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Entry version 28 (29 Sep 2021)
Sequence version 2 (20 Jun 2018)
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Protein

Transient receptor potential cation channel subfamily M member 2

Gene

trpm2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonselective, voltage-independent cation channel that mediates Ca2+ influx, leading to increased cytoplasmic Ca2+ levels. Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic N-terminal region causes a conformation change; the channel is primed but still requires Ca2+ binding to trigger channel opening.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei267ADP-ribose1 Publication1
Binding sitei274ADP-ribose1 Publication1
Binding sitei330ADP-ribose1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi853Calcium1 Publication1
Metal bindingi856Calcium1 Publication1
Metal bindingi879Calcium1 Publication1
Metal bindingi1084Calcium1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-3295583, TRP channels
R-DRE-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trpm2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-061214-4, trpm2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 725CytoplasmicCuratedAdd BLAST725
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei726 – 7381 PublicationAdd BLAST13
Topological domaini739 – 808CytoplasmicCuratedAdd BLAST70
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei809 – 829Helical1 PublicationAdd BLAST21
Topological domaini830 – 836ExtracellularCurated7
Transmembranei837 – 857Helical1 PublicationAdd BLAST21
Topological domaini858 – 876CytoplasmicCuratedAdd BLAST19
Transmembranei877 – 897Helical1 PublicationAdd BLAST21
Topological domaini898 – 905ExtracellularCurated8
Transmembranei906 – 926Helical1 PublicationAdd BLAST21
Topological domaini927 – 941CytoplasmicCuratedAdd BLAST15
Transmembranei942 – 968Helical1 PublicationAdd BLAST27
Topological domaini969 – 977ExtracellularCurated9
Intramembranei978 – 1002Pore-forming1 PublicationAdd BLAST25
Topological domaini1003 – 1034ExtracellularCuratedAdd BLAST32
Transmembranei1035 – 1059Helical1 PublicationAdd BLAST25
Topological domaini1060 – 1087CytoplasmicCuratedAdd BLAST28
Intramembranei1088 – 11051 PublicationAdd BLAST18
Topological domaini1106 – 1470CytoplasmicCuratedAdd BLAST365

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi150K → A: No significant effect on channel activity. 1 Publication1
Mutagenesisi267Y → A: Decreased channel activity. 1 Publication1
Mutagenesisi270E → A: Decreased channel activity. 1 Publication1
Mutagenesisi274R → A: Decreased channel activity. Loss of channel activity; when associated with A-330. 1 Publication1
Mutagenesisi330R → A: Decreased channel activity. Loss of channel activity; when associated with A-274. 1 Publication1
Mutagenesisi1157 – 1470Missing : Loss of channel activity. 1 PublicationAdd BLAST314

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004463721 – 1470Transient receptor potential cation channel subfamily M member 2Add BLAST1470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1008 ↔ 1020Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1011N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11470
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0R4IMY7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni305 – 308ADP-ribose binding1 Publication4
Regioni1157 – 1470Divergent Nudix hydrolase-like domain1 PublicationAdd BLAST314
Regioni1215 – 1256DisorderedSequence analysisAdd BLAST42
Regioni1281 – 1314DisorderedSequence analysisAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi991 – 993Selectivity filter1 Publication3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1224 – 1248Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds ADP-ribose via the N-terminal cytoplasmic region (PubMed:30250252). Other family members contain a C-terminal Nudix hydrolase domain that binds ADP-ribose and is important for channel gating. In zebrafish, the corresponding region is highly divergent and has only low affinity for ADP-ribose (PubMed:30467180). Still, the region is required for channel activity (PubMed:30250252).2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156404

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821, Ion_trans_dom
IPR015797, NUDIX_hydrolase-like_dom_sf
IPR029594, TRPM2
IPR041491, TRPM_SLOG

The PANTHER Classification System

More...
PANTHERi
PTHR13800:SF2, PTHR13800:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 1 hit
PF18139, LSDAT_euk, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55811, SSF55811, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A0R4IMY7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEAALEPTL VQTLAVSTAK GGRYLSLSPS FQRCSLASWI KENIKKKECC
60 70 80 90 100
FYVEDGREGI CKCGYPKVQH CDEAIKPEDY MGEQWDKHRH VRETPTDAFG
110 120 130 140 150
DISFGGLGQK TGKYVRVSSD TSCENLYQLM TEQWKLRSPN LLISVTGGAK
160 170 180 190 200
NFYIKTHLKD KFRRGLIKVA QTTGAWILTG GTHAGVMKHV GMAVRDYTLS
210 220 230 240 250
SGSMEGQIVV IGVAPWGVIH NRSTLIHPEG RFPAYYSLDE QGQGRLSCLD
260 270 280 290 300
INHTHFLLVD DGTQGHYGVE IELRARLEKL ISKLSLGNRE SGVTIPVVCV
310 320 330 340 350
VLDGGPGTLN TIYNSMLNHT PCVVLEGSGR LADVIAHVAS VPVSKVTMAL
360 370 380 390 400
INRLLKRFFM QEYKNFTELQ IIEWTKKIQD ILRMPHLLTV FRIDEDKNYD
410 420 430 440 450
VDVAILQALL KASRSDEHAG RHCWERQLEL AVAWNRVDIA ESEIFTEESQ
460 470 480 490 500
WTSSDLHPAM FSALVGDKPE FVRLLLENGV CVREFLEREE TLCELYSHLP
510 520 530 540 550
SCFFLRKLAK RVQGGKMRRG QEPLPGSRKV CLSHVSEEVR HLLGSFTQPL
560 570 580 590 600
YIASRYKPTK DDVRLKVPSK GALDLPCSGE EWSADTVWDP GRDLFLWAVV
610 620 630 640 650
QNNRELAEIG WEQCRDCIAA ALAASKILRK LAQESGEDDS EEATEMLELA
660 670 680 690 700
NHYEKQAIGV FSECHSWDAQ RAQKLLIRIS PSWGRSTCLW LALEAHDKSF
710 720 730 740 750
IAHSGVQALL TQIWCGELSV DNPHWKVLLC MIFFPLIYTG FLTFRRDEDI
760 770 780 790 800
QRQAERTEQQ KLAMESVFAG QSDGKIKRHL RGFSQKSELK PLNCSSRLMS
810 820 830 840 850
FLKSPQVKFY WNIASYFGFL WLFAVVLMID FQTSPSWREL LLYVWLTSLV
860 870 880 890 900
CEEIRQLYHD FDGSGFRRKA KMYIKDLWNI LDVLSIVLFI AGLICRLQAS
910 920 930 940 950
DTVFYIGKVI LCIDFIIFCL RLMAIFSISR TLGPKIIIVR RMMLDLFFFM
960 970 980 990 1000
FLLSIWVVAY GVAKQGILIE NEERLNWIIR GAVYEPYITI FGNFPTNIDN
1010 1020 1030 1040 1050
TLFDISSCSV NASDPLKPKC PMLNADNTPV FPEWLTIMML CVYLLFANIL
1060 1070 1080 1090 1100
LLNLLIAIFN YTFQEVQDNT DTIWKFQRYE LIKEYHSRPA LPPPFILLSH
1110 1120 1130 1140 1150
LILFIRGVFL RDLPQRHKNF RQELEQTEEE ELLSWEAYMK DNYLASTRQD
1160 1170 1180 1190 1200
ESQSVEHRIH DTAEKVGAMS ELLEREQEMV SATMAKRLAR LEEQVSESAK
1210 1220 1230 1240 1250
ALRWIIDALK SQGCKSKVQP PLMRSKSSDR DDGDSSGQET DDEEAPHMFA
1260 1270 1280 1290 1300
RQLQYPDSTV RRFPVPEEKV SWEVNFSPYQ PPVYNQQDSS ESDTSALDKH
1310 1320 1330 1340 1350
RNPGGRTGIR GKGALNTLGP NHILHPIFTR WRDAEHKVLE FLAVWEDAEK
1360 1370 1380 1390 1400
RWALLGGPAQ PDEPLAQVLE RILGKKLNEK TKTLLKAGEE VYKGYVDDSR
1410 1420 1430 1440 1450
NTDNAWVETS IITLHCDKNT PLMADLNHMV ESSLSSHQPL QWREVSSDAC
1460 1470
RCSYQREALR QIAHHHNTYF
Length:1,470
Mass (Da):167,987
Last modified:June 20, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96E3253B800F205B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5H1ZRI9A0A5H1ZRI9_DANRE
Transient receptor potential cation...
trpm2
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6NMI9F6NMI9_DANRE
Transient receptor potential cation...
trpm2
1,078Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0S5A1B0S5A1_DANRE
Transient receptor potential cation...
trpm2
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4INU4A0A0R4INU4_DANRE
Transient receptor potential cation...
trpm2
656Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR753902 Genomic DNA No translation available.
CU855885 Genomic DNA No translation available.
FQ311915 Genomic DNA No translation available.
FQ377657 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000166906; ENSDARP00000136274; ENSDARG00000101641

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR753902 Genomic DNA No translation available.
CU855885 Genomic DNA No translation available.
FQ311915 Genomic DNA No translation available.
FQ377657 Genomic DNA No translation available.

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6DRJelectron microscopy3.30A/B/C/D1-1470[»]
6DRKelectron microscopy3.80A/B/C/D1-1470[»]
6PKVelectron microscopy4.30A/B/C/D32-1470[»]
6PKWelectron microscopy4.50A/B/C/D32-1470[»]
6PKXelectron microscopy4.20A/B/C/D32-1470[»]
SMRiA0A0R4IMY7
ModBaseiSearch...
PDBe-KBiSearch...

Genome annotation databases

EnsembliENSDART00000166906; ENSDARP00000136274; ENSDARG00000101641

Organism-specific databases

ZFINiZDB-GENE-061214-4, trpm2

Phylogenomic databases

GeneTreeiENSGT00940000156404

Enzyme and pathway databases

ReactomeiR-DRE-3295583, TRP channels
R-DRE-6798695, Neutrophil degranulation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A0A0R4IMY7

Family and domain databases

InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR015797, NUDIX_hydrolase-like_dom_sf
IPR029594, TRPM2
IPR041491, TRPM_SLOG
PANTHERiPTHR13800:SF2, PTHR13800:SF2, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 1 hit
PF18139, LSDAT_euk, 1 hit
SUPFAMiSSF55811, SSF55811, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0R4IMY7
Secondary accession number(s): A0A0R4IF00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 13, 2019
Last sequence update: June 20, 2018
Last modified: September 29, 2021
This is version 28 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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