UniProtKB - A0A0R4J101 (A0A0R4J101_MOUSE)
Protein
Anion exchange protein
Gene
Slc4a2
Organism
Mus musculus (Mouse)
Status
Functioni
Plasma membrane anion exchange protein of wide distribution.ARBA annotation
GO - Molecular functioni
- anion:anion antiporter activity Source: UniProtKB-KW
- enzyme binding Source: Ensembl
- inorganic anion exchanger activity Source: InterPro
GO - Biological processi
- digestive tract development Source: Ensembl
- regulation of intracellular pH Source: Ensembl
- spermatogenesis Source: Ensembl
Keywordsi
Biological process | Anion exchangeARBA annotation, AntiportARBA annotation, Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Anion exchange proteinUniRule annotation |
Gene namesi | Name:Slc4a2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109351, Slc4a2 |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Plasma Membrane
- apical plasma membrane Source: Ensembl
- basolateral plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 705 – 726 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 747 – 770 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 790 – 815 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 822 – 840 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 897 – 914 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 930 – 950 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 987 – 1006 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 1027 – 1051 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 1112 – 1132 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 1159 – 1177 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 1183 – 1204 | HelicalUniRule annotationAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Sequence similaritiesi
Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotationARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158259 |
OMAi | SITHCPP |
OrthoDBi | 265068at2759 |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002978, Anion_exchange_2 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF14, PTHR11453:SF14, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01188, ANIONEXHNGR2 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
A0A0R4J101-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEDELRT LGVERFEEIL
60 70 80 90 100
QEAGSRGGEE PGRSYGEEDF EYHRQSSHHI HHPLSTHLPP DARRRKTPQG
110 120 130 140 150
PGRKPRRRPG ASPTGETPTI EEGEEDEEEA SEAEGFRAPP QQPSPATTPS
160 170 180 190 200
AVQFFLQEDE GAERKPERTS PSPPTQTPHQ EAAPRASKGA QTGTLVEEMV
210 220 230 240 250
AVASGTAGGD DGGAAGRPLT KAQPGHRSYN LQERRRIGSM TGVEQALLPR
260 270 280 290 300
VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSTQAAREGR
310 320 330 340 350
EPGPTPRARP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE
360 370 380 390 400
EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ
410 420 430 440 450
MVISDQIKAE DRANVLRALL LKHSHPSDEK EFSFPRNISA GSLGSLLGHH
460 470 480 490 500
HAQGTESDPH VTEPLIGGVP ETRLEVDRER ELPPPAPPAG ITRSKSKHEL
510 520 530 540 550
KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR
560 570 580 590 600
FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE RDDLLTAINA
610 620 630 640 650
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGAGLEPKS
660 670 680 690 700
AQDKALLQMV EVAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL
710 720 730 740 750
DPQCLAAVIF IYFAALSPAI TFGGLLGEKT KDLIGVSELI MSTALQGVVF
760 770 780 790 800
CLLGAQPLLV IGFSGPLLVF EEAFFSFCSS NELEYLVGRV WIGFWLVFLA
810 820 830 840 850
LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI KIFQEHPLHG
860 870 880 890 900
CSGSNDSEAG SSSSSNMTWA TTILVPDNSS ASGQSGQEKP RGQPNTALLS
910 920 930 940 950
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI
960 970 980 990 1000
EDTYTQKLSV PSGFSVTAPD KRGWVINPLG EKTPFPVWMM VASLLPAVLV
1010 1020 1030 1040 1050
FILIFMETQI TTLIISKKER MLQKGSGFHL DLLLIVAMGG ICALFGLPWL
1060 1070 1080 1090 1100
AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL LVALLVGLSM
1110 1120 1130 1140 1150
VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY
1160 1170 1180 1190 1200
VKKVRTMRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL
1210 1220 1230
TRIFTEREMK CLDANEAEPV FDECEGVDEY NEMPMPV
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP13808 | B3A2_MOUSE | Anion exchange protein 2 | Slc4a2 Ae2 | 1,237 | Annotation score: | ||
A0A0R4J1K4 | A0A0R4J1K4_MOUSE | Anion exchange protein | Slc4a2 | 1,223 | Annotation score: | ||
A0A0R4J1K9 | A0A0R4J1K9_MOUSE | Anion exchange protein | Slc4a2 | 1,228 | Annotation score: | ||
D3YUF1 | D3YUF1_MOUSE | Anion exchange protein 2 | Slc4a2 | 121 | Annotation score: | ||
D3Z5G3 | D3Z5G3_MOUSE | Anion exchange protein 2 | Slc4a2 | 131 | Annotation score: | ||
A0A1C7ZN01 | A0A1C7ZN01_MOUSE | Anion exchange protein 2 | Slc4a2 | 9 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113055 Genomic DNA No translation available. AC120353 Genomic DNA No translation available. |
RefSeqi | NP_001240821.1, NM_001253892.1 NP_033233.2, NM_009207.3 XP_006535713.1, XM_006535650.1 XP_006535714.1, XM_006535651.3 |
Genome annotation databases
Ensembli | ENSMUST00000080067; ENSMUSP00000078972; ENSMUSG00000028962 |
GeneIDi | 20535 |
KEGGi | mmu:20535 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113055 Genomic DNA No translation available. AC120353 Genomic DNA No translation available. |
RefSeqi | NP_001240821.1, NM_001253892.1 NP_033233.2, NM_009207.3 XP_006535713.1, XM_006535650.1 XP_006535714.1, XM_006535651.3 |
3D structure databases
SMRi | A0A0R4J101 |
ModBasei | Search... |
Proteomic databases
jPOSTi | A0A0R4J101 |
Protocols and materials databases
Antibodypediai | 18690, 149 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000080067; ENSMUSP00000078972; ENSMUSG00000028962 |
GeneIDi | 20535 |
KEGGi | mmu:20535 |
Organism-specific databases
CTDi | 6522 |
MGIi | MGI:109351, Slc4a2 |
Phylogenomic databases
GeneTreei | ENSGT00940000158259 |
OMAi | SITHCPP |
OrthoDBi | 265068at2759 |
Miscellaneous databases
BioGRID-ORCSi | 20535, 2 hits in 17 CRISPR screens |
ChiTaRSi | Slc4a2, mouse |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002978, Anion_exchange_2 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF14, PTHR11453:SF14, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01188, ANIONEXHNGR2 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0R4J101_MOUSE | |
Accessioni | A0A0R4J101Primary (citable) accession number: A0A0R4J101 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 20, 2016 |
Last sequence update: | January 20, 2016 | |
Last modified: | February 10, 2021 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |