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Entry version 33 (19 Jan 2022)
Sequence version 1 (20 Jan 2016)
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Protein
Submitted name:

F-box protein 11a

Gene

fbxo11a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri785 – 856UBR-typePROSITE-ProRule annotationAdd BLAST72

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-bindingARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-8951664, Neddylation
R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
F-box protein 11aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fbxo11aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-061103-70, fbxo11a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A0R4IXA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0R4IXA1, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000082532

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini105 – 151F-boxInterPro annotationAdd BLAST47
Domaini785 – 856UBR-typeInterPro annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 52DisorderedSequence analysisAdd BLAST52
Regioni65 – 85DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 33Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi68 – 82Polar residuesSequence analysisAdd BLAST15

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri785 – 856UBR-typePROSITE-ProRule annotationAdd BLAST72

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1777, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063425

Database of Orthologous Groups

More...
OrthoDBi
355502at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0A0R4IXA1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039448, Beta_helix
IPR006633, Carb-bd_sugar_hydrolysis-dom
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR029799, FBX11/DRE-1
IPR022441, Para_beta_helix_rpt-2
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence
IPR003126, Znf_UBR

The PANTHER Classification System

More...
PANTHERi
PTHR22990:SF20, PTHR22990:SF20, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13229, Beta_helix, 2 hits
PF12937, F-box-like, 1 hit
PF02207, zf-UBR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00722, CASH, 3 hits
SM00256, FBOX, 1 hit
SM00710, PbH1, 19 hits
SM00396, ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51126, SSF51126, 3 hits
SSF81383, SSF81383, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03804, para_beta_helix, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50181, FBOX, 1 hit
PS51157, ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A0R4IXA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSVRATNRR PRRVSRPRPV PPDRNNAERD EEVPAEMVAE ESGQGAQNSP
60 70 80 90 100
YQLRRKSLLP KRTACPTKTN MEGASTSTTE NFGHRAKRAR VSGKSQDLPV
110 120 130 140 150
TPAEQYLQVK LPDEVVLKIF SYLLEQDLCR AACVCKRFSE LANDPILWKR
160 170 180 190 200
LYMEVFEYTR PMMHPESGKF FQINPEEYEQ PNPWKESFQQ LYKGAHVKPG
210 220 230 240 250
FAEHFYSNPA RYKGRENMLY YDTIEDALGG VQEAHFDGLI FVHSGIYTDE
260 270 280 290 300
WIYIESPITM IGAAPGKVAD KVIIENTRDS TFVFMEGSED AYVGYMTIKF
310 320 330 340 350
NPDDKSAQHH NAHHCLEITV NCSPIIDHCI IRSTCTVGSA VCVSGQGASP
360 370 380 390 400
TIKHCNISDC ENVGLYITDH AQGIYEDNEI SNNALAGIWV KNHGNPIIRR
410 420 430 440 450
NHIHHGRDVG VFTFDHGMGY FESCNIHRNR IAGFEVKAYA NPTVVRCEIH
460 470 480 490 500
HGQTGGIYVH EKGRGQFIEN KIYANNFAGV WITSNSDPTI RGNAIFNGNQ
510 520 530 540 550
GGVYIFGDGR GLIEGNDIYG NALAGIQIRT NSCPIVRHNK IHDGQHGGIY
560 570 580 590 600
VHEKGQGVIE ENEVYSNTLA GVWVTTGSTP VLRRNRIHSG KQVGVYFYDN
610 620 630 640 650
GHGVLEDNDI YNHMYSGVQI RTGSNPKIRR NKIWGGQNGG ILVYNSGLGF
660 670 680 690 700
IEDNEIFDNA MAGVWIKTDS NPTLRRNKIH DGRDGGICIF NGGRGLLEEN
710 720 730 740 750
DIFRNAQAGV LISTNSHPVL RKNRIFDGFA AGIEITNHAT ATLEGNQIFN
760 770 780 790 800
NRFGGLFLAS GVNVTMKDNK IMNNQDAIEK AVSRGQCLYK ISSYTSYPMH
810 820 830 840 850
DFYRCHTCNT TDRNAICVNC IKKCHQGHDV EFIRHDRFFC DCGAGTLSNP
860 870
CTLAGEPTHD TDTLYDSAPP IESNTLQHN
Length:879
Mass (Da):98,268
Last modified:January 20, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA5FE55594368239
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3JA39U3JA39_DANRE
F-box protein 11a
fbxo11a
879Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IJR2A0A0R4IJR2_DANRE
F-box protein 11a
fbxo11a
844Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IL43A0A0R4IL43_DANRE
F-box protein 11a
fbxo11a
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QKG5A0A2R8QKG5_DANRE
F-box protein 11a
fbxo11a
858Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU463106 Genomic DNA No translation available.
CU468002 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005169611.1, XM_005169554.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000171765; ENSDARP00000140781; ENSDARG00000102294

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
777607

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU463106 Genomic DNA No translation available.
CU468002 Genomic DNA No translation available.
RefSeqiXP_005169611.1, XM_005169554.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000082532

Proteomic databases

PaxDbiA0A0R4IXA1

Genome annotation databases

EnsembliENSDART00000171765; ENSDARP00000140781; ENSDARG00000102294
GeneIDi777607

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
777607
ZFINiZDB-GENE-061103-70, fbxo11a

Phylogenomic databases

eggNOGiKOG1777, Eukaryota
GeneTreeiENSGT00530000063425
OrthoDBi355502at2759
PhylomeDBiA0A0R4IXA1

Enzyme and pathway databases

ReactomeiR-DRE-8951664, Neddylation
R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

ExpressionAtlasiA0A0R4IXA1, baseline and differential

Family and domain databases

Gene3Di2.160.20.10, 3 hits
InterProiView protein in InterPro
IPR039448, Beta_helix
IPR006633, Carb-bd_sugar_hydrolysis-dom
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR029799, FBX11/DRE-1
IPR022441, Para_beta_helix_rpt-2
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence
IPR003126, Znf_UBR
PANTHERiPTHR22990:SF20, PTHR22990:SF20, 1 hit
PfamiView protein in Pfam
PF13229, Beta_helix, 2 hits
PF12937, F-box-like, 1 hit
PF02207, zf-UBR, 1 hit
SMARTiView protein in SMART
SM00722, CASH, 3 hits
SM00256, FBOX, 1 hit
SM00710, PbH1, 19 hits
SM00396, ZnF_UBR1, 1 hit
SUPFAMiSSF51126, SSF51126, 3 hits
SSF81383, SSF81383, 1 hit
TIGRFAMsiTIGR03804, para_beta_helix, 4 hits
PROSITEiView protein in PROSITE
PS50181, FBOX, 1 hit
PS51157, ZF_UBR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0R4IXA1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0R4IXA1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: January 19, 2022
This is version 33 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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