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Protein

Ribose-phosphate pyrophosphokinase

Gene

prs

Organism
Acinetobacter baumannii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).UniRule annotation

Catalytic activityi

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 Mg2+ ions per subunit.UniRule annotation

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-phosphate pyrophosphokinase (prs), Ribose-phosphate pyrophosphokinase (prs), Ribose-phosphate pyrophosphokinase (prs)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi131MagnesiumUniRule annotation1
Metal bindingi170MagnesiumUniRule annotation1
Active sitei194UniRule annotation1
Binding sitei196Ribose-5-phosphateUniRule annotation1
Binding sitei220Ribose-5-phosphateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 39ATPUniRule annotation3
Nucleotide bindingi96 – 97ATPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processNucleotide biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00087; UER00172

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-phosphate pyrophosphokinaseUniRule annotation (EC:2.7.6.1UniRule annotation)
Short name:
RPPKUniRule annotation
Alternative name(s):
5-phospho-D-ribosyl alpha-1-diphosphateUniRule annotation
Phosphoribosyl diphosphate synthaseUniRule annotation
Phosphoribosyl pyrophosphate synthaseUniRule annotation
Short name:
P-Rib-PP synthaseUniRule annotation
Short name:
PRPP synthaseUniRule annotation
Short name:
PRPPaseUniRule annotation
Gene namesi
Name:prsUniRule annotationImported
ORF Names:A7M79_02550Imported, A7M90_13850Imported, A7N09_01070Imported, AB895_2312Imported, AbaHEU2_06445Imported, ABUW_3097Imported, AM462_10500Imported, APD06_08855Imported, AZE33_04190Imported, B4R90_07695Imported, B9X91_00805Imported, B9X95_05765Imported, BGC29_09210Imported, BWP00_12125Imported, C2U32_18420Imported, C3415_14605Imported, C7G90_15790Imported, CAS83_12630Imported, CBE85_08855Imported, CBI29_00852Imported, CEJ63_15220Imported, CHQ89_11385Imported, CPI82_11070Imported, IX87_18475Imported, LV38_02915Imported
OrganismiAcinetobacter baumanniiImported
Taxonomic identifieri470 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
Proteomesi
  • UP000179791 Componenti: Unassembled WGS sequence
  • UP000194699 Componenti: Unassembled WGS sequence
  • UP000195460 Componenti: Unassembled WGS sequence
  • UP000236385 Componenti: Chromosome
  • UP000237220 Componenti: Unassembled WGS sequence
  • UP000194957 Componenti: Unassembled WGS sequence
  • UP000051322 Componenti: Unassembled WGS sequence
  • UP000188718 Componenti: Unassembled WGS sequence
  • UP000238251 Componenti: Unassembled WGS sequence
  • UP000032746 Componenti: Chromosome
  • UP000197394 Componenti: Unassembled WGS sequence
  • UP000216072 Componenti: Unassembled WGS sequence
  • UP000194553 Componenti: Unassembled WGS sequence
  • UP000179937 Componenti: Unassembled WGS sequence
  • UP000094982 Componenti: Unassembled WGS sequence
  • UP000036720 Componenti: Unassembled WGS sequence
  • UP000028932 Componenti: Chromosome
  • UP000223291 Componenti: Unassembled WGS sequence
  • UP000179770 Componenti: Unassembled WGS sequence
  • UP000070590 Componenti: Chromosome
  • UP000237687 Componenti: Chromosome
  • UP000216874 Componenti: Unassembled WGS sequence
  • UP000076314 Componenti: Unassembled WGS sequence
  • UP000238506 Componenti: Unassembled WGS sequence
  • UP000197701 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 121Pribosyltran_NInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni224 – 228Ribose-5-phosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C5T Bacteria
COG0462 LUCA
KOiK00948

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_00583_B RibP_PPkinase_B, 1 hit
InterProiView protein in InterPro
IPR000842 PRib_PP_synth_CS
IPR029099 Pribosyltran_N
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR005946 Rib-P_diPkinase
IPR037515 Rib-P_diPkinase_bac
PANTHERiPTHR10210 PTHR10210, 1 hit
PfamiView protein in Pfam
PF14572 Pribosyl_synth, 1 hit
PF13793 Pribosyltran_N, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01251 ribP_PPkin, 1 hit
PROSITEiView protein in PROSITE
PS00114 PRPP_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0Q1HQY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNLVVFSGN AHPQFAQKVV SHLHIPLGAA SVGQFSDGEI SVEITENVRG
60 70 80 90 100
KDVFIVQPTC APTNDNLMEI LVMADALRRA SAGRITAVIP YFGYARQDRR
110 120 130 140 150
PRSARVPITA KVVADMLTTV GIDRVVMIDL HADQIQGFFD IPVDNIYGTP
160 170 180 190 200
ALLADLRQQQ HDNLMVVSPD VGGVVRARAV AKQMGDIDLA IIDKRRQKAN
210 220 230 240 250
ESQVMHLIGD VKDRDCVIVD DMVDTAGTLC KAADALKQFG ARRVVAYATH
260 270 280 290 300
PVLSGKAIEN LRNSVIDELV VTDTIPLSEE ALNLGKIRQV SVASMVAETI
310
RRINNEESIS AMFDSL
Length:316
Mass (Da):34,417
Last modified:January 20, 2016 - v1
Checksum:i1949BA517F54C54D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009257 Genomic DNA Translation: AIL80520.1
CP008706 Genomic DNA Translation: AKA32804.1
CP014528 Genomic DNA Translation: AMN00412.1
CP021782 Genomic DNA Translation: ASF76243.1
CP026125 Genomic DNA Translation: AUT39789.1
CP027528 Genomic DNA Translation: AVN25991.1
CVLF01000090 Genomic DNA Translation: CQR89334.1
LFYZ01000001 Genomic DNA Translation: KMV05135.1
LLFE01000034 Genomic DNA Translation: KQD20842.1
LRDW01000027 Genomic DNA Translation: KZA23392.1
MDWM01000161 Genomic DNA Translation: ODP67377.1
LYIX01002134 Genomic DNA Translation: OIF71024.1
LYKI01000004 Genomic DNA Translation: OIG74821.1
LYKQ01000045 Genomic DNA Translation: OIH05693.1
MTGG01000024 Genomic DNA Translation: OOD20517.1
NGCH01000046 Genomic DNA Translation: OTL55954.1
NGEL01000056 Genomic DNA Translation: OTM90925.1
NGHO01000057 Genomic DNA Translation: OTT21025.1
NCYH01000010 Genomic DNA Translation: OVL10945.1
NGKM01000007 Genomic DNA Translation: OWK66849.1
NOXP01000008 Genomic DNA Translation: OZT29519.1
NKKG01000047 Genomic DNA Translation: PAM69189.1
NXDV01000007 Genomic DNA Translation: PHQ02757.1
PQVM01000032 Genomic DNA Translation: POZ06611.1
NQXU01000005 Genomic DNA Translation: PPC53867.1
PXNA01000023 Genomic DNA Translation: PSE16949.1
RefSeqiWP_001133287.1, NZ_QCYE01000004.1

Genome annotation databases

EnsemblBacteriaiAIL80520; AIL80520; IX87_18475
AKA32804; AKA32804; ABUW_3097
AKQ27857; AKQ27857; ACX60_14225
AMN00412; AMN00412; AZE33_04190
BAP67774; BAP67774; IOMTU433_3007
KMV05135; KMV05135; AB895_2312
KMV12739; KMV12739; AB988_2145
KQD20842; KQD20842; APD06_08855
KQD93373; KQD93373; APD31_07860
KUI75048; KUI75048; AQ480_19120
KZA23392; KZA23392; LV38_02915
OBE55931; OBE55931; A7934_17370
ODP67377; ODP67377; BGC29_09210
GeneIDi31350574
KEGGiabaa:IX88_06135
abau:IX87_18475
abk:LX00_03870
abw:BL01_07845
PATRICifig|470.1288.peg.1557

Similar proteinsi

Entry informationi

Entry nameiA0A0Q1HQY9_ACIBA
AccessioniPrimary (citable) accession number: A0A0Q1HQY9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: July 18, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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