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Entry version 16 (11 Dec 2019)
Sequence version 1 (20 Jan 2016)
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Protein
Submitted name:

Inositol 1,4,5-trisphosphate receptor type 3

Gene

ITPR3

Organism
Heterocephalus glaber (Naked mole rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Inositol 1,4,5-trisphosphate receptor type 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITPR3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHeterocephalus glaber (Naked mole rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10181 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaBathyergidaeHeterocephalus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2188 – 2213HelicalSequence analysisAdd BLAST26
Transmembranei2225 – 2243HelicalSequence analysisAdd BLAST19
Transmembranei2255 – 2275HelicalSequence analysisAdd BLAST21
Transmembranei2311 – 2336HelicalSequence analysisAdd BLAST26
Transmembranei2356 – 2378HelicalSequence analysisAdd BLAST23
Transmembranei2485 – 2508HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 173MIRInterPro annotationAdd BLAST61
Domaini174 – 224MIRInterPro annotationAdd BLAST51
Domaini232 – 288MIRInterPro annotationAdd BLAST57
Domaini295 – 369MIRInterPro annotationAdd BLAST75
Domaini375 – 431MIRInterPro annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni320 – 339DisorderedSequence analysisAdd BLAST20
Regioni1127 – 1155DisorderedSequence analysisAdd BLAST29
Regioni1800 – 1847DisorderedSequence analysisAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili90 – 110Sequence analysisAdd BLAST21
Coiled coili2623 – 2643Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1127 – 1150PolyampholyteSequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR035910 RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00779 INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0P6J5U4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK
60 70 80 90 100
KFRDCLFKVC PMNRYSAQKQ YWKAKQSKQD KEKIADVVLL QKLQHAAQME
110 120 130 140 150
RKQNDTENKK AHGDVVKYGG VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV
160 170 180 190 200
TLDATGNEGS WLFIQPFWKL RSNGDNVVVG DKVILNPVNA GQPLHASNYE
210 220 230 240 250
LSDNAGCKEV NSVNCNTSWK INLFMQFCDH LEEVLKGGDV VRLFHAEQEK
260 270 280 290 300
FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
310 320 330 340 350
NGLYRFKHLA TGNYLAAEEN PSYKGDAPDP KAAGAGRAGR RNAGEKIKYR
360 370 380 390 400
LVAVPHGSDI ASLFELDPTT LQKTDSLVPR NSYVRLRHLC TNTWIQSTNV
410 420 430 440 450
PIDADEERPI RLMLGTCPTK EDKEAFAIVS VPVSEIRDLD FANDASSMLA
460 470 480 490 500
SAVEKLNEGF ISQNDRRFVI QLLEDLVFFV SDVPNNGQNV LDIMVAKPNR
510 520 530 540 550
ERQKLMREQN ILKQIFGILK APFRDKGGEG PLVRLEELSD QKNAPYQHMF
560 570 580 590 600
RLCYRVLRHS QDDYRKNQEH IAKQFGMMQS QIGYDILAED TITALLHNNR
610 620 630 640 650
KLLEKHITKT EVETFVSLVR KNREPRFLDY LSDLCVSNHI AIPVTQELIC
660 670 680 690 700
KCVLDPKNSD ILIQTELRPV KEMAQSHEYL SIEYSEEEVW LTWTDKNNEH
710 720 730 740 750
HEKSVRQLAQ EARAGNAHDE NVLSYYRYQL KLFARMCLDR QYLAIDEISQ
760 770 780 790 800
QLGVDLIFLC MADEMLPFDL RASFCHLMLH VHVDRDPQEL VTPVKFARLW
810 820 830 840 850
TEVPTAITIK DYDSNLNASR DDKKNKFAST MEFVEDYLNN VVSEAVPFAN
860 870 880 890 900
EEKNMLTYEV VSLAHNLIYF GFYSFSELLR LTRTLLAIID CVQGPSAMLQ
910 920 930 940 950
GYEDPGGKNV RRSIQGVGHM MTTMVLSRKP SVAGPGVPEP LDRSKFEDKE
960 970 980 990 1000
HIVVMETKLK VLDILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD
1010 1020 1030 1040 1050
GTAPAFDSAT ANLNLDRIGE QAEAMFGVGK TSSMLEVDDE GGRMFLRVLV
1060 1070 1080 1090 1100
HLAMHNYAPL VSGALQLLFK HFSQRQEAMH TFKQVQLLIS AQDVENYKVI
1110 1120 1130 1140 1150
KLELDRLRTM VEKSELWVEK KGSSKGEVGE AAEAGAAKDR KERPTAEEAP
1160 1170 1180 1190 1200
GEKGSENYQI VRGILERLNK MCGVGEQMRK KQQRLLKNMD AHKVMLDLLQ
1210 1220 1230 1240 1250
VPYDKGDAKM LEILRLTHQF LQKFCAGNPG NQALLHKHLH LFLTPGLLEA
1260 1270 1280 1290 1300
ETMQHIFLNN YQLCSEVGEP VLQHFVHLLA THGRHVQYLD FLHTVIKAEG
1310 1320 1330 1340 1350
KYVKKCQDMI MTELTNAGDD VVVFYNDKAS LAHLLDMMKT ARDGVEDHSP
1360 1370 1380 1390 1400
LMYHISLVDL LAACAEGKNV YTEIKCTSLL PLEDVVSVVT HEDCITEVKM
1410 1420 1430 1440 1450
AYVNFVNHCY VDTEVEMKEI YTSNHIWTLF ESFTLDMARV CNRREKRLAD
1460 1470 1480 1490 1500
PALEKYVLTV VLDTISAFFS SPFSENSTSL QTHQTIVVQL LQSTTRLLEC
1510 1520 1530 1540 1550
PWLQQQHKGS VEACIRTLAM VAKGRAISLP MDLDAHISAL LSSGASSAAA
1560 1570 1580 1590 1600
AQRNAASYKT ATRTFPRLTP ATNQWDYKNI IEKLQDIITA LEERLKPLVQ
1610 1620 1630 1640 1650
AELSVLVDVL HWPELLFPEG SEAYQRCESG GFLSKLIQHS KGLMESEQKL
1660 1670 1680 1690 1700
CTKVLRTLQQ MLLKRNKYGD RGNQLRKMLL QNYLQNRKSS SRGELPDPMG
1710 1720 1730 1740 1750
TGLDQDCSAI GATQCRLDKE GATKLVCDLI TSTKNEKIFQ ESIGLAIRLL
1760 1770 1780 1790 1800
DGGNTEIQKS FYNLMTSDKK SERFFKVLHD RMKRAQQETK STVAMNMTDL
1810 1820 1830 1840 1850
GSRPREDHEL ADPTAKGRVT SFSMPGSPYS LGPSLRRGHE ASERTQSNEM
1860 1870 1880 1890 1900
GTSVLIMQPI LRFLQLLCEN HNRDLQNFLR CQNNKTNYNL VCETLQFLDI
1910 1920 1930 1940 1950
MCGSTTGGLG LLGLYINEDN VGLVTQTLET LTEYCQGPCH ENQTCIVTHE
1960 1970 1980 1990 2000
SNGIDIITAL ILNDISPLCK YRMDLVLQLK DNASKLLLAL MESRHDSENA
2010 2020 2030 2040 2050
ERILISLRPQ ELVDVIKKAY VQEEEHENSE VSPREVGHNI YILALQLSRH
2060 2070 2080 2090 2100
NKQLQHLLKP VRRIQEEEAE GISSMLSLNN KQLSQMLKPS APALEEEEDP
2110 2120 2130 2140 2150
LAYYENHTSQ IEIVRQDRRM EQIVFPVPAI CQFLTEETKH RLFTTTEQDE
2160 2170 2180 2190 2200
QGSKVSDFFD QSSFLHNEME WQRKLRSMPL IYWFSRRMTL WGSISFNLAV
2210 2220 2230 2240 2250
FINIIIAFFY PYVEGASTGV LGSPLISLLF WILICFSITA LFTKHYSIRP
2260 2270 2280 2290 2300
LIVALILRSI YYLGIGPTLN ILGTLNLTNK IVFVVSFVGN RGTFIRGYKA
2310 2320 2330 2340 2350
MVMDVEFLYH VGYILTSVLG LFAHELFYSI LLFDLVYREE TLFNVIKSVT
2360 2370 2380 2390 2400
RNGRSILLTA LLALILVYLF SIVGFLFLKD DFILQVDRLP GNHSRASPPG
2410 2420 2430 2440 2450
APEGAATFVD TCSGDKMDCV TEVTVPKVLE EDEEPDSTER ACDTLLMCIV
2460 2470 2480 2490 2500
TVMNHGLRNG GGVGDILRRP SKDESLFPAR VVYDLLFYFI VIIIVLNLIF
2510 2520 2530 2540 2550
GVIIDTFADL RSEKQKKEEI LKTTCFICGL ERDKFDNKTV SFEEHIKLEH
2560 2570 2580 2590 2600
NMWSYLHFIV LVRVKNKTDY TGPESYVAQM IKNKNLDWFP RMRAMSLVSS
2610 2620 2630 2640 2650
EGEGEQNEIR ILQDKLSSTM KLVSHLTTQL NELKEQMTEQ RKRRQRLGFV

DVQNCMSR
Length:2,658
Mass (Da):302,038
Last modified:January 20, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0D74D5EF09A86B4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GEBF01005672 Transcribed RNA Translation: JAN97960.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GEBF01005672 Transcribed RNA Translation: JAN97960.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR035910 RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits
PRINTSiPR00779 INSP3RECEPTR
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0P6J5U4_HETGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0P6J5U4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: December 11, 2019
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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