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Entry version 24 (08 May 2019)
Sequence version 1 (20 Jan 2016)
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Protein
Submitted name:

Collagen, type V, alpha 3a

Gene

col5a3a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-1442490 Collagen degradation
R-DRE-1650814 Collagen biosynthesis and modifying enzymes
R-DRE-186797 Signaling by PDGF
R-DRE-2022090 Assembly of collagen fibrils and other multimeric structures
R-DRE-216083 Integrin cell surface interactions
R-DRE-3000171 Non-integrin membrane-ECM interactions
R-DRE-3000178 ECM proteoglycans
R-DRE-419037 NCAM1 interactions
R-DRE-8874081 MET activates PTK2 signaling
R-DRE-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type V, alpha 3aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:col5a3aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-968 col5a3a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500645179727 – 1887Sequence analysisAdd BLAST1861

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A0R4IW47

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000013036

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1658 – 1886Fibrillar collagen NC1InterPro annotationAdd BLAST229

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili452 – 472Sequence analysisAdd BLAST21
Coiled coili1622 – 1642Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154535

Identification of Orthologs from Complete Genome Data

More...
OMAi
AWNKEKP

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 3 hits

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0R4IW47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRLKETVFC AALLLLLTMC TLKTHAANVM DVLRALELSE DMEGVTVEAG
60 70 80 90 100
LCTERKGTSE TDMAYRIDKK IQLSAPTKQL FPDSAFPENF SLMTTVKAKR
110 120 130 140 150
NSQFFLLSLY DEQGVQQLGL EMGRSPVFLY EDHKGQPAPD LYPLFRKINL
160 170 180 190 200
SDGKWHRIAY SVEGKSVTLY LDCKKVQTLE LMRGDDPVVS TDGVIVFGTR
210 220 230 240 250
LLDEEVFEGE IQQLLLVDDP QAASDYCQDY IPDCDSPLPY SAQKLDPEEA
260 270 280 290 300
SLIHNLDDVM QGDEPVKPTK RSKKDRKGKK NKKRKGKKGK KESRKKKKEA
310 320 330 340 350
EALEEGFLEV SSKLPEYLAQ EPVRETTPAS TKLPDPPTTE QLKMPVESPT
360 370 380 390 400
IMIDLIDSIP DMPTHEPDTY QDSSPSTKPV TDLEDQAILA SAFSESPKQE
410 420 430 440 450
RPIKTPEVEE FSDDLYGDQH NVLSVSTVTV GPNITDYEVL EYEEFKNASD
460 470 480 490 500
SHELEYEEYE IYEERFDHAE RERPDTWGGE GVRFAKGQKG EPAVVEPGAV
510 520 530 540 550
FQGPPGPPGP QGLPGIPGIT GPPGPSGDPG DVGPEGRPGL PGADGIPGPP
560 570 580 590 600
GTMLMLPFHY GGDSQKGPMI SAQQAQAQAI LQQTKLSLKG PPGPLGLTGR
610 620 630 640 650
PGPVGLPGPS GLKGDIGENG PPGPRGLPGS AGPNGKPGKR GRSGADGGRG
660 670 680 690 700
APGETGAKGD RGFDGLPGLP GNKGHRGDRG KPGPQGPHGE PGHKGSDGPV
710 720 730 740 750
GPRGQPGEPG IRGLVGPRGP PGPPGQQGIQ GVDGVQGPKG NLGPLGEPGP
760 770 780 790 800
PGQQGNPGIQ GFPGPQGPIG LPGEKGPEGK PGMQGLPGID GPPGHPGREG
810 820 830 840 850
PPGEKGHQGL SGAQGPVGYP GPRGVKGADG VRGLKGSKGE KGEDGFPGAK
860 870 880 890 900
GEMGIKGDRG DNGSPGSRGE DGPEGPKGQS GPLGEPGSAG IAGEKGKLGV
910 920 930 940 950
PGLPGYPGRQ GSKGSVGFPG TAGLEGEKGK RGPAGQAGAD GERGPNGARG
960 970 980 990 1000
GRGARGPTGK PGAKGSAGHD GPPGATGERG PQGPQGRNGE AGPKGPNGPP
1010 1020 1030 1040 1050
GKDGLPGHPG QRGEPGFQGK TGPPGPAGVV GPQGKTGETG PTGDRGHPGA
1060 1070 1080 1090 1100
PGPPGEQGLP GAAGKEGTKG DPGPAGQPGK SGPAGRRGFR GERGLPGILG
1110 1120 1130 1140 1150
SSGLKGGEGP LGVAGPIGAT GERGSSGPAG AIGQPGRQGG VGPAGPMGEK
1160 1170 1180 1190 1200
GEPGEKGSIG PAGRDGEQGP VGLPGPAGPP GPPGDDGDKG ETGGPGQKGS
1210 1220 1230 1240 1250
KGDKGEGGPP GPPGSQGPAG QPGPPGLDGE PGLRGQQGMY GPKGDEGERG
1260 1270 1280 1290 1300
FKGATGPPGL QGMPGPPGEK GESGHVGSMG PPGQHGPRGP QGAIGGEGPQ
1310 1320 1330 1340 1350
GMPGAVGQPG VVGEKGEDGE AGNPGNVGET GLVGEKGEVG EKGDAGPPGA
1360 1370 1380 1390 1400
AGPPGIRGIP GSDGPKGNPG PLGFPGDSGP SGEPGVNGID GGPGAKGDNG
1410 1420 1430 1440 1450
EPGKSGPQGA SGEPGPPGPP GRRGHIGPEG KEGKQGKKGA KGSAGAEGPI
1460 1470 1480 1490 1500
GKTGPVGPQG HPGNPGPEGL RGIPGSAGEQ GLNGPPGQTG PPGPMGPAGL
1510 1520 1530 1540 1550
PGLKGDPGIK GDKGHGGLIG LIGPPGEMGE KGDRGLPGIQ GIQGTKGDGG
1560 1570 1580 1590 1600
AGGPPGPTGP PGPPGLSGAI GEKGSKGDQG AIGARGDTGP AGPPGPPGPP
1610 1620 1630 1640 1650
AAMIEPLPIR EGRKKRRRHS NRQGAESRAE AEEEEAVQLN MEDFLQADEA
1660 1670 1680 1690 1700
LDEPEGMEEV FASLNSMKTE VELMRKPLGT FESPARTCKE LMLCHPDYKD
1710 1720 1730 1740 1750
GEYWIDPNQG CHRDSIRVFC NFTAEGETCL HPDKRFETVK LAAWNKEKPG
1760 1770 1780 1790 1800
SWYSQYRKGK QFSYIDTEGN PVPVVQMTFL KLLSATAMQT FTFSCQNSIG
1810 1820 1830 1840 1850
WYDMSNHNHQ HALRFRGSND EEMTQDKSPF ITALYDGCQT RKGLDTTVLQ
1860 1870 1880
INSPRSELLP LIDVAISDFG SNNQKFGFHV GTVCFSG
Length:1,887
Mass (Da):191,484
Last modified:January 20, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8CE094E2EAE0459
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX544872 Genomic DNA No translation available.
BX936405 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000170461; ENSDARP00000141009; ENSDARG00000098294

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX544872 Genomic DNA No translation available.
BX936405 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000013036

Proteomic databases

PaxDbiA0A0R4IW47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000170461; ENSDARP00000141009; ENSDARG00000098294

Organism-specific databases

ZFINiZDB-GENE-030131-968 col5a3a

Phylogenomic databases

GeneTreeiENSGT00940000154535
OMAiAWNKEKP

Enzyme and pathway databases

ReactomeiR-DRE-1442490 Collagen degradation
R-DRE-1650814 Collagen biosynthesis and modifying enzymes
R-DRE-186797 Signaling by PDGF
R-DRE-2022090 Assembly of collagen fibrils and other multimeric structures
R-DRE-216083 Integrin cell surface interactions
R-DRE-3000171 Non-integrin membrane-ECM interactions
R-DRE-3000178 ECM proteoglycans
R-DRE-419037 NCAM1 interactions
R-DRE-8874081 MET activates PTK2 signaling
R-DRE-8948216 Collagen chain trimerization

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 3 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0R4IW47_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0R4IW47
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: May 8, 2019
This is version 24 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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