UniProtKB - A0A0R4J1K4 (A0A0R4J1K4_MOUSE)
Protein
Anion exchange protein
Gene
Slc4a2
Organism
Mus musculus (Mouse)
Status
Functioni
Plasma membrane anion exchange protein of wide distribution.ARBA annotation
GO - Molecular functioni
- anion:anion antiporter activity Source: UniProtKB-KW
- inorganic anion exchanger activity Source: InterPro
Keywordsi
Biological process | Anion exchangeARBA annotation, AntiportARBA annotation, Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Anion exchange proteinUniRule annotation |
Gene namesi | Name:Slc4a2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109351, Slc4a2 |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 691 – 712 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 733 – 756 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 776 – 801 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 808 – 826 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 883 – 900 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 916 – 936 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 973 – 992 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 1013 – 1037 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 1098 – 1118 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 1145 – 1163 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 1169 – 1190 | HelicalUniRule annotationAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 334 – 601 | Band_3_cytoInterPro annotationAdd BLAST | 268 | |
Domaini | 657 – 1150 | HCO3_cotranspInterPro annotationAdd BLAST | 494 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 224 | DisorderedSequence analysisAdd BLAST | 224 | |
Regioni | 272 – 302 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 431 – 452 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 40 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 47 – 84 | PolyampholyteSequence analysisAdd BLAST | 38 | |
Compositional biasi | 288 – 302 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotationARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158259 |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002978, Anion_exchange_2 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF14, PTHR11453:SF14, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01188, ANIONEXHNGR2 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
A0A0R4J1K4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQPEPESLS PGTPGFPEQE EDELRTLGVE RFEEILQEAG SRGGEEPGRS
60 70 80 90 100
YGEEDFEYHR QSSHHIHHPL STHLPPDARR RKTPQGPGRK PRRRPGASPT
110 120 130 140 150
GETPTIEEGE EDEEEASEAE GFRAPPQQPS PATTPSAVQF FLQEDEGAER
160 170 180 190 200
KPERTSPSPP TQTPHQEAAP RASKGAQTGT LVEEMVAVAS GTAGGDDGGA
210 220 230 240 250
AGRPLTKAQP GHRSYNLQER RRIGSMTGVE QALLPRVPTD ESEAQTLATA
260 270 280 290 300
DLDLMKSHRF EDVPGVRRHL VRKNAKGSTQ AAREGREPGP TPRARPRAPH
310 320 330 340 350
KPHEVFVELN ELLLDKNQEP QWRETARWIK FEEDVEEETE RWGKPHVASL
360 370 380 390 400
SFRSLLELRR TLAHGAVLLD LDQQTLPGVA HQVVEQMVIS DQIKAEDRAN
410 420 430 440 450
VLRALLLKHS HPSDEKEFSF PRNISAGSLG SLLGHHHAQG TESDPHVTEP
460 470 480 490 500
LIGGVPETRL EVDRERELPP PAPPAGITRS KSKHELKLLE KIPENAEATV
510 520 530 540 550
VLVGCVEFLS RPTMAFVRLR EAVELDAVLE VPVPVRFLFL LLGPSSANMD
560 570 580 590 600
YHEIGRSIST LMSDKQFHEA AYLADERDDL LTAINAFLDC SVVLPPSEVQ
610 620 630 640 650
GEELLRSVAH FQRQMLKKRE EQGRLLPPGA GLEPKSAQDK ALLQMVEVAG
660 670 680 690 700
AAEDDPLRRT GRPFGGLIRD VRRRYPHYLS DFRDALDPQC LAAVIFIYFA
710 720 730 740 750
ALSPAITFGG LLGEKTKDLI GVSELIMSTA LQGVVFCLLG AQPLLVIGFS
760 770 780 790 800
GPLLVFEEAF FSFCSSNELE YLVGRVWIGF WLVFLALLMV ALEGSFLVRF
810 820 830 840 850
VSRFTQEIFA FLISLIFIYE TFYKLIKIFQ EHPLHGCSGS NDSEAGSSSS
860 870 880 890 900
SNMTWATTIL VPDNSSASGQ SGQEKPRGQP NTALLSLVLM AGTFFIAFFL
910 920 930 940 950
RKFKNSRFFP GRIRRVIGDF GVPIAILIMV LVDYSIEDTY TQKLSVPSGF
960 970 980 990 1000
SVTAPDKRGW VINPLGEKTP FPVWMMVASL LPAVLVFILI FMETQITTLI
1010 1020 1030 1040 1050
ISKKERMLQK GSGFHLDLLL IVAMGGICAL FGLPWLAAAT VRSVTHANAL
1060 1070 1080 1090 1100
TVMSKAVAPG DKPKIQEVKE QRVTGLLVAL LVGLSMVIGD LLRQIPLAVL
1110 1120 1130 1140 1150
FGIFLYMGVT SLNGIQFYER LHLLLMPPKH HPDVTYVKKV RTMRMHLFTA
1160 1170 1180 1190 1200
LQLLCLALLW AVMSTAASLA FPFILILTVP LRMVVLTRIF TEREMKCLDA
1210 1220
NEAEPVFDEC EGVDEYNEMP MPV
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP13808 | B3A2_MOUSE | Anion exchange protein 2 | Slc4a2 Ae2 | 1,237 | Annotation score: | ||
A0A0R4J101 | A0A0R4J101_MOUSE | Anion exchange protein | Slc4a2 | 1,237 | Annotation score: | ||
A0A0R4J1K9 | A0A0R4J1K9_MOUSE | Anion exchange protein | Slc4a2 | 1,228 | Annotation score: | ||
D3YUF1 | D3YUF1_MOUSE | Anion exchange protein 2 | Slc4a2 | 121 | Annotation score: | ||
D3Z5G3 | D3Z5G3_MOUSE | Anion exchange protein 2 | Slc4a2 | 131 | Annotation score: | ||
A0A1C7ZN01 | A0A1C7ZN01_MOUSE | Anion exchange protein 2 | Slc4a2 | 9 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113055 Genomic DNA No translation available. AC120353 Genomic DNA No translation available. |
RefSeqi | XP_006535719.1, XM_006535656.3 |
Genome annotation databases
Ensembli | ENSMUST00000115047; ENSMUSP00000110699; ENSMUSG00000028962 |
GeneIDi | 20535 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113055 Genomic DNA No translation available. AC120353 Genomic DNA No translation available. |
RefSeqi | XP_006535719.1, XM_006535656.3 |
3D structure databases
SMRi | A0A0R4J1K4 |
ModBasei | Search... |
Proteomic databases
jPOSTi | A0A0R4J1K4 |
Protocols and materials databases
Antibodypediai | 18690, 149 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000115047; ENSMUSP00000110699; ENSMUSG00000028962 |
GeneIDi | 20535 |
Organism-specific databases
CTDi | 6522 |
MGIi | MGI:109351, Slc4a2 |
Phylogenomic databases
GeneTreei | ENSGT00940000158259 |
Miscellaneous databases
BioGRID-ORCSi | 20535, 2 hits in 17 CRISPR screens |
ChiTaRSi | Slc4a2, mouse |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002978, Anion_exchange_2 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF14, PTHR11453:SF14, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01188, ANIONEXHNGR2 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0R4J1K4_MOUSE | |
Accessioni | A0A0R4J1K4Primary (citable) accession number: A0A0R4J1K4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 20, 2016 |
Last sequence update: | January 20, 2016 | |
Last modified: | February 10, 2021 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |