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Protein

Malate dehydrogenase

Gene

mdh_1

Organism
Bacteroides thetaiotaomicron
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdh_1Imported
Synonyms:mdhUniRule annotationImported, mdh_2Imported
ORF Names:BJP75_007910Imported, BSIG_2758Imported, Btheta7330_00504Imported, ERS852430_02157Imported, ERS852461_05137Imported, ERS852511_01079Imported, ERS852557_00080Imported, HMPREF2534_01334Imported, SAMN02910322_00946Imported
OrganismiBacteroides thetaiotaomicronImported
Taxonomic identifieri818 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000095686 Componenti: Unassembled WGS sequence
  • UP000095606 Componenti: Unassembled WGS sequence
  • UP000070364 Componenti: Unassembled WGS sequence
  • UP000178402 Componenti: Unassembled WGS sequence
  • UP000095541 Componenti: Unassembled WGS sequence
  • UP000181882 Componenti: Unassembled WGS sequence
  • UP000095576 Componenti: Unassembled WGS sequence
  • UP000066931 Componenti: Chromosome
  • UP000003591 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

SMRiA0A0P0FIP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 143Ldh_1_NInterPro annotationAdd BLAST141
Domaini148 – 300Ldh_1_CInterPro annotationAdd BLAST153

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

KOiK00024
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0P0FIP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVTVVGAG NVGATCANVL AFNEVADEVV MLDVKEGVSE GKAMDMMQTA
60 70 80 90 100
QLLGFDTTVV GCTNDYAQTA NSDVVVITSG IPRKPGMTRE ELIGVNAGIV
110 120 130 140 150
KSVAENILKY SPNAILVVIS NPMDTMTYLS LKALGLPKNR IIGMGGALDS
160 170 180 190 200
SRFKYFLSQA LGCNANEVEG MVIGGHGDTT MIPLTRFATY KGMPVTNFIS
210 220 230 240 250
EEKLNEVAAA TMVGGATLTK LLGTSAWYAP GAAGAFVVES ILHDQKKMIP
260 270 280 290 300
CSVYLEGEYG ESDICIGVPV ILGKNGIEKI VELDLNADEK AKFAASAKAV
310
HGTNAALKEV GAL
Length:313
Mass (Da):32,763
Last modified:January 20, 2016 - v1
Checksum:i04DAA0866E41624C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP012937 Genomic DNA Translation: ALJ40088.1
CYYB01000005 Genomic DNA Translation: CUN04720.1
CZAP01000002 Genomic DNA Translation: CUP07537.1
CZBI01000001 Genomic DNA Translation: CUP27965.1
CZAE01000054 Genomic DNA Translation: CUQ35654.1
ACIC02000005 Genomic DNA Translation: EES68797.1
LTDD01000040 Genomic DNA Translation: KXT41418.1
MKXM02000026 Genomic DNA Translation: PLS61171.1
FOAL01000002 Genomic DNA Translation: SEK67997.1
RefSeqiWP_008760830.1, NZ_PUEO01000014.1

Genome annotation databases

EnsemblBacteriaiALJ40088; ALJ40088; Btheta7330_00504
EES68797; EES68797; BSIG_2758
KXT41418; KXT41418; HMPREF2534_01334
GeneIDi31615053
KEGGibtho:Btheta7330_00504
PATRICifig|818.23.peg.509

Similar proteinsi

Entry informationi

Entry nameiA0A0P0FIP7_BACT4
AccessioniPrimary (citable) accession number: A0A0P0FIP7
Secondary accession number(s): C6ILY7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: July 18, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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