UniProtKB - A0A0R4J227 (A0A0R4J227_MOUSE)
Protein
Non-specific serine/threonine protein kinase
Gene
Mark2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: UniProtKB-KW
Keywordsi
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:Mark2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99638, Mark2 |
Subcellular locationi
Keywords - Cellular componenti
Cell projectionARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 304 | Protein kinaseInterPro annotationAdd BLAST | 252 | |
Domaini | 323 – 362 | UBAInterPro annotationAdd BLAST | 40 | |
Domaini | 673 – 722 | KA1InterPro annotationAdd BLAST | 50 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 46 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 373 – 576 | DisorderedSequence analysisAdd BLAST | 204 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 378 – 429 | PolarSequence analysisAdd BLAST | 52 | |
Compositional biasi | 430 – 444 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 463 – 576 | PolarSequence analysisAdd BLAST | 114 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155031 |
OrthoDBi | 1127668at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All
A0A0R4J227-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMLRGRNS ATSADEQPHI
60 70 80 90 100
GNYRLLKTIG KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE
110 120 130 140 150
VRIMKVLNHP NIVKLFEVIE TEKTLYLVME YASGGEVFDY LVAHGRMKEK
160 170 180 190 200
EARAKFRQIV SAVQYCHQKF IVHRDLKAEN LLLDADMNIK IADFGFSNEF
210 220 230 240 250
TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF
260 270 280 290 300
DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
310 320 330 340 350
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR
360 370 380 390 400
YNEVMATYLL LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS
410 420 430 440 450
ANPKQRRSSD QAVPAIPTSN SYSKKTQSNN AENKRPEEET GRKASSTAKV
460 470 480 490 500
PASPLPGLDR KKTTPAPSTN SVLSTSTNRS RNSPLLDRAS LGQASIQNGK
510 520 530 540 550
DSTAPQRVPV ASPSAHNISS SSGAPDRTNF PRGVSSRSTF HAGQLRQVRD
560 570 580 590 600
QQNLPYGVTP ASPSGHSQGR RGASGSIFSK FTSKFVRRNL NEPESKDRVE
610 620 630 640 650
TLRPHVVGSG GTDKDKEEFR EAKPRSLRFT WSMKTTSSME PNEMMREIRK
660 670 680 690 700
VLDANSCQSE LHERYMLLCV HGTPGHENFV QWEMEVCKLP RLSLNGVRFK
710 720
RISGTSMAFK NIASKIANEL KL
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ05512 | MARK2_MOUSE | Serine/threonine-protein kinase MAR... | Mark2 Emk | 776 | Annotation score: | ||
E9QMP6 | E9QMP6_MOUSE | Non-specific serine/threonine prote... | Mark2 | 776 | Annotation score: | ||
A0A0R4J0B1 | A0A0R4J0B1_MOUSE | Non-specific serine/threonine prote... | Mark2 | 731 | Annotation score: | ||
E9PYX3 | E9PYX3_MOUSE | Non-specific serine/threonine prote... | Mark2 | 716 | Annotation score: | ||
Q3T9A3 | Q3T9A3_MOUSE | Non-specific serine/threonine prote... | Mark2 | 743 | Annotation score: | ||
E9Q9N6 | E9Q9N6_MOUSE | Non-specific serine/threonine prote... | Mark2 | 707 | Annotation score: | ||
F6ZS70 | F6ZS70_MOUSE | Non-specific serine/threonine prote... | Mark2 | 776 | Annotation score: | ||
F7CVZ7 | F7CVZ7_MOUSE | Non-specific serine/threonine prote... | Mark2 | 307 | Annotation score: | ||
F6UY70 | F6UY70_MOUSE | Serine/threonine-protein kinase MAR... | Mark2 | 266 | Annotation score: | ||
E9Q2G8 | E9Q2G8_MOUSE | Serine/threonine-protein kinase MAR... | Mark2 | 89 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC129188 Genomic DNA No translation available. AC140307 Genomic DNA No translation available. |
RefSeqi | NP_001073857.1, NM_001080388.2 |
Genome annotation databases
Ensembli | ENSMUST00000164205; ENSMUSP00000127827; ENSMUSG00000024969 |
GeneIDi | 13728 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC129188 Genomic DNA No translation available. AC140307 Genomic DNA No translation available. |
RefSeqi | NP_001073857.1, NM_001080388.2 |
3D structure databases
SMRi | A0A0R4J227 |
ModBasei | Search... |
Proteomic databases
jPOSTi | A0A0R4J227 |
Protocols and materials databases
Antibodypediai | 15193, 448 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000164205; ENSMUSP00000127827; ENSMUSG00000024969 |
GeneIDi | 13728 |
Organism-specific databases
CTDi | 2011 |
MGIi | MGI:99638, Mark2 |
Phylogenomic databases
GeneTreei | ENSGT00940000155031 |
OrthoDBi | 1127668at2759 |
Miscellaneous databases
BioGRID-ORCSi | 13728, 3 hits in 18 CRISPR screens |
ChiTaRSi | Mark2, mouse |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | A0A0R4J227, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0R4J227_MOUSE | |
Accessioni | A0A0R4J227Primary (citable) accession number: A0A0R4J227 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 20, 2016 |
Last sequence update: | January 20, 2016 | |
Last modified: | December 2, 2020 | |
This is version 41 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |