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Entry version 36 (25 May 2022)
Sequence version 1 (20 Jan 2016)
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Protein
Submitted name:

TRAF2 and NCK-interacting kinase a

Gene

tnika

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei54ATPPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-2559580, Oxidative Stress Induced Senescence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TRAF2 and NCK-interacting kinase a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tnikaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-3767, tnika

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0R4IEP9, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
A0A0R4IEP9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0R4IEP9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 289Protein kinaseInterPro annotationAdd BLAST265
Domaini1019 – 1306CNHInterPro annotationAdd BLAST288

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni308 – 345DisorderedSequence analysisAdd BLAST38
Regioni407 – 432DisorderedSequence analysisAdd BLAST26
Regioni520 – 933DisorderedSequence analysisAdd BLAST414

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi321 – 335Acidic residuesSequence analysisAdd BLAST15
Compositional biasi563 – 577Polar residuesSequence analysisAdd BLAST15
Compositional biasi597 – 639Polar residuesSequence analysisAdd BLAST43
Compositional biasi650 – 666Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi675 – 777Polar residuesSequence analysisAdd BLAST103
Compositional biasi799 – 815Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi851 – 871Polar residuesSequence analysisAdd BLAST21
Compositional biasi872 – 896Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi912 – 932Polar residuesSequence analysisAdd BLAST21

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183196

Database of Orthologous Groups

More...
OrthoDBi
533537at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001180, CNH_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00780, CNH, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00036, CNH, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50219, CNH, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A0R4IEP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASDSPARSL DEIDLSTLRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL
60 70 80 90 100
AAIKCMDVTG EEEEEIKAEI NMLKKYSHHR NIATYYGAFI KKNPPGVDDQ
110 120 130 140 150
LWLVMEFCGA GSVTDLIKNT KGNSLKEDWT AYISREILRG LTHLHQHKVI
160 170 180 190 200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVSRRNTFIG TPYWMAPEVI
210 220 230 240 250
ACDENPDATY DYKSDLWSLG ITALEMAEGA PPLCELHPMR ALFLIPRNAP
260 270 280 290 300
PRLKSKKWTK RFHSFIESCL VKNHNMRPGT DQLLKHPFIR DMANERTIRI
310 320 330 340 350
QLKDHIDRTR KKRGERDETE YEYSGSEEEE EAMLEIGEPS SIINIPGEST
360 370 380 390 400
LRRDFLRLQV ANKERSDALR RQQLEQQQNE GHKHQLLAER QKRIEEQKEQ
410 420 430 440 450
RRRLEEQQRR EREARKQQEQ RHRYEELRRE EERRQAEREQ EYIRRQLEEE
460 470 480 490 500
QRQLEILQQQ LLQEQALLLE YKRKQVEEQR QADRLQRQLQ QERAYLVSLQ
510 520 530 540 550
QQQQQQQQDS RPEEKKQLYH YKDAVNPSDK PAWAKKVEER SKLNRQSSPA
560 570 580 590 600
LQHKVANRIS DPSLPPRSES FSSGGMQPAR TPPMHRPVEP QMAHLVPVRS
610 620 630 640 650
HSSSMSVSQS LHDQSAKGVS AFQESLVSNR PEMPRQNSDP TSEMPPPAPR
660 670 680 690 700
MASHEEKPDR SSPWLREDAV PPKLSGTTQV PQRTTSISPA LARKNSPGNG
710 720 730 740 750
ESSGGGRSAS QLIRTSNPDL RRTELSLDVA LQRTSSNSSS SSSTPSSQGG
760 770 780 790 800
SQPGSSERNQ PRGSGKSEGS PVALQETSKP IQEEGRELSK PSRPADLTAL
810 820 830 840 850
AKELRELRID EVSRPPLKLT DYSSSSEDSD SSEDEDGTVG HDGTVSVSDI
860 870 880 890 900
PRIMPSVQGN NESFTSSHDD SLTDSYNDES KDGTLRMREN NERQRLGHGE
910 920 930 940 950
SNGFAGHGNL PDLLQQSHSP SGTPTGLNSQ DLDSMDEFGL GGGSKASFTP
960 970 980 990 1000
FVDPRVYQTS PTDDNDESSA AAMFANELLR QEQAKLNEAR KISVVNVNPT
1010 1020 1030 1040 1050
NIRPHSDTPE IRKYKKRFNS EILCAALWGV NLLVGTENGL MLLDRSGQGK
1060 1070 1080 1090 1100
VYNLITRRRF QQMDVLEGLN VLVTISGKKN KLRVYYLSWL RNRILHNDPE
1110 1120 1130 1140 1150
VEKKQGWITV GELEGCIHYK VVKYERIKFL VIALKNSVEI YAWAPKPYHK
1160 1170 1180 1190 1200
FMAFKSFTEL QHRPQLVDLT VEEGQRLKVI YGSSVGFHVI DVDSGSPYDI
1210 1220 1230 1240 1250
YIPSHIQSTV TPHAIVVLPK TDGMEMLLCY EDEGVYVNTY GRITKDVVLQ
1260 1270 1280 1290 1300
WGEMPTSVAY IHSNQIMGWG EKAIEIRSVE TGHLDGVFMH KRAQRLKFLC
1310 1320 1330
ERNDKVFFAS VRSGGSSQVF FMTLNRNSLM NW
Length:1,332
Mass (Da):151,393
Last modified:January 20, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3AF8154C1634EC5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0UY93B0UY93_DANRE
TRAF2 and NCK-interacting kinase a
tnika
1,303Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR392026 Genomic DNA No translation available.
CR848726 Genomic DNA No translation available.
CT027687 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005163447.1, XM_005163390.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000161407.2; ENSDARP00000133707.1; ENSDARG00000056218.8

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
325042

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR392026 Genomic DNA No translation available.
CR848726 Genomic DNA No translation available.
CT027687 Genomic DNA No translation available.
RefSeqiXP_005163447.1, XM_005163390.3

3D structure databases

AlphaFoldDBiA0A0R4IEP9
SMRiA0A0R4IEP9
ModBaseiSearch...

Genome annotation databases

EnsembliENSDART00000161407.2; ENSDARP00000133707.1; ENSDARG00000056218.8
GeneIDi325042

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
325042
ZFINiZDB-GENE-030131-3767, tnika

Phylogenomic databases

GeneTreeiENSGT00950000183196
OrthoDBi533537at2759

Enzyme and pathway databases

ReactomeiR-DRE-2559580, Oxidative Stress Induced Senescence

Gene expression databases

ExpressionAtlasiA0A0R4IEP9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001180, CNH_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00780, CNH, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00036, CNH, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219, CNH, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0R4IEP9_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0R4IEP9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: May 25, 2022
This is version 36 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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