysisAdd BLAST21
Transmembranei1168 – 1197HelicalSequence analysisAdd BLAST30
Transmembranei1209 – 1227HelicalSequence analysisAdd BLAST19
Transmembranei1239 – 1260HelicalSequence analysisAdd BLAST22
Transmembranei1272 – 1292HelicalSequence analysisAdd BLAST21
Transmembranei1345 – 1363HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini571 – 800ABC transporterInterPro annotationAdd BLAST230
Domaini1413 – 1643ABC transporterInterPro annotationAdd BLAST231

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili675 – 695Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229 PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0S0G7V0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLETRHASA ATKFRLLMWK NFLQQWRHRL QTVVELFLPV VTMALVLILR
60 70 80 90 100
WQIPPYQIDT LTYPALPAHT LNYSTNILYA MNMEELSIAY SPASPVLDDV
110 120 130 140 150
MRTAVINLLT ANMKDLIPIF IDNLPPGIAN ITFPPDMNLN TSVIEEFVKS
160 170 180 190 200
RIRVVPYNSS YEIRGIYVDE ETTRSIIAAV EFDDKLYGAE QLSNNLSYSL
210 220 230 240 250
RFPERPRLNS FFQTGGRTWR SDGVFPVFEV PGPRFPHSWE GGNDPGYVNE
260 270 280 290 300
MFVALQQVIS TELVSRATGL DLKSFRVNIQ RYPHPPYLHD QSVDLLQFMF
310 320 330 340 350
PLFIMLSFSY TSVNIARAVT VEKELQLKET MKIMGLPTWL HWTAWFVKQF
360 370 380 390 400
IYLSITAVLL VVLLKVNWFT NDDGFSEYAV FTNTPWTVLL FFLILYLSCA
410 420 430 440 450
IFFSFMVSSI FSKGSTAALF MAVAWFLTYI PAFLLAMDIN MSTAVQVITC
460 470 480 490 500
FSINSAMSYG FQLMLAKEST GGLQWGDFMT SPETDTTRLV FGHVVIMLVV
510 520 530 540 550
DCLIYMLITL YLEQVLPGPF GTPKPWYFPF QLQFWFPNYK SKDAGLIFEN
560 570 580 590 600
DNSEFDDIIK EKDPTDHEVG VRMQNLTKIF GNNIAVNNLS LNIYDDQITV
610 620 630 640 650
LLGHNGAGKS TTISMLTGNL KLTRGTVNVA GYDMTSQSSA ARSHIGLCPQ
660 670 680 690 700
HNILFNELTV KEHLEFFARL KGFKGKELYD EIDSLIEKLE LQEKRDYPSK
710 720 730 740 750
GLSGGQKRRL CVGIALSGAA RVVLLDEPTS GMDPSSRRAL WELLQKEKKG
760 770 780 790 800
RSMILTTHFM DEADILGDRV AIMANGRLQC VGSPYFLKRH YGVGYTLVIV
810 820 830 840 850
KDTDFDFVKC SVLINSYIPG TIVKEDRGTE ITYNLVNDYS HVFEEMLNDL
860 870 880 890 900
ERNIDNIKFK NYGLVATTLE DVFMSVGADL SPINSESDDA ITTTTDSTID
910 920 930 940 950
DILKQEIDSS LEELDKDESN VTGLRLFGQQ VLAVWMKQWL VLIRSPWVMA
960 970 980 990 1000
LQFLAPVILI NSTLGVLRYV MSLSPTIRTR WLSLEEGYTE SETLLSFNGS
1010 1020 1030 1040 1050
VASSVGALAA QAYQSLFANS GVMDMEINAI GSQPIEEYYL NRTSDPVVMG
1060 1070 1080 1090 1100
SLRHRLLIGS TFDDDSATAW FSNFGYHDVA TSLAAIHSAI LRSKNSDAVL
1110 1120 1130 1140 1150
NVYNHPLEAS YIDQSDVQTM IAMLSMQLSS GIGSSVSIVS AVFIMFYIKE
1160 1170 1180 1190 1200
RMSGAKLLQN AAGVAPAVLW GGAAIFNWFW FLITCVSIVI SCVAFDVIGL
1210 1220 1230 1240 1250
STVHELGRMF LCVMVYGAAM LPLVYLLSLK FKGPAVGFVG FYFLNVLFGM
1260 1270 1280 1290 1300
MGAQVVEALS SPMLDTEQAA HILDYLLQFY PLYSLVTSIR FLNQVGLREY
1310 1320 1330 1340 1350
TCLQACEYLQ AVYPNLECNM ASMCEFHSDC CVRENPYFDW EEPGVLRYLL
1360 1370 1380 1390 1400
SMCFSCLMFW LLLMTIEYRV VQKVFTFKKT PPPIDESTLD EDVMTEARRA
1410 1420 1430 1440 1450
RVVPPTRRRE HALLAHDLSK YYGKHLAVDQ VSFSVNDGEC FGLLGVNGAG
1460 1470 1480 1490 1500
KTTTFKMLMG DESISSGEAY VSGHSVQRNL DRVHENIGYC PQFDALFGEL
1510 1520 1530 1540 1550
TGRQTLHMFA LMRGLRLRTA APSAETLAHA LGFFKHLDKR VHQYSGGTKR
1560 1570 1580 1590 1600
KLNTAIAFMG RTRLVFVDEP TTGVDPAAKR HVWRATRGVQ RAGRGVVLTS
1610 1620 1630 1640 1650
HSMEECEALC SRLTIMVNGR FQCLGTPQHL KNKFSQGFTL IIKMKTDDSE
1660 1670 1680 1690 1700
GDTQSVNSTT SVVDSVKLYV SENFESPKIM EEYHGLLTYY LPDRSMAWSR
1710 1720 1730 1740
MFGIMERAKQ ILQIEDYSIS QTTLEQIFLQ FTKYQREEGT TL
Length:1,742
Mass (Da):196,464
Last modified:February 17, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8C5D0051A5AB45B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KP259911 mRNA Translation: ALF46272.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KP259911 mRNA Translation: ALF46272.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0S0G7V0_HELAM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0S0G7V0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 17, 2016
Last sequence update: February 17, 2016
Last modified: July 3, 2019
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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