UniProtKB - A0A0R4J0V0 (A0A0R4J0V0_MOUSE)
Protein
Submitted name:
Beta-Ala-His dipeptidase
Gene
Cndp1
Organism
Mus musculus (Mouse)
Status
Functioni
Cofactori
Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 107 | Manganese 2UniRule annotation | 1 | |
Active sitei | 109 | UniRule annotation | 1 | |
Metal bindingi | 140 | Manganese 1UniRule annotation | 1 | |
Metal bindingi | 140 | Manganese 2UniRule annotation | 1 | |
Active sitei | 174 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 175 | Manganese 1UniRule annotation | 1 | |
Metal bindingi | 203 | Manganese 2UniRule annotation | 1 | |
Sitei | 236 | Important for catalytic activityUniRule annotation | 1 | |
Metal bindingi | 453 | Manganese 1UniRule annotation | 1 |
GO - Molecular functioni
- carboxypeptidase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- metallodipeptidase activity Source: InterPro
GO - Biological processi
- regulation of cellular protein metabolic process Source: Ensembl
Keywordsi
Molecular function | CarboxypeptidaseARBA annotation, Hydrolase, Protease |
Ligand | ManganeseUniRule annotation, Metal-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Beta-Ala-His dipeptidaseImported |
Gene namesi | Name:Cndp1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2451097, Cndp1 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 216 – 374 | M20_dimerInterPro annotationAdd BLAST | 159 |
Sequence similaritiesi
Belongs to the peptidase M20A family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000160484 |
OMAi | CKGNIVM |
OrthoDBi | 733473at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001261, ArgE/DapE_CS IPR017153, CNDP/DUG1 IPR002933, Peptidase_M20 IPR011650, Peptidase_M20_dimer |
Pfami | View protein in Pfam PF07687, M20_dimer, 1 hit PF01546, Peptidase_M20, 1 hit |
PIRSFi | PIRSF037242, CNDP_dipeptidase, 1 hit |
PROSITEi | View protein in PROSITE PS00759, ARGE_DAPE_CPG2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0A0R4J0V0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSSAHSGLL EKLFHYIDLH QDEFVQTLKE WVAIESDSVQ PVPRLRQKLF
60 70 80 90 100
QMMALAADKL RNLGAGVESI DLGSQQMPDG QSLPIPPILL AELGSDPEKP
110 120 130 140 150
TVCFYGHLDV QPAQKDDGWL TDPYTLTEVD GKLYGRGATD NKGPVLAWIN
160 170 180 190 200
AVSTFRALQQ DLPVNIKLIL EGMEEAGSIA LEELVMREKD HFFSSVDYIV
210 220 230 240 250
ISDNLWLSQR KPALTYGTRG NCYFTVEVKC RDQDFHSGTF GGILNEPMAD
260 270 280 290 300
LVALLGSLVD SSGHILIPGI YDQMAPITEG EKTMYKNIDM DLEEYQNINQ
310 320 330 340 350
VEKFLFDTKE ELLMHLWRYP SLSIHGIEGA FDEPGTKTVI PGRVLGKFSI
360 370 380 390 400
RLVPTMSPSV VEKQVTQHLE AVFSKRNSFN KMAVSMVLGL HPWTANVNDT
410 420 430 440 450
QYLAAQRTIK TVFGVNPDMI RDGSTIPIAK IFQAITQKSV MMLPLGAVDD
460 470 480 490
GEHSQNEKIN RWNYIQGSKL FAAFFLELSK QHSGHQMPSS VY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8BUG2 | CNDP1_MOUSE | Beta-Ala-His dipeptidase | Cndp1 Cn1 | 492 | Annotation score: | ||
A0A494B9E5 | A0A494B9E5_MOUSE | Beta-Ala-His dipeptidase | Cndp1 | 74 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC121513 Genomic DNA No translation available. AC124187 Genomic DNA No translation available. |
RefSeqi | NP_803233.2, NM_177450.4 |
Genome annotation databases
Ensembli | ENSMUST00000070139; ENSMUSP00000069699; ENSMUSG00000056162 |
GeneIDi | 338403 |
KEGGi | mmu:338403 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC121513 Genomic DNA No translation available. AC124187 Genomic DNA No translation available. |
RefSeqi | NP_803233.2, NM_177450.4 |
3D structure databases
SMRi | A0A0R4J0V0 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 2197, 377 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000070139; ENSMUSP00000069699; ENSMUSG00000056162 |
GeneIDi | 338403 |
KEGGi | mmu:338403 |
Organism-specific databases
CTDi | 84735 |
MGIi | MGI:2451097, Cndp1 |
Phylogenomic databases
GeneTreei | ENSGT00940000160484 |
OMAi | CKGNIVM |
OrthoDBi | 733473at2759 |
Miscellaneous databases
BioGRID-ORCSi | 338403, 0 hits in 17 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | A0A0R4J0V0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001261, ArgE/DapE_CS IPR017153, CNDP/DUG1 IPR002933, Peptidase_M20 IPR011650, Peptidase_M20_dimer |
Pfami | View protein in Pfam PF07687, M20_dimer, 1 hit PF01546, Peptidase_M20, 1 hit |
PIRSFi | PIRSF037242, CNDP_dipeptidase, 1 hit |
PROSITEi | View protein in PROSITE PS00759, ARGE_DAPE_CPG2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0R4J0V0_MOUSE | |
Accessioni | A0A0R4J0V0Primary (citable) accession number: A0A0R4J0V0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 20, 2016 |
Last sequence update: | January 20, 2016 | |
Last modified: | February 10, 2021 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |