UniProtKB - A0A0R3U5L3 (A0A0R3U5L3_9CEST)
Protein
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
Gene
MCOS_LOCUS2018
Organism
Mesocestoides corti
Status
Functioni
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.UniRule annotation
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+UniRule annotationARBA annotationEC:3.1.4.11UniRule annotationARBA annotation
GO - Molecular functioni
- calcium ion binding Source: UniProtKB-UniRule
- phosphatidylinositol phospholipase C activity Source: UniProtKB-UniRule
GO - Biological processi
- intracellular signal transduction Source: InterPro
- lipid catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | HydrolaseUniRule annotationARBA annotation, TransducerUniRule annotationARBA annotation |
Biological process | Lipid degradationUniRule annotation, Lipid metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesteraseUniRule annotation (EC:3.1.4.11UniRule annotation) |
Gene namesi | ORF Names:MCOS_LOCUS2018Imported |
Organismi | Mesocestoides cortiImported |
Taxonomic identifieri | 53468 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Cestoda › Eucestoda › Cyclophyllidea › Mesocestoididae › Mesocestoides |
Proteomesi |
|
Family & Domainsi
Family and domain databases
CDDi | cd13361, PH_PLC_beta, 1 hit |
Gene3Di | 1.20.1230.10, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR042531, PLC-beta_C_sf IPR009535, PLC-beta_CS IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF06631, DUF1154, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PIRSFi | PIRSF000956, PLC-beta, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A0R3U5L3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSDIAKRQR TVPSSKAYDF VWRRPVPAAL REGTYFDRFD EETGTLELGC
60 70 80 90 100
FLRVDEDGFF LFWKSDVNEG QVLELSQVSD VRHGMKPKDE KLVATLTERV
110 120 130 140 150
SSIGKNLDEH IVTVCSGLDL VNISYTNFVA TSPEVASLWI QSVRGLTHNT
160 170 180 190 200
KAQNVCPMTQ LRKHWLRLTL TVNPRGKIPV RVVTKTFASG RNERIIFQSL
210 220 230 240 250
KELGLPSGKN DEVEPSEFTF ERFYELYHKI CPRTDIEELF KTLSNGKETL
260 270 280 290 300
TIEKMIEFLN EVQRDPRLNE ILYPYANRQT IRYIQETYES RDENTSSDTL
310 320 330 340 350
SLKGFYRYLM SDDNAPVFLD RLDICQDMDQ PLCHYYINSS HNTYLIGRQF
360 370 380 390 400
GGKSSVEIYR QVLLAGCRCI ELDCWDGKGE DQEPIITHGK AMCSDILFKD
410 420 430 440 450
VIYAVRDTAF VTSDYPLIMS FENHCSKHQQ YKLAKYCEDI LGDMLLTKPL
460 470 480 490 500
DKYPLEAGVP LPSPEKLKRK ILIKNKRLEP DVEKHQLELF MKGQADPVQE
510 520 530 540 550
DDDVAEDPDP VVTPDCDVGP MNGDIDPHPE TKLRPGSGQI NVLSTSLPLS
560 570 580 590 600
SSLIGKLSET EMKRLITKKG SLTAEEEQAM LAQYHYTGAT KTIHPLLSSM
610 620 630 640 650
VNYAQPVKFQ GFDVAEDENV HYHMSSFSET VALGLMKNEA IEFVNYNKRQ
660 670 680 690 700
MSRIYPRGNR VESSNYMPQI FWNAGCQMVA LNFQTPDLAM QLNQGKFEYN
710 720 730 740 750
GNCGYLLKPE FMRRPERQFD PFSESPMDGV IAATCEVRII SGQFLSDRKV
760 770 780 790 800
GTYVEVDMYG LPTDTIRKEF RTRVVPNNGL NPVYGEDAVF VFRKVVLPDL
810 820 830 840 850
AVLRFAVYED TGKLIGQRVL PLDGLQSGYR HISLRTEGNF PLSLPTLFCR
860 870 880 890 900
VSLTTYVPEG LNDLVDALSD PRAFLSKEEQ RMKQVGILLE PVALLLLHMF
910 920 930 940 950
TIPISVTSHL KLASMGIDSS EIDDVPTSST KLAAMLKQRP MGMGNLSNAP
960 970 980 990 1000
SANSAAGLLP SGVGSVAAAS SAGLTLPGVG ASADHQKSTG STVVSPSANP
1010 1020 1030 1040 1050
LTSGGVGVSG ATSGPSANSA KKEDKKAEDP KFPPISLSML RSDKNYRKLV
1060 1070 1080 1090 1100
KKQAKELEAL QRRHEKEAAA MLRAHTLLTD KLNSSHAKAI ASSTSSLRST
1110 1120 1130 1140 1150
PQKMNGINTP MKEAHIAQMN DLVRQQTDEW SKLKYTQMNE IHGLVLTFMD
1160 1170 1180 1190 1200
ARKDLLLKIL RDAHDEQKRL LKQIQERENK DMKAQQIKIS LDSNRNVMND
1210 1220 1230 1240 1250
PRLKNKAERD RRIRELKDYN TKRFIDQRKA QAQRNDRQVQ DLLRRHEEEE
1260 1270 1280
HGVIAGVNLE RDDLIRSYRE ELLATKRTTM I
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | UXSR01000300 Genomic DNA Translation: VDD76015.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | UXSR01000300 Genomic DNA Translation: VDD76015.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
CDDi | cd13361, PH_PLC_beta, 1 hit |
Gene3Di | 1.20.1230.10, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR042531, PLC-beta_C_sf IPR009535, PLC-beta_CS IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF06631, DUF1154, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PIRSFi | PIRSF000956, PLC-beta, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0R3U5L3_9CEST | |
Accessioni | A0A0R3U5L3Primary (citable) accession number: A0A0R3U5L3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 20, 2016 |
Last sequence update: | June 8, 2016 | |
Last modified: | August 12, 2020 | |
This is version 28 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |