Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 25 (11 Dec 2019)
Sequence version 1 (20 Jan 2016)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Nipped-B protein

Gene

nipbla

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycleUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nipped-B proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nipblaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060526-121 nipbla

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1805 – 1985Nipped-B_CInterPro annotationAdd BLAST181

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni131 – 211DisorderedSequence analysisAdd BLAST81
Regioni240 – 289DisorderedSequence analysisAdd BLAST50
Regioni332 – 503DisorderedSequence analysisAdd BLAST172
Regioni570 – 604DisorderedSequence analysisAdd BLAST35
Regioni629 – 708DisorderedSequence analysisAdd BLAST80
Regioni2005 – 2096DisorderedSequence analysisAdd BLAST92
Regioni2229 – 2272DisorderedSequence analysisAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1764 – 1791Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi131 – 162PolarSequence analysisAdd BLAST32
Compositional biasi258 – 280PolyampholyteSequence analysisAdd BLAST23
Compositional biasi332 – 366PolyampholyteSequence analysisAdd BLAST35
Compositional biasi447 – 484PolyampholyteSequence analysisAdd BLAST38
Compositional biasi629 – 693PolyampholyteSequence analysisAdd BLAST65
Compositional biasi2006 – 2022BasicSequence analysisAdd BLAST17
Compositional biasi2069 – 2087PolyampholyteSequence analysisAdd BLAST19
Compositional biasi2254 – 2270PolyampholyteSequence analysisAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SCC2/Nipped-B family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatUniRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010427

KEGG Orthology (KO)

More...
KOi
K06672

Identification of Orthologs from Complete Genome Data

More...
OMAi
SANFKDR

Database of Orthologous Groups

More...
OrthoDBi
7137at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026003 Cohesin_HEAT
IPR024986 Nipped-B_C
IPR033031 SCC2/Nipped-B

The PANTHER Classification System

More...
PANTHERi
PTHR21704 PTHR21704, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12765 Cohesin_HEAT, 1 hit
PF12830 Nipped-B_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A0R4IGM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGDMPHVPI TTLAGIAGLT DLLNQLPLPS PLPGTTTKSL LYNGRVAEDV
60 70 80 90 100
GHLLGCRDET LVSQLANSLS QVSTEHIELK DSLGSDELEG DVPVLLQLLM
110 120 130 140 150
SRNPNIFRNK TAPNTPQYPA QAGISQQSMA PPYKITHGSM QGSPASANYQ
160 170 180 190 200
QASMSHSPSG HFVPGQSGPG GRFLPQQGSP VPSPYAPQSP ATGYRQYPHP
210 220 230 240 250
PAYSQHQHLQ QGSVASPMIP GAMRNVHENK DQMRMGFTSH LLQSSPPYTP
260 270 280 290 300
PCDGTKDLHL GSQDKQRGQK SSEGEQDSPD KATVYDIVGS PAKDHTKLIL
310 320 330 340 350
RPSRARPAEV ELGGMYPGSD PEGELVEALA AIERMESEAA METERSAKEV
360 370 380 390 400
QDKDKPLKKR KQDSHPQEPG AAGTAGSGSG AQGGGGGANA GHRLAPQEAS
410 420 430 440 450
AAGTSASRPG LQVSLEQAGR VEDDCMGMPI PASEAQRWPQ EPQEGVTPKA
460 470 480 490 500
VKHEHDHDPE HPHYDDKQPD TPRQKHRPEG RHGDGGAQRA AVQSGSKQVE
510 520 530 540 550
LPPYMLGENT GVLKNFTIPK IRKGELGGGD IPEGWKQPCV RLERLEADVD
560 570 580 590 600
VKKSVKPVVV LQKLSIDEVQ RLMRERDSRA SKSGKNRLSS GRSGKGGIDP
610 620 630 640 650
SVLKDLPPEL LAEIESTMPL CERVKMNKRK RSTVNERPKY AEDSSEDEEF
660 670 680 690 700
SSRKRQRKDR DRTWEAEERD RRSSGEHRRG NFDARRGSGS RYDDSDQDSP
710 720 730 740 750
PPSLNEVARR LKMKQKKRKV YEPKLTPEEM MDSSTFKRFT LSIDNILENL
760 770 780 790 800
EDVDFTAQDD DEIPQELLLG KQQLNELGSE SAKIKAMGIT SRIPSDKLVK
810 820 830 840 850
LLNILEKNIL DGASLSTLMN LDNEGEDEER LWRDLIMERV TKSADACLTA
860 870 880 890 900
LNIMTSTHMP KAVYIEDVIE RVLQYTKFHL QNTLYPQYDP VYRVNPKGGS
910 920 930 940 950
MLSSRAKRAK CSTAKQKVII MLYNKVCDVV SNISELLEIQ LMTDTTILQV
960 970 980 990 1000
SSMGITPFFV ENVSELQLCA IKLVTAVFSR YEKHRQLILE EIFTSLARLP
1010 1020 1030 1040 1050
TSKRSLRNFR LNSSDDEGEP IYIQMVSALV LQLIQCVVHL PADRDSEDDH
1060 1070 1080 1090 1100
KKVDDDVFIT NSYETARRTA QNFLSVFLKK CGSKQGEEDY RPLFENFVQD
1110 1120 1130 1140 1150
LLSTVNKPDW PASELLLSLL GRLLVHQFSN KQTEMALRVA SLDYLGTVAA
1160 1170 1180 1190 1200
RLRKDSVTSR MDQKAIERII RENTEGDETQ RLQKALLDYM DENAETDPAL
1210 1220 1230 1240 1250
AFARKFYIAQ WFRDCTTETE KAMRSQNQKE DDSDGAQHAK ELQATGDIMQ
1260 1270 1280 1290 1300
RAETRKKFLH SVVKSTPNQF TTLRMNSDTV DYDDACLIVR YLASTRPFSQ
1310 1320 1330 1340 1350
SFDIYLTQIL RVLGESAIAV RTKAMKCLSE VVAVDPSILA RSDMQRGVHG
1360 1370 1380 1390 1400
RLMDNSTSVR EAAVELLGRF VLSRPQLTEQ YYDMLIERIL DTGISVRKRV
1410 1420 1430 1440 1450
IKILRDICLE QPNFSKITEM CVKMIRRVND EEGIKKLVNE TFQKLWFTPT
1460 1470 1480 1490 1500
PNHDKETMNR KILNITDVVS ACKDTGYDWF EQLLQNLLKS EEDSSYKPTR
1510 1520 1530 1540 1550
KACVQLVDNL VEHILKYEEA LAEHKSVNST RLVACITTLY LFSKIRAQLM
1560 1570 1580 1590 1600
VKHAMTMQPY LTTKCSSQSD FMVICNVAKI LELVVPLMDH PSESFLTTIE
1610 1620 1630 1640 1650
EDLMKLILKY GMTVVQYCVS CLGAIVNKVT HNYKFVWACF NRYYGALTKL
1660 1670 1680 1690 1700
KVQHQEGTNS MALAATKAAL LRSLFTAGAL CRHFDFDLEQ FKGTTKVVIK
1710 1720 1730 1740 1750
EKVLELLLYF TNHEDEEVKC KAIIGLGFLF IMHPSQMFVP EVKTLYNGLL
1760 1770 1780 1790 1800
SDKRSSITLK IQVLKNLQMY LQEEDTRMQE ADREWQKLSK QEDLKEMGDI
1810 1820 1830 1840 1850
SSGMSSSIMQ LYLKQVLESF FHAQSSVRHF ALNVIALTLS QGLIHPVQCV
1860 1870 1880 1890 1900
PYLIAMGTDA EPTMRNKADQ QLVEIDKKYT GFIHMKAVAG MKMSYQVQQA
1910 1920 1930 1940 1950
VFGSAGSVIR GFRQDESNSA QCSHLYSMVR ANRQHRRAFL ISLLNLFDDS
1960 1970 1980 1990 2000
SKMEVNMLLF IADNLAYFPY QSQEEPLFIM HHIDITLSVS GSNLLQTFKE
2010 2020 2030 2040 2050
SLVKIPGRKS RKRRRRRRRP QRQQPPPPPP QQQQQQQNGS EEERGAQDEE
2060 2070 2080 2090 2100
RERHSGDEEY DDDDYEEDED GHRVRKPKPT EDIRQSESDS DSDLDDVDAV
2110 2120 2130 2140 2150
MERLPDDSTS LVDFARASQG ILLLLVLKQH LKNLYGFSDG KIQKYSPSES
2160 2170 2180 2190 2200
AKVYDKAVNR KTLANFNPQQ TIDFLRHHDV HGELTYELKR KIVKQFLDFK
2210 2220 2230 2240 2250
LLMEHLDPDE EDEDGDTSAN VRNKAITALL GGAAASPRNH HTGDSEEDDE
2260 2270 2280 2290 2300
RSEGEERTPG ASRRGRRTGD SADLLSANMN ESVSALDIIA IHCPKYRDRP
2310 2320 2330 2340 2350
QIARVIQKNS DGYSIHWMAG SYSSTWAEAK KRDGRKLVPW VDSIKETDII
2360 2370 2380
YKKITLTSGN KLNHKVAQTL RSLYAAKDRN SS
Length:2,382
Mass (Da):268,283
Last modified:January 20, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9ED977C0D2020032
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5HSE3NIPLA_DANRE
Nipped-B-like protein A
nipbla
2,381Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU928047 Genomic DNA No translation available.
FP016143 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_009299463.1, XM_009301188.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000158447; ENSDARP00000132739; ENSDARG00000098272

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
570900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:570900

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928047 Genomic DNA No translation available.
FP016143 Genomic DNA No translation available.
RefSeqiXP_009299463.1, XM_009301188.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000158447; ENSDARP00000132739; ENSDARG00000098272
GeneIDi570900
KEGGidre:570900

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
570900
ZFINiZDB-GENE-060526-121 nipbla

Phylogenomic databases

GeneTreeiENSGT00390000010427
KOiK06672
OMAiSANFKDR
OrthoDBi7137at2759

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026003 Cohesin_HEAT
IPR024986 Nipped-B_C
IPR033031 SCC2/Nipped-B
PANTHERiPTHR21704 PTHR21704, 1 hit
PfamiView protein in Pfam
PF12765 Cohesin_HEAT, 1 hit
PF12830 Nipped-B_C, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0R4IGM2_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0R4IGM2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: December 11, 2019
This is version 25 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again