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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Geobacillus sp. PA-3
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationSAAS annotation (EC:1.4.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotationImported
ORF Names:GEPA3_2417Imported
OrganismiGeobacillus sp. PA-3Imported
Taxonomic identifieri1699078 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000050486 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0Q0UT82
SMRiA0A0Q0UT82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0Q0UT82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHRYLPMTE EDKQEMLKTI GVASIDELFA DIPEQVRFRG ELNVKRAKSE
60 70 80 90 100
PELWKELSAL ADKNANARQY VSFLGAGVYD HYIPAVVDHV LMRSEFYTAY
110 120 130 140 150
TPYQPEISQG ELQAIFEFQT MVCELTGMDV ANSSMYDGGT ALAEAVLLSA
160 170 180 190 200
AHTKRRKVLI SNAVHPQYRE VVRTYANGQR LEVKEIPYNG GVTDLEVLAA
210 220 230 240 250
EMGDDVACVV IQYPNFFGQI EPLKAIEPLV HEKKSLFVVA SNPLALGVLT
260 270 280 290 300
PPGEFGADIV VGDMQPFGIP MQFGGPHCGY FAVKAPLMRK IPGRLVGQTT
310 320 330 340 350
DEEGRRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VALSALGKRG
360 370 380 390 400
VKEMATMNMQ KAHYAKSELQ KRGLLSPFAG PFFNEFVIRL NQPVDDVNAR
410 420 430 440
LRQKGIIGGY NLGFDYPELA NHMLVAVTEL RTKEEIDRFV NELGDGHA
Length:448
Mass (Da):49,693
Last modified:January 20, 2016 - v1
Checksum:i918C47A42E927F7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LIDX01000119 Genomic DNA Translation: KQB92590.1
RefSeqiWP_008879841.1, NZ_LIDX01000119.1

Genome annotation databases

EnsemblBacteriaiKQB92590; KQB92590; GEPA3_2417
GeneIDi31761610
PATRICifig|1699078.3.peg.443

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LIDX01000119 Genomic DNA Translation: KQB92590.1
RefSeqiWP_008879841.1, NZ_LIDX01000119.1

3D structure databases

ProteinModelPortaliA0A0Q0UT82
SMRiA0A0Q0UT82
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKQB92590; KQB92590; GEPA3_2417
GeneIDi31761610
PATRICifig|1699078.3.peg.443

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0Q0UT82_9BACI
AccessioniPrimary (citable) accession number: A0A0Q0UT82
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: November 7, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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