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Protein

Mediator of RNA polymerase II transcription subunit 6

Gene

MED6

Organism
Heterocephalus glaber (Naked mole rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 6UniRule annotation
Alternative name(s):
Mediator complex subunit 6UniRule annotation
Gene namesi
Name:MED6Imported
OrganismiHeterocephalus glaber (Naked mole rat)Imported
Taxonomic identifieri10181 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaBathyergidaeHeterocephalus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Subunit structurei

Component of the Mediator complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 6 family.UniRule annotation

Phylogenomic databases

KOiK15128

Family and domain databases

Gene3Di3.10.450.580, 1 hit
InterProiView protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln
PANTHERiPTHR13104 PTHR13104, 1 hit
PfamiView protein in Pfam
PF04934 Med6, 1 hit
PIRSFiPIRSF023869 Mediator_MED6_meta/pln, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0P6J7E7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVDIRDNL LGISWVDSSW IPILNSGSVL DYFSERSNPF YDRTCNNEVV
60 70 80 90 100
KMQRLTLEHL NQMVGVEYIL LHAQEPILFI IRKQQRQSPA QVIPLADYYI
110 120 130 140 150
IAGVIYQAPD LGSVINSRVL TAVHGIQSAF DEAMSYCRYH PSKGYWWHFK
160 170 180 190 200
DHEEQDKVKP KAKRKEEPSS IFQRQRVDAL LVDLRQKFPP KFVQQKSGEK
210 220 230 240
PVPVDQTKKE AEPTPETIKS EEKETTKNVQ QTLSTKGPPE KRIRLQ
Length:246
Mass (Da):28,391
Last modified:January 20, 2016 - v1
Checksum:i9A99010ACE47B51C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GEBF01007445 Transcribed RNA Translation: JAN96187.1
RefSeqiXP_004837351.1, XM_004837294.2

Genome annotation databases

GeneIDi101697915
KEGGihgl:101697915

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GEBF01007445 Transcribed RNA Translation: JAN96187.1
RefSeqiXP_004837351.1, XM_004837294.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101697915
KEGGihgl:101697915

Organism-specific databases

CTDi10001

Phylogenomic databases

KOiK15128

Family and domain databases

Gene3Di3.10.450.580, 1 hit
InterProiView protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln
PANTHERiPTHR13104 PTHR13104, 1 hit
PfamiView protein in Pfam
PF04934 Med6, 1 hit
PIRSFiPIRSF023869 Mediator_MED6_meta/pln, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0P6J7E7_HETGA
AccessioniPrimary (citable) accession number: A0A0P6J7E7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: November 7, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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