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UniProtKB - A0A0R4IQG1 (A0A0R4IQG1_DANRE)
Protein
3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene
hmgcs1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
UniRule annotationCatalytic activityi
: (R)-mevalonate biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.UniRule annotationARBA annotation This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.
GO - Molecular functioni
- hydroxymethylglutaryl-CoA synthase activity Source: GO_Central
GO - Biological processi
- acetyl-CoA metabolic process Source: GO_Central
- cholesterol biosynthetic process Source: UniProtKB-KW
- embryonic viscerocranium morphogenesis Source: ZFIN
- erythrocyte development Source: ZFIN
- farnesyl diphosphate biosynthetic process, mevalonate pathway Source: GO_Central
- neural crest cell differentiation Source: ZFIN
- oligodendrocyte development Source: ZFIN
Keywordsi
Molecular function | TransferaseUniRule annotation |
Biological process | Cholesterol biosynthesisARBA annotation, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Enzyme and pathway databases
Reactomei | R-DRE-191273, Cholesterol biosynthesis R-DRE-77111, Synthesis of Ketone Bodies |
UniPathwayi | UPA00058;UER00102 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-hydroxy-3-methylglutaryl coenzyme A synthaseUniRule annotationARBA annotation (EC:2.3.3.10UniRule annotationARBA annotation)Short name: HMG-CoA synthaseUniRule annotation |
Gene namesi | Name:hmgcs1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040426-1042, hmgcs1 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 186 | HMG_CoA_synt_NInterPro annotationAdd BLAST | 174 | |
Domaini | 188 – 470 | HMG_CoA_synt_CInterPro annotationAdd BLAST | 283 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1393, Eukaryota |
GeneTreei | ENSGT00390000006096 |
OMAi | DDAYNWI |
OrthoDBi | 495111at2759 |
Family and domain databases
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR000590, HMG_CoA_synt_AS IPR013746, HMG_CoA_synt_C_dom IPR013528, HMG_CoA_synth_N IPR010122, HMG_CoA_synthase_euk IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF08540, HMG_CoA_synt_C, 1 hit PF01154, HMG_CoA_synt_N, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01833, HMG-CoA-S_euk, 1 hit |
PROSITEi | View protein in PROSITE PS01226, HMG_COA_SYNTHASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A0A0R4IQG1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGSLPAICE SMWPKDVGII AMEVYVPSQY VDQAELEEYD GVGAGKYTVG
60 70 80 90 100
LGQARMGFCS DREDINSLCL TVVQRLMERN GLSYESVGRL EVGTETIIDK
110 120 130 140 150
SKSTKTVLMQ LFEESGNTDV EGVDTTNACY GGTAALFNAV NWVESSSWDG
160 170 180 190 200
RYALVVAGDI AVYATGSARP TGGAGAVAML VGPNAPLAFE RGLRGTHMQH
210 220 230 240 250
AYDFYKPDMV SEYPVVDGKL SIQCYLSALD QCYSVYKNKI HARWQREGTE
260 270 280 290 300
GRCSLEDFGF MVFHSPYCKL VQKSLARLML NDFLCHPSPN MESGPFSGLE
310 320 330 340 350
AFRDVKIEDT YFDRDVEKAF MKASSELFDD KTKASLLISN QNGNMYTPSV
360 370 380 390 400
YGCLASVLAQ HTPQQLAGQR IGVFSYGSGF AATLYSIKVT QDGTPGSALD
410 420 430 440 450
KLVSSLCDLP ARLDSRQKVS PGVFAETMKL REETHHLANY IPQGSVDELF
460 470 480 490 500
PGTWYLTRVD EKHRRQYARR SMNDDRPLEA GLVSSSMAAE HIPSPLKKMP
510
RIPTTTAGPE VVVMSNGDH
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YJ34 | A0A0J9YJ34_DANRE | 3-hydroxy-3-methylglutaryl coenzyme... | hmgcs1 | 283 | Annotation score: | ||
A0A0R4IJE0 | A0A0R4IJE0_DANRE | 3-hydroxy-3-methylglutaryl coenzyme... | hmgcs1 | 201 | Annotation score: | ||
A0A0R4IME3 | A0A0R4IME3_DANRE | 3-hydroxy-3-methylglutaryl-CoA synt... | hmgcs1 | 141 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX322605 Genomic DNA No translation available. |
RefSeqi | XP_005155548.1, XM_005155491.2 |
Genome annotation databases
Ensembli | ENSDART00000167613; ENSDARP00000137373; ENSDARG00000103025 ENSDART00000190025; ENSDARP00000145051; ENSDARG00000103025 |
GeneIDi | 394060 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX322605 Genomic DNA No translation available. |
RefSeqi | XP_005155548.1, XM_005155491.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000121903 |
Proteomic databases
PaxDbi | A0A0R4IQG1 |
Genome annotation databases
Ensembli | ENSDART00000167613; ENSDARP00000137373; ENSDARG00000103025 ENSDART00000190025; ENSDARP00000145051; ENSDARG00000103025 |
GeneIDi | 394060 |
Organism-specific databases
CTDi | 3157 |
ZFINi | ZDB-GENE-040426-1042, hmgcs1 |
Phylogenomic databases
eggNOGi | KOG1393, Eukaryota |
GeneTreei | ENSGT00390000006096 |
OMAi | DDAYNWI |
OrthoDBi | 495111at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00058;UER00102 |
Reactomei | R-DRE-191273, Cholesterol biosynthesis R-DRE-77111, Synthesis of Ketone Bodies |
Family and domain databases
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR000590, HMG_CoA_synt_AS IPR013746, HMG_CoA_synt_C_dom IPR013528, HMG_CoA_synth_N IPR010122, HMG_CoA_synthase_euk IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF08540, HMG_CoA_synt_C, 1 hit PF01154, HMG_CoA_synt_N, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01833, HMG-CoA-S_euk, 1 hit |
PROSITEi | View protein in PROSITE PS01226, HMG_COA_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0R4IQG1_DANRE | |
Accessioni | A0A0R4IQG1Primary (citable) accession number: A0A0R4IQG1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 20, 2016 |
Last sequence update: | January 20, 2016 | |
Last modified: | January 19, 2022 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |