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Entry version 22 (13 Feb 2019)
Sequence version 2 (11 May 2016)
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Protein
Submitted name:

Coagulation factor VIII, procoagulant component

Gene

f8

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: ZFIN
  • platelet activation Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-bindingSAAS annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-114608 Platelet degranulation
R-DRE-140837 Intrinsic Pathway of Fibrin Clot Formation
R-DRE-140875 Common Pathway of Fibrin Clot Formation
R-DRE-204005 COPII-mediated vesicle transport
R-DRE-5694530 Cargo concentration in the ER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Coagulation factor VIII, procoagulant componentImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:f8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-090629-2 f8

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500725965028 – 1674Sequence analysisAdd BLAST1647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi172 ↔ 198UniRule annotation
Disulfide bondi263 ↔ 345UniRule annotation
Disulfide bondi542 ↔ 568UniRule annotation
Disulfide bondi644 ↔ 725UniRule annotation
Disulfide bondi1170 ↔ 1196UniRule annotation
Disulfide bondi1237 ↔ 1241UniRule annotation
Disulfide bondi1359 ↔ 1509UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A0R4IBQ7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000011213

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1359 – 1509F5/8 type CInterPro annotationAdd BLAST151
Domaini1514 – 1668F5/8 type CInterPro annotationAdd BLAST155

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157994

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSFPFNT

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00057 FA58C, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 2 hits
2.60.40.420, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011706 Cu-oxidase_2
IPR033138 Cu_oxidase_CS
IPR008972 Cupredoxin
IPR000421 FA58C
IPR024715 Factor_5/8_like
IPR014707 Factor_8
IPR008979 Galactose-bd-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45309 PTHR45309, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07731 Cu-oxidase_2, 1 hit
PF00754 F5_F8_type_C, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000354 Factors_V_VIII, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00231 FA58C, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503 SSF49503, 6 hits
SSF49785 SSF49785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 2 hits
PS00079 MULTICOPPER_OXIDASE1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A0R4IBQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XVCVCVMKTL LFLLLLSACQ EYSCVSAKTL EFFIAAVETK WEYVFTDTAD
60 70 80 90 100
PAANQRKFAS GVQKYTKAVY TEYTDSTFTT PKSKPPWAGI QGPTIRTVVN
110 120 130 140 150
DRVVVHFKNF ASQSFSISPI GIPYWKQSEG AGYEDSSSFQ ERADDSVPPG
160 170 180 190 200
GYYRYVWDIS PNSGPTTSDP DCLTYIYSSQ VDIIRDFNSG LIGALLICKT
210 220 230 240 250
DALTEDRQRR VPEFILLLSV FDESKSWYQE VGRAEKLKKT SSTNQYHTIN
260 270 280 290 300
GYINSTLPGL SVCEKSPQVS WHLIGLGSSP EIHSIQFEGH TLKVFDHKRV
310 320 330 340 350
TVEMTPMTFT TALMKPSATG RFLISCRIHS HQTAGMNAFF TVENCPEPAP
360 370 380 390 400
LPLPDKRNVK HTNDDEEEDD EDNMFSVVFK QGGPISVLRS SAKGRPKVWL
410 420 430 440 450
HYISAEETDW DYTAQSGDRP ASSAGSEWFR KGPQRLGGVY KKVAFVEYTD
460 470 480 490 500
KTFSVKKTTG RTLIGPELRG EVGDKFQIVF KNMASRPFNI YPNGLTSVQP
510 520 530 540 550
LKTTNKDKQV DLRSLAVPPG EIMTYLWKLT AEDGPTDADP RCLTRIYQST
560 570 580 590 600
LDPARDVASG LVGPLIICKS QSLDKRGRVV TSDKEKKLLF TVFDENRSWY
610 620 630 640 650
FEENIKRNSE DPAKINRNDL DFYNSNIMHT VNGFMFNHLQ YKMCVGDVIL
660 670 680 690 700
WHVASIGMQN NFLSVYFTGN TFEREKAYGT VLTLFPMTGD TVTTEVEMMG
710 720 730 740 750
EWEVSAFDPS LKERGMSVRY TVVNCERVLP KVDYDDYDEE FMEIIEKNFP
760 770 780 790 800
NPRGTMGKNR TIAIRVCRNR TVTDSGSNTR HNETLNRSRV CEIRYVPVKE
810 820 830 840 850
ENDLEALSQG GIPQDILDQL DDEIGGNSVE RQKRSHQESH TVTSSYTELP
860 870 880 890 900
QNQHNETQAG ADTTNELLRK FLFKHTNLNI SRRTQDEMEE SLNPLSFNTI
910 920 930 940 950
RNISMVEIEK ARSRRELWSV GKTNQKDVKA MSDNEVLEDS GRKRDKMEES
960 970 980 990 1000
LNPLSYNYKD LKKYSEMGLE PASNSSDDKM YGKKSVTSDY DDYSDEGSVV
1010 1020 1030 1040 1050
GLDHFVEDNV GVRSTESKFR SYYIAAEEVM WDYGIDKPAQ LIKPREMRRG
1060 1070 1080 1090 1100
LRKYFPTYKK VVFRAYQDRD FRHPIKRGEL DEHLGIMGPV VKAEINDVLT
1110 1120 1130 1140 1150
VVFKNLASRP YSFHLHGVYD KTPGSFSTGM GPENPKLEEE AGDPVPPGEE
1160 1170 1180 1190 1200
RVYNWRISRR QGPSASEFDC KAGAYYSNVN MEKDINSGLI GPMLICRPGT
1210 1220 1230 1240 1250
LNPRVLLQPD VTDFFLLFTT FDERKSWYLD YNIRKFCIPP CQARVDDPWF
1260 1270 1280 1290 1300
QTSNKFAAIN GYVSETLPGL RVEQYRTARW HLLNLGTQGE FHAVHFHGLP
1310 1320 1330 1340 1350
FRVGKDQEHR MGIFNLYPGV FGTVEMRPAI AGTWLIECTI GEHQLAGMRA
1360 1370 1380 1390 1400
KLLVYNPQCN QPIGMQSRWI TNKQITASDY YGDWKPELAR LELTGSINAW
1410 1420 1430 1440 1450
MGSSPNSWLQ VDLLRPMILH GIQTQGAKTS MGLSEFFTIL YSISYSNDQE
1460 1470 1480 1490 1500
NWSVYRGNST KPYYTFNGNM DGSRIKENLF SPPIVGRYIR IHPLTFQKQP
1510 1520 1530 1540 1550
TLRIELLGCD LNSCSLPLGM ERRSIPNSSI SASSFLNKWL LSWSPDLARI
1560 1570 1580 1590 1600
HQEGRANAWR PKSNNPHEWL QVDFASVKRV TGLITQGARS VLKPMMVTEF
1610 1620 1630 1640 1650
TVSVSNDGHS WSSVTEQGTD SEQIFEGNSD NNEETLNIFD PPLFTRFIRV
1660 1670
HPKGWVNDIA LRLEFLGCDT QPTL
Length:1,674
Mass (Da):190,253
Last modified:May 11, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C0B3D5DF09A37E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4INL6A0A0R4INL6_DANRE
Coagulation factor VIII, procoagula...
f8
1,386Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FP103059 Genomic DNA No translation available.
FQ377596 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000172676; ENSDARP00000130264; ENSDARG00000101385

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP103059 Genomic DNA No translation available.
FQ377596 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011213

Proteomic databases

PaxDbiA0A0R4IBQ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000172676; ENSDARP00000130264; ENSDARG00000101385

Organism-specific databases

ZFINiZDB-GENE-090629-2 f8

Phylogenomic databases

GeneTreeiENSGT00940000157994
OMAiRSFPFNT

Enzyme and pathway databases

ReactomeiR-DRE-114608 Platelet degranulation
R-DRE-140837 Intrinsic Pathway of Fibrin Clot Formation
R-DRE-140875 Common Pathway of Fibrin Clot Formation
R-DRE-204005 COPII-mediated vesicle transport
R-DRE-5694530 Cargo concentration in the ER

Family and domain databases

CDDicd00057 FA58C, 2 hits
Gene3Di2.60.120.260, 2 hits
2.60.40.420, 6 hits
InterProiView protein in InterPro
IPR011706 Cu-oxidase_2
IPR033138 Cu_oxidase_CS
IPR008972 Cupredoxin
IPR000421 FA58C
IPR024715 Factor_5/8_like
IPR014707 Factor_8
IPR008979 Galactose-bd-like_sf
PANTHERiPTHR45309 PTHR45309, 2 hits
PfamiView protein in Pfam
PF07731 Cu-oxidase_2, 1 hit
PF00754 F5_F8_type_C, 2 hits
PIRSFiPIRSF000354 Factors_V_VIII, 2 hits
SMARTiView protein in SMART
SM00231 FA58C, 2 hits
SUPFAMiSSF49503 SSF49503, 6 hits
SSF49785 SSF49785, 2 hits
PROSITEiView protein in PROSITE
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 2 hits
PS00079 MULTICOPPER_OXIDASE1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0R4IBQ7_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0R4IBQ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: May 11, 2016
Last modified: February 13, 2019
This is version 22 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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