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UniProtKB - A0A0R4IEP9 (A0A0R4IEP9_DANRE)
Protein
Submitted name:
TRAF2 and NCK-interacting kinase a
Gene
tnika
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- convergent extension involved in gastrulation Source: ZFIN
- gastrulation Source: ZFIN
- intracellular signal transduction Source: GO_Central
- MAPK cascade Source: GO_Central
- neuron projection morphogenesis Source: GO_Central
- protein phosphorylation Source: GO_Central
- regulation of cell shape Source: ZFIN
- regulation of MAPK cascade Source: GO_Central
Keywordsi
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DRE-2559580, Oxidative Stress Induced Senescence |
Names & Taxonomyi
Protein namesi | Submitted name: TRAF2 and NCK-interacting kinase a |
Gene namesi | Name:tnikaImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030131-3767, tnika |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 289 | Protein kinaseInterPro annotationAdd BLAST | 265 | |
Domaini | 1019 – 1306 | CNHInterPro annotationAdd BLAST | 288 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 308 – 345 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 407 – 432 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 520 – 933 | DisorderedSequence analysisAdd BLAST | 414 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 321 – 335 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 563 – 577 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 597 – 639 | Polar residuesSequence analysisAdd BLAST | 43 | |
Compositional biasi | 650 – 666 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 675 – 777 | Polar residuesSequence analysisAdd BLAST | 103 | |
Compositional biasi | 799 – 815 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 851 – 871 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 872 – 896 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 912 – 932 | Polar residuesSequence analysisAdd BLAST | 21 |
Phylogenomic databases
GeneTreei | ENSGT00950000183196 |
OrthoDBi | 533537at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001180, CNH_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00780, CNH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00036, CNH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50219, CNH, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0A0R4IEP9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASDSPARSL DEIDLSTLRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL
60 70 80 90 100
AAIKCMDVTG EEEEEIKAEI NMLKKYSHHR NIATYYGAFI KKNPPGVDDQ
110 120 130 140 150
LWLVMEFCGA GSVTDLIKNT KGNSLKEDWT AYISREILRG LTHLHQHKVI
160 170 180 190 200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVSRRNTFIG TPYWMAPEVI
210 220 230 240 250
ACDENPDATY DYKSDLWSLG ITALEMAEGA PPLCELHPMR ALFLIPRNAP
260 270 280 290 300
PRLKSKKWTK RFHSFIESCL VKNHNMRPGT DQLLKHPFIR DMANERTIRI
310 320 330 340 350
QLKDHIDRTR KKRGERDETE YEYSGSEEEE EAMLEIGEPS SIINIPGEST
360 370 380 390 400
LRRDFLRLQV ANKERSDALR RQQLEQQQNE GHKHQLLAER QKRIEEQKEQ
410 420 430 440 450
RRRLEEQQRR EREARKQQEQ RHRYEELRRE EERRQAEREQ EYIRRQLEEE
460 470 480 490 500
QRQLEILQQQ LLQEQALLLE YKRKQVEEQR QADRLQRQLQ QERAYLVSLQ
510 520 530 540 550
QQQQQQQQDS RPEEKKQLYH YKDAVNPSDK PAWAKKVEER SKLNRQSSPA
560 570 580 590 600
LQHKVANRIS DPSLPPRSES FSSGGMQPAR TPPMHRPVEP QMAHLVPVRS
610 620 630 640 650
HSSSMSVSQS LHDQSAKGVS AFQESLVSNR PEMPRQNSDP TSEMPPPAPR
660 670 680 690 700
MASHEEKPDR SSPWLREDAV PPKLSGTTQV PQRTTSISPA LARKNSPGNG
710 720 730 740 750
ESSGGGRSAS QLIRTSNPDL RRTELSLDVA LQRTSSNSSS SSSTPSSQGG
760 770 780 790 800
SQPGSSERNQ PRGSGKSEGS PVALQETSKP IQEEGRELSK PSRPADLTAL
810 820 830 840 850
AKELRELRID EVSRPPLKLT DYSSSSEDSD SSEDEDGTVG HDGTVSVSDI
860 870 880 890 900
PRIMPSVQGN NESFTSSHDD SLTDSYNDES KDGTLRMREN NERQRLGHGE
910 920 930 940 950
SNGFAGHGNL PDLLQQSHSP SGTPTGLNSQ DLDSMDEFGL GGGSKASFTP
960 970 980 990 1000
FVDPRVYQTS PTDDNDESSA AAMFANELLR QEQAKLNEAR KISVVNVNPT
1010 1020 1030 1040 1050
NIRPHSDTPE IRKYKKRFNS EILCAALWGV NLLVGTENGL MLLDRSGQGK
1060 1070 1080 1090 1100
VYNLITRRRF QQMDVLEGLN VLVTISGKKN KLRVYYLSWL RNRILHNDPE
1110 1120 1130 1140 1150
VEKKQGWITV GELEGCIHYK VVKYERIKFL VIALKNSVEI YAWAPKPYHK
1160 1170 1180 1190 1200
FMAFKSFTEL QHRPQLVDLT VEEGQRLKVI YGSSVGFHVI DVDSGSPYDI
1210 1220 1230 1240 1250
YIPSHIQSTV TPHAIVVLPK TDGMEMLLCY EDEGVYVNTY GRITKDVVLQ
1260 1270 1280 1290 1300
WGEMPTSVAY IHSNQIMGWG EKAIEIRSVE TGHLDGVFMH KRAQRLKFLC
1310 1320 1330
ERNDKVFFAS VRSGGSSQVF FMTLNRNSLM NW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB0UY93 | B0UY93_DANRE | TRAF2 and NCK-interacting kinase a | tnika | 1,303 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR392026 Genomic DNA No translation available. CR848726 Genomic DNA No translation available. CT027687 Genomic DNA No translation available. |
RefSeqi | XP_005163447.1, XM_005163390.3 |
Genome annotation databases
Ensembli | ENSDART00000161407.2; ENSDARP00000133707.1; ENSDARG00000056218.8 |
GeneIDi | 325042 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR392026 Genomic DNA No translation available. CR848726 Genomic DNA No translation available. CT027687 Genomic DNA No translation available. |
RefSeqi | XP_005163447.1, XM_005163390.3 |
3D structure databases
AlphaFoldDBi | A0A0R4IEP9 |
SMRi | A0A0R4IEP9 |
ModBasei | Search... |
Genome annotation databases
Ensembli | ENSDART00000161407.2; ENSDARP00000133707.1; ENSDARG00000056218.8 |
GeneIDi | 325042 |
Organism-specific databases
CTDi | 325042 |
ZFINi | ZDB-GENE-030131-3767, tnika |
Phylogenomic databases
GeneTreei | ENSGT00950000183196 |
OrthoDBi | 533537at2759 |
Enzyme and pathway databases
Reactomei | R-DRE-2559580, Oxidative Stress Induced Senescence |
Gene expression databases
ExpressionAtlasi | A0A0R4IEP9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001180, CNH_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00780, CNH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00036, CNH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50219, CNH, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0R4IEP9_DANRE | |
Accessioni | A0A0R4IEP9Primary (citable) accession number: A0A0R4IEP9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 20, 2016 |
Last sequence update: | January 20, 2016 | |
Last modified: | May 25, 2022 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |