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Entry version 24 (05 Dec 2018)
Sequence version 1 (20 Jan 2016)
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Protein
Submitted name:

Persistent plexus

Gene

prp

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-1650814 Collagen biosynthesis and modifying enzymes
R-DRE-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Persistent plexusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prpImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-090826-1 prp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500645158528 – 1622Sequence analysisAdd BLAST1595

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A0R4IR54

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000098905

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 213VWFAInterPro annotationAdd BLAST176

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158212

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPGPHGQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 14 hits
PF00092 VWA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00210 TSPN, 1 hit
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0R4IR54-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFRFGLRIS LVLTVLALTL YGGGVEGQRA GCKNVHYDLV FILDTSSSVG
60 70 80 90 100
KENFEKIRQW VANLVESFDV GVDKTRVAVV RYSDRPTVEF NLARYKTLEE
110 120 130 140 150
VKRAAGNIRY LGGNTKTGDA ISFTTTNIFT ERAGARPAAK GIQKVAILLT
160 170 180 190 200
DGQSQDFVLE PSVAAAAAGI RLFAVGIGEA LKEELEEIAA EPKSAHVFHV
210 220 230 240 250
TDFDAIDKIR GRLRRRLCEN VLCPNMKVQA GRFRPNSTSA GLTEVPGFDL
260 270 280 290 300
MEFFNVRDFL GEKFEPGQTP YVRLGALPIV QKTEDVLPQG LPDEYAFVTT
310 320 330 340 350
FKFRKTSRKE DWYLWQVYDK YGIPQVSIRL DGENRAVEYN AVGLTKDAVR
360 370 380 390 400
AVFRNPEVDN LFDRNWHKIG MRVDSKSVSL FLDCKHIETL PIEEREDIDI
410 420 430 440 450
QGKTVIGKRL YDSVPIDFDL QRMVIYCDGK QSEQETCCDI PGGLCEQTLV
460 470 480 490 500
TEAPPVPLPT PKPTSAEQKK PAAANCSCPA GERGDTGLPG APGPKGEKGD
510 520 530 540 550
PGLKGAEGPP GLKGLKGERG QAVSIKGDRG EKGDSGEFGE PGLTGDRGEK
560 570 580 590 600
GSDGLPGLAG KKGDKGERGD QGVAGEAGLP GPLGPKKFQA NIKEAGCPGV
610 620 630 640 650
RSSQGGAGNK GEKGSTGDQG ERGADGFPGK PGLPGKEGVR GLIGAPGPNG
660 670 680 690 700
VKGEKGAQGP AGIPGDAIQL AGLKGETGAQ GEAGLPGVDG LPGPPGPPGP
710 720 730 740 750
PGLPGETGDT GPRGKKGDAG LPGVDGLPGP PGPQGPPGVS GSPGQTGPPG
760 770 780 790 800
LPGEIGFSGK PGESGKPGSP GKDGADGFPG NDGEKGQKGE SGQDGFPGKP
810 820 830 840 850
GPKGDEGPPG PRGPPGERGE SGLTGQVGPM GPKGERGNHG ERGREGLSGA
860 870 880 890 900
KGEKGDKGEI GPRGPAGAPG NVANVIPEPG EPGKPGEKGE KGDQGKPGDM
910 920 930 940 950
GQRGLPGEQG FRGQPGPVGP KGDAGDKGEP GRHGDPGPPG LMGPQGSRGL
960 970 980 990 1000
PGNVGIPGSI GPPGIAGQKG DKGDGGKDGP PGPPGPTGEP GLRGEIGLPG
1010 1020 1030 1040 1050
KGKEGEKGDA GPPGIAGPPG LRGLPGNQGM QGMPGNRGPP GEGSPGSQGP
1060 1070 1080 1090 1100
PGPAGPPGAA GLRGPPGVAG VQGPAGHNGI PGRPGEKGSP GEPGKAADLS
1110 1120 1130 1140 1150
DLNLKGVCSD CPAGPPGQPG IPGPPGDKGH SGPPGKNGQD GYAGAPGPTG
1160 1170 1180 1190 1200
PAGPPGSDGA KGVKGDRGPA GTPGDKGEKG APGPPGYPGA AGAMGQPGND
1210 1220 1230 1240 1250
GNPGPVGTPG PPGEKGKEGM TGIQGPPGLP GLMGMMGKPG KDGRPGESGE
1260 1270 1280 1290 1300
PGKQGEPGQP GRDGLRGMPG FKGHRGEPGP PGSKGEEGKQ GVPGREGQPG
1310 1320 1330 1340 1350
KDGNSGPPGP EGMRGPRGES GQPGEQGPTG KPGSQGNPGQ PGHKGEAGSP
1360 1370 1380 1390 1400
GLPGFPGPKG PSGPPGPIGP EGKQGMLGKA GDRGQKGEKG DNGIKGDKGP
1410 1420 1430 1440 1450
VGDPGIPGNP GSPGRKGHTG MMGMSGPPGE VGPAGPPGTP GIPGLPGLRG
1460 1470 1480 1490 1500
ETPSLEQMRR LIQDELSKQL DAKLAYLMAQ MQPAHIKSTA GRPGPPGPPG
1510 1520 1530 1540 1550
KDGSPGRQGP TGEPGMPGQN GVEGLRGPAG PKGERGSKGE KGEDGVGQRG
1560 1570 1580 1590 1600
EPGPIGPMGP AGMPGDGKDG LPGAAGAQGE PGNPGPHGQP GPPGPTGQCD
1610 1620
PSQCAYYASL ASRPHTKNVK GT
Length:1,622
Mass (Da):161,883
Last modified:January 20, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2D3CDFAECCE66F2
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000168576; ENSDARP00000138598; ENSDARG00000101592

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000098905

Proteomic databases

PaxDbiA0A0R4IR54

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000168576; ENSDARP00000138598; ENSDARG00000101592

Organism-specific databases

ZFINiZDB-GENE-090826-1 prp

Phylogenomic databases

GeneTreeiENSGT00940000158212
OMAiNPGPHGQ

Enzyme and pathway databases

ReactomeiR-DRE-1650814 Collagen biosynthesis and modifying enzymes
R-DRE-8948216 Collagen chain trimerization

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 14 hits
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00210 TSPN, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0R4IR54_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0R4IR54
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: December 5, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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