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Entry version 13 (22 Apr 2020)
Sequence version 1 (20 Jan 2016)
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Protein
Submitted name:

Hemocyanin subunit 1

Gene

Tphcy

Organism
Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-bindingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Hemocyanin subunit 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TphcyImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTodarodes pacificus (Japanese flying squid) (Ommastrephes pacificus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6637 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaOegopsinaOmmastrephidaeTodarodes

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0P0UX03

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 77Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini482 – 499Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini627 – 638Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini1039 – 1050Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini1314 – 1331Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini1451 – 1462Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini1729 – 1746Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini1866 – 1877Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini2146 – 2163Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini2291 – 2302Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini2561 – 2578Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini2704 – 2715Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini2980 – 2997Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini3113 – 3124Tyrosinase_Cu-bdInterPro annotationAdd BLAST12

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1280.10, 8 hits
2.60.310.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028999 Haemocyanin_beta-sandwich
IPR036848 Haemocyanin_C_sf
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14830 Haemocyan_bet_s, 8 hits
PF00264 Tyrosinase, 8 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00092 TYROSINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48056 SSF48056, 8 hits
SSF81277 SSF81277, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00497 TYROSINASE_1, 7 hits
PS00498 TYROSINASE_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A0A0P0UX03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NLLRKNVDTL TPDEILNLQV SLRAMQDDEG ASGYQAISAY HGEPADCKAA
60 70 80 90 100
DGSTIVCCLH GMPTFPMWHR LYLVQFEQAL VAHGSTLGIP YWDWTKPMTQ
110 120 130 140 150
LPELVQHPLF IDPTGKKAKK NVFYSGEIKF ENKVTARAVD ARLYQASQEG
160 170 180 190 200
QKNFLLEGVL NALEQEDFCH FEVQLEVAHN PIHYLVGGRF THSMSSLEYT
210 220 230 240 250
SYDPLFFLHH SNVERHFALW QALQKHRGLP TRPNCGLNLF HSPMEPFGRD
260 270 280 290 300
TNPFAITKDN SKASSLFDYE HLGYAFDDLS LNGMTIEELE ALLKQRRSGA
310 320 330 340 350
RAFANFRLGG IKTSANVRIK LCIPTEDKRQ SDNCDNDAGQ FFILGGTNEM
360 370 380 390 400
PWNFAFPYLH EITDTVLSLG LALDSNYYVT AEVTAINGTL MPTQTIPRPI
410 420 430 440 450
VTYIPPQGFK DVNMVNMDTS SLRFRKDISS LTTEEEYELR VAMERFMSDK
460 470 480 490 500
SINGYQALAE FHGLPAKCPR PDALNRVACC IHGMATFPHW HRLVVMQFEN
510 520 530 540 550
ALFTRGSPIG VPYWDWTKPF TALPSLLADE TYVDPYTKET KPNPFFKAPI
560 570 580 590 600
EFLKAGVHTS RQIDERLFKQ PSKGDHGFLY DGLSLAFEQD DFCDFEVQFE
610 620 630 640 650
VTHNSIHAWT GGSEPYSMSS LHYTSFDPMF WLHHSQVDRL WAIWQALQIQ
660 670 680 690 700
RGKPYKTYCA NSEVYRPMKP FAFKSPLNND EKTREHSVPT DVYDYQAELA
710 720 730 740 750
YTYDTLFFGG LSIRELQRYV EEAKSKDRVF AGFLLMGIQT SANVDLFVVA
760 770 780 790 800
GGNEFFVGSI AVLGGSKEMT WRFDRVYKHE ITDALGALGV DMFAEYTLRV
810 820 830 840 850
DIKDVNGTAL PPTAIPPPIV IFVPGIADAN VKFDEQHRSR KNVDSMTVSE
860 870 880 890 900
MNALRTAMAA FAADKEVTGY QQVAAFHGST QWCPSPDAAQ KYACCHHGMA
910 920 930 940 950
TFPHWHRLIA LNFENGLRRN GWSGGLPYWD WTRPIDALPA LVLEAEYTDA
960 970 980 990 1000
NGEAKPNPFF SGAIDSIGAS TSRAPTEALY EKPDFGKYTH LANEIISALE
1010 1020 1030 1040 1050
QEDFCDFEVQ YEIAHNHIHA LVGGTEAVSM ASLEYSAFDP IFMLHHSNVD
1060 1070 1080 1090 1100
RIWATWQALQ KFRGKAYNSA NCAIEILRKP MSPFSLASDI NPDAMTREYS
1110 1120 1130 1140 1150
VPFDVFNYKK NFHYEYDTLE LNGLSIXQLS REINRRKAKN RVXVTFMLEG
1160 1170 1180 1190 1200
LKKSLLVEYF IAADGTDQKM KAGEFYVLGS ENEMPWKFDR PYKSDITYVM
1210 1220 1230 1240 1250
DAMKLHYTDK YHVELRITDM TGAEVTDLKL VTSVIYEPGI GNFGEGRRWI
1260 1270 1280 1290 1300
SPITSASRIR KNLLDFEDGE MESLRNAFKQ MADEGRYEEI ASFHGVPAQC
1310 1320 1330 1340 1350
PSEDGTMVHT CCLHGMPVFP HWHRLYVSLV EDELLARGSG VAVPYWDWVE
1360 1370 1380 1390 1400
PFDELPRLIN EATFYNSRTL QIEPNPFFKG KISFENAETD RDTQPELFGN
1410 1420 1430 1440 1450
RYLYDHTLFV FEQTDFCEFE VHYEVLHNTI HSWLGGRDVH SMSSLDYAAY
1460 1470 1480 1490 1500
DPVFFLHHSN VDRLWAIWQE LQRYRKLSYN EANCALPLMN QPMRPFSNST
1510 1520 1530 1540 1550
ANNDRLTFTN SRPNDVFDYQ NVLHYKYDTL NFAGLSIPQL ERILQKNQGR
1560 1570 1580 1590 1600
DRIFAGFLLH GIKASADVRI YICVPTGIGE ENCGNYAGIF SVLGGETEMP
1610 1620 1630 1640 1650
WQFDRLFRYE ITDELKKLGL NQNSHFRVEM ELTAVNGSKI TQKIFPNPTI
1660 1670 1680 1690 1700
IFVPSDVEFE EDTWRDVVTS ANRIRRNLKD LSKEDMFSLR AAFKRMTDDG
1710 1720 1730 1740 1750
RYEEIAAFHG LPAQCPNADG SNIHTCCLHG MPTFPHWHRL YLSLVENELL
1760 1770 1780 1790 1800
ARGSDVAVPY WDWIEPFDSL PGLISDETYK HPKTNEDIEN PFHHGKISFA
1810 1820 1830 1840 1850
DAVTVRKPRD QLFNNRYLYE HALFAFEHTD FCDFEVHFEV LHNSIHSWIG
1860 1870 1880 1890 1900
GPNPHSMSSL DFAAYDPIFF LHHSTVDRLW AIWQDLQRYR KLDYNVANCA
1910 1920 1930 1940 1950
LNLLNDPMRP FNNKTANQDH LTFTNSRPND VFDYQNSLNY KFDSLSFSGL
1960 1970 1980 1990 2000
SIPRLDDLLE SRQSHDRVFA GFWLSGIKAS ADVNIHICVP IGVEHEDCDN
2010 2020 2030 2040 2050
YAGTFAVLGG ETEMPWAFDR LFRYEISDEM KKLQLTEDSK FRLTTNIIAS
2060 2070 2080 2090 2100
NGSKVSNDIF PTPTVIFVPK KERTEQVSTT KSVRGNLVRK NVDRLSLQEI
2110 2120 2130 2140 2150
NSLIHALKRM QKDRSSDGFE TIASFHALPP LCPNPTAKHR HACCLHGMAT
2160 2170 2180 2190 2200
FPQWHRLYVV QFEHSLNRHG AIVGVPYWDW TYPMTEVPGL LTSEKYTDPF
2210 2220 2230 2240 2250
TGIETFNPFN HGHISFISPE TMTTREVSEH LFEQPALGKQ TWLFNNIILA
2260 2270 2280 2290 2300
LEQTDYCDFE VQFEIVHNSI HSWLGGKELY SLNHLHYAAY DPAFFLHHSN
2310 2320 2330 2340 2350
VDRLWVVWQE LQKFRGLPAY ESNCAIELMS QPLKPFSFGA PYNLNPVTTK
2360 2370 2380 2390 2400
YSKPSDVFNY KQNFHYEYDM LEMNGMSIAQ LESYIRQERQ KDRVFAGFLL
2410 2420 2430 2440 2450
EGFGSSAYAT FQVCPDVGDC YEGSHFSVLG GSTEMPWAFD RLYKMEITDI
2460 2470 2480 2490 2500
LQAMDLKFDS HFTIKTKIVA HNGTELPESL LPEATIVRIP PSAQNLEVAI
2510 2520 2530 2540 2550
PLNRIRRNIN SLESRDVQNL MSALKRLKED ESDFGFQTIA GYHGSLMCPT
2560 2570 2580 2590 2600
PEAPEYACCL HGMPTFMHWH RVYLLHFEES MRRHGASVAV PYWDWTMPSD
2610 2620 2630 2640 2650
NLPSLLGDAD YYDAWTDSVI ENPFLRGHIK YEDTYTVREI QPELFALAEG
2660 2670 2680 2690 2700
QKESTLFKDV MLMFEQEDYC DFEVQAEVIH NSIHYLIGGH QKYAMSSLMF
2710 2720 2730 2740 2750
SSFDPIFYVH HSMVDRLWAI WQELQKHRKL PHDKAYCALD QMAFPMKPFI
2760 2770 2780 2790 2800
WESNPNPTTR AVSTPSKLFD YKSLGYDYDH LNFHGMSIGQ LEALIQKQKK
2810 2820 2830 2840 2850
ADRVFAGFLL HGIKISADVH LKICIEADCQ EAGVIFVLGG ETEMPWHFDR
2860 2870 2880 2890 2900
NYKMDITDVL KKRNIPPEAL FEHDSKIRLE VEIKSVDGAV LDPNSLPKPS
2910 2920 2930 2940 2950
LIYAPAKGLI IQQVGEYDAG SMVRKNVNSL TPSEIENLRN ALAAVQADKT
2960 2970 2980 2990 3000
DAGYQKIASF HGMPLSCQYP DGTAFACCQH GMVTFPHWHR LYMKQMEDAL
3010 3020 3030 3040 3050
KAKGAKIGIP YWDWTTAFHS LPILVTEPKN NPFHHGYIDV ADTKTTRDPR
3060 3070 3080 3090 3100
PQLFDDPEQG DQSFFYRQIA FALEQRDFCD FEIQFEMGHN AIHSWVGGPS
3110 3120 3130 3140 3150
PYGMSTLHYT SYDPLFYVHH SNTDRIWAIW QALQKYRGLP YNSANCEINK
3160 3170 3180 3190 3200
LKKPMMPFSS EDNPNEVTKA HSTGYKSFDY QQLNYEYDNL NFHGMTIPQL
3210 3220 3230 3240 3250
EVHLKKIQEK DRVFAGFLLR AIGQSADVNF DVCRKDGECT FGGTFCVLGG
3260 3270 3280 3290 3300
DYEMPWAFDR LFLYDISKSL VHLRLDAHDD FDIKVTIMGI DGKSLPPNLL
3310
PSPTILFKPG TGKI
Length:3,314
Mass (Da):379,348
Last modified:January 20, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i209A4423553324A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
<p>This subsection of the 'Sequences' section is used to describe region(s) of a sequence for which the authors are unsure about the sequence assignment.<p><a href='/help/unsure' target='_top'>More...</a></p>Sequence uncertaintyi2455D or NImported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB897790 Genomic DNA Translation: BAS69907.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB897790 Genomic DNA Translation: BAS69907.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6R83electron microscopy5.1010a/1a/2a/3a/4a/5a/6a/7a/8a/9a1-3314[»]
SMRiA0A0P0UX03
ModBaseiSearch...
PDBe-KBiSearch...

Family and domain databases

Gene3Di1.10.1280.10, 8 hits
2.60.310.10, 8 hits
InterProiView protein in InterPro
IPR028999 Haemocyanin_beta-sandwich
IPR036848 Haemocyanin_C_sf
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF14830 Haemocyan_bet_s, 8 hits
PF00264 Tyrosinase, 8 hits
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 8 hits
SSF81277 SSF81277, 8 hits
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 7 hits
PS00498 TYROSINASE_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0P0UX03_TODPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0P0UX03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: April 22, 2020
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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