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Protein

Pyruvate carboxylase

Gene

AOT91_26715

Organism
Mycobacteroides sp. H092
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate.UniRule annotation

Cofactori

biotinUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117ATPUniRule annotation1
Binding sitei200ATPUniRule annotation1
Binding sitei235ATPUniRule annotation1
Active sitei292UniRule annotation1
Metal bindingi534Divalent metal cationUniRule annotation1
Binding sitei606SubstrateUniRule annotation1
Metal bindingi704Divalent metal cation; via carbamate groupUniRule annotation1
Metal bindingi733Divalent metal cationUniRule annotation1
Metal bindingi735Divalent metal cationUniRule annotation1
Binding sitei868SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
LigandATP-bindingUniRule annotation, BiotinUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate carboxylaseUniRule annotation (EC:6.4.1.1UniRule annotation)
Gene namesi
ORF Names:AOT91_26715Imported
OrganismiMycobacteroides sp. H092Imported
Taxonomic identifieri1720573 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceae
Proteomesi
  • UP000051385 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 450Biotin carboxylationInterPro annotationAdd BLAST450
Domaini121 – 317ATP-graspInterPro annotationAdd BLAST197
Domaini525 – 794Pyruvate carboxyltransferaseInterPro annotationAdd BLAST270
Domaini1054 – 1128Lipoyl-bindingInterPro annotationAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili174 – 194Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR003379 Carboxylase_cons_dom
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR000891 PYR_CT
IPR005930 Pyruv_COase
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
PF00682 HMGL-like, 1 hit
PF02436 PYC_OADA, 1 hit
PIRSFiPIRSF001594 Pyruv_carbox, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01235 pyruv_carbox, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00867 CPSASE_2, 1 hit
PS50991 PYR_CT, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0R3EFE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSKVLVANR GEIAIRAFRA AYELGAETVA VYPYEDRNSG HRLKADEAYQ
60 70 80 90 100
IGEKGHPVRA YLSVSEVVKA AKNAGADAIY PGYGFLSENP DLAAACAKAG
110 120 130 140 150
ITFVGPPADV LELTGNKARA IAAAREAGLP VLSSSEPSAS VDELLTASES
160 170 180 190 200
MEFPVFVKAV AGGGGRGMRR VAEREQLREA IEAASREAES AFGDPTVFLE
210 220 230 240 250
QAVINPRHIE VQILADTAGN VIHLYERDCS VQRRHQKVIE LAPAPNLPAE
260 270 280 290 300
LREKICSDAV AFARHIGYSC AGTVEFLLDE RGRHVFIEMN PRIQVEHTVT
310 320 330 340 350
EEITDVDLVA SQLRIASGET LDDLGLHQET LPAPRGFALQ CRITTEDPAN
360 370 380 390 400
GFRPDTGRIT AYRSPGGAGI RLDGGTTLGA EVGAHFDSML VKLTCRGRDF
410 420 430 440 450
QTAVARARRA VAEFRIRGVA TNIPFLQAVL DDPDFRAGHV TTSFIEERPQ
460 470 480 490 500
LLTARSSADR GTKILNYLAD ITVNKPHGAK PSKVYPHDKL PAIDLSVPPP
510 520 530 540 550
DGSRQRLLAL GPEGFAKALR EQKAVGLTDT TFRDAHQSLL ATRVRTTGLL
560 570 580 590 600
AVAPYVARLT PELLSIEAWG GATYDVALRF LKEDPWERLA ELREAVPNIC
610 620 630 640 650
LQMLLRGRNT VGYTPYPETV TKAFIREATA TGVDIYRIFD ALNNIEAMRP
660 670 680 690 700
AIDAVREVGG SIAEVAMCYT GDLSNPGENL YTLDYYLKLA EQIVDAGAHV
710 720 730 740 750
LAIKDMAGLL RPPAAATLVT ALRSRFDLPV HVHTHDTAGG QLATYLAAWQ
760 770 780 790 800
AGADAVDGAA APMAGTTSQP SLSAIVAAAA HSEYDTGVSL TAVCDLEPYW
810 820 830 840 850
EALRKVYAPF ESGLPSPTGR VYTHEIPGGQ LSNLRQQAIA LGLGDQFEEI
860 870 880 890 900
EARYAAADRM LGRLVKVTPS SKVVGDLALA LVGTGVSADE FASDPGRFDI
910 920 930 940 950
PESVIGFLRG ELGDPPGGWP EPFRTRALEG RGAARAEVEL TADDEAALDG
960 970 980 990 1000
DSATRRAALN RLLFPGPTKE FLAHREQYGD TSRLSANQFF YGLRYGEEHR
1010 1020 1030 1040 1050
VKLEKGVELL IGIEAISDAD ERGMRTVMCI LNGQLRPVQV RDRSIDSAVA
1060 1070 1080 1090 1100
SAEKADRSNA DHVPAPFAGV VTLSVVSGQE VAAGETIGTI EAMKMEASIT
1110 1120
APKAGTVARV ALTETSQVEG GDLLVVIS
Length:1,128
Mass (Da):121,038
Last modified:January 20, 2016 - v1
Checksum:i2CA327A0DD1D1E7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LJYP01000083 Genomic DNA Translation: KRQ20695.1
RefSeqiWP_057967655.1, NZ_LJYP01000083.1

Genome annotation databases

EnsemblBacteriaiKRQ20695; KRQ20695; AOT91_26715

Similar proteinsi

Entry informationi

Entry nameiA0A0R3EFE8_9MYCO
AccessioniPrimary (citable) accession number: A0A0R3EFE8
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: July 18, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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