UniProtKB - A0A0R4J097 (A0A0R4J097_MOUSE)
Protein
Submitted name:
Transforming growth factor beta receptor type 3
Gene
Tgfbr3
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- activin binding Source: Ensembl
- coreceptor activity Source: Ensembl
- fibroblast growth factor binding Source: Ensembl
- heparin binding Source: Ensembl
- SMAD binding Source: Ensembl
- transforming growth factor beta binding Source: Ensembl
- transforming growth factor beta receptor activity, type III Source: Ensembl
- type II transforming growth factor beta receptor binding Source: Ensembl
GO - Biological processi
- animal organ regeneration Source: Ensembl
- BMP signaling pathway Source: Ensembl
- cardiac epithelial to mesenchymal transition Source: Ensembl
- immune response Source: Ensembl
- intracellular signal transduction Source: Ensembl
- negative regulation of cellular component movement Source: Ensembl
- negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- pathway-restricted SMAD protein phosphorylation Source: Ensembl
- positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- regulation of protein binding Source: Ensembl
- response to follicle-stimulating hormone Source: Ensembl
- response to hypoxia Source: Ensembl
- response to luteinizing hormone Source: Ensembl
- response to prostaglandin E Source: Ensembl
- transforming growth factor beta receptor complex assembly Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Transforming growth factor beta receptor type 3Imported |
Gene namesi | Name:Tgfbr3Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104637, Tgfbr3 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix Source: Ensembl
- extracellular space Source: Ensembl
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- inhibin-betaglycan-ActRII complex Source: Ensembl
- integral component of plasma membrane Source: Ensembl
Other locations
- cytoplasm Source: Ensembl
- receptor complex Source: Ensembl
Keywords - Cellular componenti
MembraneARBA annotation, SecretedARBA annotationInteractioni
GO - Molecular functioni
- fibroblast growth factor binding Source: Ensembl
- SMAD binding Source: Ensembl
- transforming growth factor beta binding Source: Ensembl
- type II transforming growth factor beta receptor binding Source: Ensembl
Family & Domainsi
Phylogenomic databases
GeneTreei | ENSGT00530000063861 |
OMAi | FRSPCEL |
OrthoDBi | 1263397at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom IPR017977, ZP_dom_CS |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
PRINTSi | PR00023, ZPELLUCIDA |
SMARTi | View protein in SMART SM00241, ZP, 1 hit |
PROSITEi | View protein in PROSITE PS00682, ZP_1, 1 hit PS51034, ZP_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0A0R4J097-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVTSHHMVP VFVLMSACLA TAGPEPSTRC ELSPISASHP VQALMESFTV
60 70 80 90 100
LSGCASRGTT GLPREVHILN LRSTDQGLGQ PQREVTLHLN PIASVHTHHK
110 120 130 140 150
PVVFLLNSPQ PLVWHVKTER LAAGVPRLFL VSEGSVVQFS SGNFSLTAET
160 170 180 190 200
EERSFPQENE HLLHWAQKEY GAVTSFTELK IARNIYIKVG EDQVFPPTCN
210 220 230 240 250
IGKNFLSLNY LAEYLQPKAA EGCVLASQPH EKEVHIIELI SPNSNPYSTF
260 270 280 290 300
QVDIIIDIRP AREDPEVVKN LVLILKCKKS VNWVIKSFDV KGNLKVIAPD
310 320 330 340 350
SIGFGKESER SMTVTKLVRN DIPSTQENLM KWALDNGYSP VTSYTIAPVA
360 370 380 390 400
NRFHLRLENN EEMRDEEVHT IPPELRILLG PDHLPALDSP SFQGEIPNGG
410 420 430 440 450
FPFPFPDIPR RGWKEGEDRI PRPKEPIIPR VQLLPDHREP EEVQGGVNIA
460 470 480 490 500
LSVKCDNEKM VVAVDKDSFQ TNGYSGMELT LLDPSCKAKM NGTHFVLESP
510 520 530 540 550
LNGCGTRHRR SAPDGVVYYN SIVVQAPSPG DSSGWPDGYE DLESGDNGFP
560 570 580 590 600
GDTDEGETAP LSRAGVVVFN CSLRQLRSPS GFQDQLDGNA TFNMELYNTD
610 620 630 640 650
LFLVPSPGVF SVAENEHVYV EVSVTKADQD LGFAIQTCFI SPYSNPDRMS
660 670 680 690 700
DYTIIENICP KDDSVKFYSS KRVHFPIPHA EVDKKRFSFV FKSVFNTSLL
710 720 730 740 750
FLHCELTLCS RKKGSQKLPK CVTPDDACTS LDATMIWTMM QNKKTFTKPL
760 770 780 790 800
AVVLQVDYKE NVPNMKESSP VPPPPQIFHG LDTLTVMGIA FAAFVIGALL
810 820 830 840 850
TGALWYIYSH TGETARRQQV PTSPPASENS SAAHSIGSTQ STPCSSSSTA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO88393 | TGBR3_MOUSE | Transforming growth factor beta rec... | Tgfbr3 | 850 | Annotation score: | ||
F6VPT9 | F6VPT9_MOUSE | Transforming growth factor beta rec... | Tgfbr3 | 156 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC133897 Genomic DNA No translation available. AC166776 Genomic DNA No translation available. |
RefSeqi | NP_035708.2, NM_011578.4 |
Genome annotation databases
Ensembli | ENSMUST00000031224; ENSMUSP00000031224; ENSMUSG00000029287 |
GeneIDi | 21814 |
KEGGi | mmu:21814 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC133897 Genomic DNA No translation available. AC166776 Genomic DNA No translation available. |
RefSeqi | NP_035708.2, NM_011578.4 |
3D structure databases
SMRi | A0A0R4J097 |
ModBasei | Search... |
Proteomic databases
EPDi | A0A0R4J097 |
Protocols and materials databases
Antibodypediai | 1634, 443 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000031224; ENSMUSP00000031224; ENSMUSG00000029287 |
GeneIDi | 21814 |
KEGGi | mmu:21814 |
Organism-specific databases
CTDi | 7049 |
MGIi | MGI:104637, Tgfbr3 |
Phylogenomic databases
GeneTreei | ENSGT00530000063861 |
OMAi | FRSPCEL |
OrthoDBi | 1263397at2759 |
Miscellaneous databases
BioGRID-ORCSi | 21814, 2 hits in 19 CRISPR screens |
ChiTaRSi | Tgfbr3, mouse |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom IPR017977, ZP_dom_CS |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
PRINTSi | PR00023, ZPELLUCIDA |
SMARTi | View protein in SMART SM00241, ZP, 1 hit |
PROSITEi | View protein in PROSITE PS00682, ZP_1, 1 hit PS51034, ZP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0R4J097_MOUSE | |
Accessioni | A0A0R4J097Primary (citable) accession number: A0A0R4J097 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 20, 2016 |
Last sequence update: | January 20, 2016 | |
Last modified: | December 2, 2020 | |
This is version 43 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |